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Heplisav-B (Intramuscular)

Generic Name: hepatitis b vaccine recombinant, adjuvanted (Intramuscular route)

hep-a-TYE-tis B VAX-een ree-KOM-bi-nant, AD-joo-van-ted

Medically reviewed on Oct 31, 2018

Commonly used brand name(s)

In the U.S.

  • Heplisav-B

Available Dosage Forms:

  • Solution

Therapeutic Class: Vaccine

Uses For Heplisav-B

Hepatitis B vaccine is used to prevent infection caused by all known subtypes of the hepatitis B virus.

This vaccine is to be given by or under the direct supervision of your doctor.

Before Using Heplisav-B

In deciding to use a vaccine, the risks of taking the vaccine must be weighed against the good it will do. This is a decision you and your doctor will make. For this vaccine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of hepatitis B vaccine in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hepatitis B vaccine in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this vaccine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to yeast—Should not be used in patients with this condition.
  • Hepatitis B infection, active or unrecognized or
  • Weak immune system—May decrease the effect of the vaccine and the body's response to it.

Proper Use of Heplisav-B

A nurse or other trained health professional will give you this medicine. It is given as a shot into one of your muscles, usually in the deltoid (upper arm).

This medicine is given as two doses, one month apart. To get the best possible protection against infection with the HBV virus, you should complete your vaccine dosing schedule.

Precautions While Using Heplisav-B

It is important that your doctor check your progress to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results..

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Heplisav-B Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

  • Chest pain or discomfort
  • inability to move the arms and legs
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • sudden numbness and weakness in the arms and legs
  • sweating
  • vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • General feeling of discomfort or illness
  • headache
  • pain at the injection site
  • unusual tiredness or weakness

Less common

  • Fever
  • redness or swelling at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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