Enbumyst

Pronunciation: En-byoo-mist
Generic name: bumetanide nasal spray
Dosage form: nasal spray (0.5 mg bumetanide per 0.1 mL spray)
Drug class: Loop diuretics

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 16, 2025.

What is Enbumyst? Bumetanide Nasal Spray for Edema

Enbumyst is a loop diuretic nasal spray used in adults for the short-term treatment of edema (fluid retention) associated with congestive heart failure, liver disease, and kidney disease, including nephrotic syndrome. Enbumyst is a single-use nasal spray administered once daily.

Key Treatment Details:

• Generic name: Bumetanide nasal spray
• Brand name: Enbumyst
• Treatment type: Loop diuretic nasal spray
• Administration: Once daily
• FDA approval date: September 14, 2025

How Does Enbumyst Work? Mechanism of Action

Enbumyst contains bumetanide, a potent loop diuretic that works by:

• Inhibiting sodium and chloride reabsorption in the kidney tubules
• Targeting the proximal tubules, distal tubules, and loop of Henle
• Providing a rapid diuretic effect through its unique site of action
• Working independently of carbonic anhydrase and aldosterone inhibition.

Enbumyst Side Effects

Common Side Effects

• Dehydration (low body fluid levels)
• Headache
• Muscle cramps
• Dizziness
• Hypotension (low blood pressure)
• Nausea
• Hepatic encephalopathy (in patients with liver problems).

Serious Side Effects and Warnings

Fluid and Electrolyte Imbalances

Enbumyst is a diuretic that causes fluid loss and may lead to abnormalities with blood electrolytes and body energy systems (metabolic). Too much fluid loss can lead to dehydration and decreased blood volume, and increase your risk of blood clots.

Blood abnormalities may include:

• decreased salts (electrolytes)
• increased nitrogen, glucose, and uric acid.

The likelihood of developing these abnormalities is higher in individuals who are elderly, use higher doses, or do not receive sufficient electrolytes orally.

Your healthcare provider should do blood tests to check for these abnormalities during treatment with Enbumyst. Do not use Enbumyst if you have severe electrolyte loss until it gets better.

Warning Signs to Report Immediately: 

• Unusual thirst
• Dizziness or lightheadedness
• Weakness or tiredness
• Fast heart rate
• Dry mouth or tongue
• Sudden pain, redness, or swelling in your joints, especially your big toe (gout)
• Leg pain, swelling, or warmth (blood clot signs)
• Shortness of breath
• High blood sugar symptoms
• Dark urine
• Muscle cramps
• Confusion.

Other Serious Risks

• Kidney function deterioration
• Ototoxicity (ear damage, hearing loss, tinnitus)
• Higher risk in elderly patients and those on higher doses.

It is not known if Enbumyst is safe and effective in children.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Enbumyst. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Related/similar drugs

Who should not use Enbumyst?

Absolute Contraindications

• Anuria (no urine production) or severe oliguria (very little urine production)
• Known allergy to bumetanide or Enbumyst ingredients.

Before Using

Inform your healthcare provider if you have:

• Electrolyte imbalances or eat a low-salt diet
• Diabetes mellitus
• Chronic diarrhea
• Nasal conditions: polyps, previous nasal surgery, broken nose, congestion
• Pregnancy or breastfeeding plans.

Pregnancy and Breastfeeding Considerations

Pregnancy: It is not known if Enbumyst will harm your unborn baby.

Breastfeeding: It is not known if Enbumyst passes into your breastmilk. If you use Enbumyst and breastfeed, watch your baby for signs of urinating more than usual, dehydration, or unusual sleepiness, drowsiness, or sluggishness.

How do I use Enbumyst?

Read the Instructions for Use that come with Enbumyst for detailed information about how to use the device.

Use Enbumy exactly as your healthcare provider tells you to. Talk to your healthcare provider or pharmacist if you have questions about how to use this medicine.

• Enbumyst is for use in the nose only.
• Each Enbumyst device has 1 spray of medicine and cannot be reused.

Device Usage Chart

Use the following number of nasal spray devices for your prescribed dose:

Important Administration Guidelines

• Single-use devices only - cannot be reused
• No priming or testing required
• Available in 6-device or 12-device cartons
• Short-term use only for single treatment episodes
• Switch to oral diuretics as soon as practical.

Dosing information

• Enbumyst is for the nasal route only.
• Your doctor will individualize your dosage based on your response.

Recommended Enbumyst Dose for Edema (Adult)

• 0.5 mg to 2 mg administered once daily.

Enbumyst is not intended for chronic use; replace with oral diuretics as soon as practical.

What other drugs will affect Enbumyst?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Enbumyst and other medicines may affect each other, causing side effects, and may affect the way each other work. Especially tell your healthcare provider if you take or use:

• Other nasal sprays
• Water pills (diuretics)
• Lithium
• Probenecid
• Indomethacin
• Antibiotic medicines called aminoglycosides
• Medicines to treat high blood pressure.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I store Enbumyst?

• Store Enbumystat at room temperature between 59°F to 77°F (15°C to 25°C).
• Do not freeze.

Keep out of the reach of children.

What are the ingredients in Enbumyst?

Active Ingredient: bumetanide

Inactive Ingredients: benzyl alcohol (0.5 mg per 0.1 mL spray, carboxymethyl cellulose sodium, benzyl alcohol, mannitol, potassium hydroxide (pH modifier), hydrochloric acid (to adjust pH), and water for injection.

Manufacturer

Enbumyst is manufactured for Corstasis Therapeutics, 3535 Executive Terminal Drive, Henderson, NV 89042.

Frequently asked questions

• What are the equivalent dosages of bumetanide, furosemide & torsemide?

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer