Sulfamethoxazole/trimethoprim Drug Interactions
Currently displaying a list of 455 drugs known to interact with sulfamethoxazole / trimethoprim.
- 63 major drug interactions
- 180 moderate drug interactions
- 212 minor drug interactions
Medications known to interact with sulfamethoxazole/trimethoprim
Note: Showing generic names only.
A
- abarelix
- abiraterone
- acetohexamide
- adagrasib
- albuterol
- alfuzosin
- alpelisib
- amantadine
- amiloride
- aminolevulinic acid
- aminolevulinic acid topical
- amiodarone
- amisulpride
- amitriptyline
- amoxapine
- anagrelide
- anisindione
- apalutamide
- apomorphine
- aripiprazole
- arsenic trioxide
- asciminib
- asenapine
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- astemizole
- atezolizumab
- atomoxetine
- atovaquone
- avelumab
- azathioprine
- azilsartan medoxomil
- azithromycin
B
- bacitracin
- balsalazide
- bcg
- bedaquiline
- benazepril
- benoxinate ophthalmic
- benzgalantamine
- benzocaine topical
- bepridil
- bicalutamide
- bifidobacterium infantis
- bifidobacterium longum
- binimetinib
- black cohosh
- bosutinib
- brentuximab
- bupivacaine
- bupivacaine liposome
- buprenorphine
C
- cabozantinib
- calaspargase pegol
- candesartan
- cannabidiol
- capreomycin
- captopril
- carbamazepine
- carvedilol
- ceftazidime
- celecoxib
- cemiplimab
- ceritinib
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chloroprocaine
- chloroprocaine ophthalmic
- chloroquine
- chlorpromazine
- chlorpropamide
- cholera vaccine, live
- cilostazol
- ciprofloxacin
- cisapride
- citalopram
- clarithromycin
- clofarabine
- clofazimine
- clomipramine
- clozapine
- cocaine nasal
- cocaine topical
- colistimethate
- conjugated estrogens
- cosibelimab
- creatine
- crizotinib
- cyclosporine
D
- dabrafenib
- daclizumab
- dalfampridine
- daprodustat
- dapsone
- dapsone topical
- dasatinib
- daunorubicin
- daunorubicin liposomal
- degarelix
- desipramine
- deutetrabenazine
- dibucaine topical
- dicumarol
- diethylstilbestrol
- digoxin
- dimethyl fumarate
- diroximel fumarate
- disopyramide
- dofetilide
- dolasetron
- dostarlimab
- doxepin
- doxepin topical
- doxorubicin
- doxorubicin liposomal
- dronedarone
- droperidol
- drospirenone
- durvalumab
E
- efavirenz
- enalapril
- enalaprilat
- encorafenib
- ensifentrine
- entrectinib
- enzalutamide
- epirubicin
- eplerenone
- eprosartan
- eribulin
- erythromycin
- escitalopram
- estradiol
- estropipate
- ethanol
- ethinyl estradiol
- ethotoin
- etidocaine
- etranacogene dezaparvovec
- etrasimod
- etravirine
- ezogabine
F
- famotidine
- fecal microbiota spores, live
- fecal microbiota, live
- fenofibrate
- fexinidazole
- fidanacogene elaparvovec
- finerenone
- fingolimod
- flecainide
- fluconazole
- fluoxetine
- fluphenazine
- flutamide
- folic acid
- foscarnet
- fosinopril
- fosphenytoin
- fostemsavir
G
- galantamine
- ganciclovir
- gatifloxacin
- gemifloxacin
- gepirone
- gilteritinib
- givinostat
- givosiran
- glasdegib
- glimepiride
- glipizide
- glucarpidase
- glyburide
- goserelin
- granisetron
- grepafloxacin
H
I
- ibutilide
- idarubicin
- idelalisib
- iloperidone
- imipramine
- indinavir
- indium oxyquinoline in-111
- inotuzumab ozogamicin
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- interferon beta-1a
- interferon beta-1b
- ipilimumab
- irbesartan
- isoniazid
- ivacaftor
- ivosidenib
K
L
- lactobacillus acidophilus
- lactobacillus reuteri
- lactobacillus rhamnosus
- lactobacillus rhamnosus gg
- lamivudine
- lamotrigine
- lapatinib
- lefamulin
- lenvatinib
- lesinurad
- leucovorin
- leuprolide
- levobupivacaine
- levofloxacin
- levoketoconazole
- levoleucovorin
- levomethadyl acetate
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- lisdexamfetamine
- lisinopril
- lithium
- lofexidine
- lomefloxacin
- lomitapide
- lonafarnib
- lorlatinib
- losartan
- lusutrombopag
- lvp solution with potassium
M
- macimorelin
- maprotiline
- mavacamten
- mavorixafor
- mefloquine
- meloxicam
- memantine
- mephenytoin
- mepivacaine
- mercaptopurine
- mesoridazine
- metformin
- methadone
- methenamine
- methotrexate
- methotrimeprazine
- methoxsalen
- methyl aminolevulinate topical
- metronidazole
- midostaurin
- mifepristone
- mipomersen
- mirtazapine
- mobocertinib
- moexipril
- monomethyl fumarate
- montelukast
- moxifloxacin
- mycophenolate mofetil
- mycophenolic acid
N
- naltrexone
- nateglinide
- nilotinib
- nilutamide
- niraparib
- nitisinone
- nivolumab
- norfloxacin
- nortriptyline
O
- ofloxacin
- olanzapine
- oliceridine
- olmesartan
- olodaterol
- ondansetron
- oritavancin
- osilodrostat
- osimertinib
- oxaliplatin
- oxytocin
- ozanimod
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- paliperidone
- palonosetron
- panobinostat
- papaverine
- parenteral nutrition solution w/electrolytes
- pasireotide
- pazopanib
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- pentamidine
- perflutren
- perindopril
- perphenazine
- pexidartinib
- phenobarbital
- phenytoin
- pimavanserin
- pimozide
- pindolol
- pioglitazone
- pitolisant
- plazomicin
- polymyxin b
- ponesimod
- porfimer
- posaconazole
- potassium acetate
- potassium acid phosphate
- potassium aminobenzoate
- potassium bicarbonate
- potassium chloride
- potassium citrate
- potassium gluconate
- potassium iodide
- potassium perchlorate
- potassium phosphate
- pralatrexate
- pralsetinib
- pramoxine topical
- prilocaine
- primaquine
- primidone
- probucol
- procainamide
- procaine
- procaine penicillin
- prochlorperazine
- promazine
- promethazine
- propafenone
- proparacaine ophthalmic
- propofol
- propoxyphene
- protriptyline
- pyrimethamine
Q
R
- ramipril
- ranolazine
- relugolix
- remdesivir
- repaglinide
- retifanlimab
- revumenib
- ribociclib
- rifampin
- rifapentine
- rilpivirine
- risperidone
- ritonavir
- romidepsin
- ropivacaine
- rosiglitazone
- rucaparib
S
- sapropterin
- saquinavir
- selexipag
- selpercatinib
- sertraline
- sevoflurane
- siponimod
- sodium iodide i-123
- sodium iodide-i-131
- sodium nitrite
- solifenacin
- sorafenib
- sotalol
- sparfloxacin
- sparsentan
- spironolactone
- st. john's wort
- sunitinib
T
- tacrolimus
- tamoxifen
- tebentafusp
- telavancin
- telithromycin
- telmisartan
- terbutaline
- terfenadine
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thioguanine
- thiopental
- thioridazine
- tislelizumab
- tizanidine
- tolazamide
- tolbutamide
- tolvaptan
- toremifene
- toripalimab
- torsemide
- tovorafenib
- trabectedin
- tramadol
- trandolapril
- trazodone
- tremelimumab
- treprostinil
- triamterene
- triclabendazole
- trifluoperazine
- triflupromazine
- trimeprazine
- trimipramine
- triptorelin
- tucatinib
- typhoid vaccine, live
V
- vadadustat
- valbenazine
- valdecoxib
- valganciclovir
- valoctocogene roxaparvovec
- valsartan
- vancomycin
- vandetanib
- vardenafil
- vasopressin
- vemurafenib
- venlafaxine
- verteporfin
- voclosporin
- voriconazole
W
Z
Sulfamethoxazole/trimethoprim alcohol/food interactions
There is 1 alcohol/food interaction with sulfamethoxazole / trimethoprim.
Sulfamethoxazole/trimethoprim disease interactions
There are 12 disease interactions with sulfamethoxazole / trimethoprim which include:
- colitis
- hematologic toxicity
- hypersensitivity reactions
- liver disease
- porphyria
- renal dysfunction
- folate deficiency
- crystalluria
- hemodialysis
- urinary obstruction
- dialysis
- renal dysfunction
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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