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Co-trimoxazole (sulfamethoxazole / trimethoprim) Drug Interactions

A total of 505 drugs are known to interact with Co-trimoxazole (sulfamethoxazole / trimethoprim).

  • 112 major drug interactions
  • 167 moderate drug interactions
  • 226 minor drug interactions

Show all medications in the database that may interact with Co-trimoxazole (sulfamethoxazole / trimethoprim).

Check for interactions

Type in a drug name to check for interactions with Co-trimoxazole (sulfamethoxazole / trimethoprim).

Most frequently checked interactions

View interaction reports for Co-trimoxazole (sulfamethoxazole / trimethoprim) and the medicines listed below.

  • acyclovir (Zovirax, Sitavig)
  • amlodipine (Norvasc)
  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Amoxicot, Moxatag, DisperMox, Moxilin, Wymox, Biomox)
  • aspirin (Aspir 81, Ecotrin, Aspirin Low Strength, Acetylsalicylic Acid, Bayer Aspirin, Aspir-Low, Bufferin, Ascriptin, Arthritis Pain, Aspiritab, Aspergum, Fasprin, Halfprin, Easprin, Ecotrin Adult Low Strength, Empirin, Migralex, Aspi-Cor, St. Joseph 81 mg Chewable Aspirin, Bayer Children's Aspirin, Buffered Aspirin, Durlaza, Ecotrin Maximum Strength, Entercote, Bufferin Extra Strength, Ascriptin Enteric, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspirtab, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • bisoprolol (Zebeta)
  • ciprofloxacin (Cipro, Cipro XR, Cipro I.V., Cipro Cystitis Pack, Proquin XR)
  • clarithromycin (Biaxin, Biaxin XL)
  • fluconazole (Diflucan)
  • folic acid (Folvite, FA-8, Folacin-800, FaLessa)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • methotrexate (Rasuvo, Methotrexate LPF Sodium, Trexall, Otrexup, Rheumatrex Dose Pack, Xatmep, Folex PFS)
  • metronidazole (Flagyl, Flagyl IV, Metro, Flagyl ER, Flagyl 375, Metro IV, Protostat, Metryl)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • ondansetron (Zofran, Zofran ODT, Zuplenz)
  • Paracetamol (acetaminophen)
  • prednisolone (Prelone, Orapred, Millipred, Flo-Pred, Veripred 20, AsmalPred Plus, Delta-Cortef, Orapred ODT, Hydeltra-TBA, Hydeltrasol, Key-Pred, Cotolone, Predicort-50, Predalone 50, Predacort 50, Predate-50, Predaject-50, PediaPred, Pred-Ject-50, Key-Pred SP, Medicort, Predicort RP, Pri-Cortin 50, Predcor, Bubbli-Pred, Millipred DP)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • ranitidine (Zantac, Zantac 150, Zantac 75, Zantac 300, Acid Reducer, Zantac 150 EFFERdose, Taladine, Zantac 25 mg EFFERdose, Berkley and Jensen Acid Reducer Maximum Strength, Deprizine, Zantac GELdose, Zantac 300 GELdose, Zantac EFFERdose, Acid Reducer Non-Prescription Strength, Zantac Injection, Acid Relief, Sunmark Acid Reducer Maximum Strength, Acid Control 75, Careone Acid Reducer, Equaline Heartburn Relief, Acid Control 150)
  • sulfamethoxazole / trimethoprim (Bactrim, Bactrim DS, Septra, SMZ-TMP DS, Septra DS, Co-trimoxazole, Sulfatrim, Cotrim, Sulfatrim Pediatric, Bactrim Pediatric, Bactrim IV, Cotrim DS, Bethaprim, Uroplus, Uroplus DS, Septra IV, Bethaprim Pediatric, Cotrim Pediatric)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, ConZip, Zydol, Tramal SR, GenRx Tramadol, Zamadol, Ryzolt, Tramedo, Larapam SR, Tramahexal SR, Tramahexal, Zydol XL, Rybix ODT, Ultram ODT)
  • valganciclovir (Valcyte)

Co-trimoxazole (sulfamethoxazole / trimethoprim) alcohol/food interactions

There is 1 alcohol/food interaction with Co-trimoxazole (sulfamethoxazole / trimethoprim)

Co-trimoxazole (sulfamethoxazole / trimethoprim) disease interactions

There are 12 disease interactions with Co-trimoxazole (sulfamethoxazole / trimethoprim) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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