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Co-trimoxazole (sulfamethoxazole / trimethoprim) Drug Interactions

A total of 495 drugs are known to interact with Co-trimoxazole (sulfamethoxazole / trimethoprim).

  • 112 major drug interactions
  • 165 moderate drug interactions
  • 218 minor drug interactions

Show all medications in the database that may interact with Co-trimoxazole (sulfamethoxazole / trimethoprim).

Check for interactions with Co-trimoxazole (sulfamethoxazole / trimethoprim)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Co-trimoxazole (sulfamethoxazole / trimethoprim)

  • acyclovir (Zovirax, Sitavig)
  • amlodipine (Norvasc)
  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Moxatag, Moxilin, Amoxicot, DisperMox, Wymox, Biomox)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Arthritis Pain, Fasprin, Ecotrin Adult Low Strength, Low Dose ASA, Bufferin, Aspiritab, Aspirin Lite Coat, Easprin, Bayer Children's Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Aspirtab, Halfprin, Aspergum, Durlaza, Acuprin 81, Miniprin, Bufferin Low Dose, Empirin, Buffered Aspirin, Entercote, St. Joseph Aspirin, Ascriptin Enteric, Ecpirin, Bayer Women's Aspirin With Calcium, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspi-Cor, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Bayer Aspirin Extra Strength Plus, Buffex, Ecotrin Maximum Strength, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, Zero-Order Release, YSP Aspirin, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • bisoprolol (Zebeta)
  • ciprofloxacin (Cipro, Cipro Cystitis Pack, Cipro XR, Cipro I.V., Proquin XR)
  • clarithromycin (Biaxin, Biaxin XL)
  • fluconazole (Diflucan)
  • folic acid (Folvite, FaLessa, Folacin-800, FA-8)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Advil Infant's Concentrated Drops, Children's Motrin, Advil Children's, Ibu-8, Ibuprofen PMR, Caldolor, Motrin Childrens, Motrin Migraine Pain, Addaprin, Ibu-4, Ibu-Tab, Rufen, Midol IB, A-G Profen, Childrens Ibuprofen Berry, Advil Migraine, Ibu-6, Motrin Infant Drops, NeoProfen, Genpril, Haltran, Menadol, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • methotrexate (Trexall, Otrexup, Rasuvo, Methotrexate LPF Sodium, Xatmep, Rheumatrex Dose Pack, Folex PFS)
  • metronidazole (Flagyl, Flagyl IV, Metro, Metro IV, Flagyl 375, Flagyl ER, Protostat, Metryl)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • ondansetron (Zofran, Zofran ODT, Zuplenz)
  • Paracetamol (acetaminophen)
  • prednisolone (Prelone, Orapred, Millipred, Orapred ODT, AsmalPred Plus, Predalone 50, PediaPred, Veripred 20, Predicort RP, Millipred DP, Delta-Cortef, Flo-Pred, Hydeltra-TBA, Hydeltrasol, Key-Pred, Cotolone, Predicort-50, Predacort 50, Predate-50, Predaject-50, Pred-Ject-50, Key-Pred SP, Medicort, Pri-Cortin 50, Predcor, Bubbli-Pred)
  • prednisone (Deltasone, Rayos, Sterapred DS, Sterapred, Prednicot, Meticorten, Liquid Pred, Orasone, Prednicen-M)
  • ranitidine (Zantac, Zantac 150, Zantac 75, Zantac 300, Deprizine, Acid Reducer, Zantac Injection, Zantac 25 mg EFFERdose, Berkley and Jensen Acid Reducer Maximum Strength, Zantac GELdose, Zantac 300 GELdose, Zantac EFFERdose, Acid Reducer Non-Prescription Strength, Acid Relief, Sunmark Acid Reducer Maximum Strength, Zantac 150 EFFERdose, Acid Control 75, Taladine, Careone Acid Reducer, Equaline Heartburn Relief, Acid Control 150)
  • sulfamethoxazole / trimethoprim (Bactrim, Bactrim DS, Septra, Septra DS, SMZ-TMP DS, Sulfatrim, Co-trimoxazole, Bactrim Pediatric, Sulfatrim Pediatric, Cotrim, Bactrim IV, Bethaprim, Uroplus, Uroplus DS, Cotrim DS, Septra IV, Bethaprim Pediatric, Cotrim Pediatric)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramedo, GenRx Tramadol, ConZip, Zydol, Ryzolt, Larapam SR, Tramahexal, Zamadol, Tramal SR, Tramahexal SR, Zydol XL, Rybix ODT, Rybix, Ultram ODT)
  • valganciclovir (Valcyte)

Co-trimoxazole (sulfamethoxazole / trimethoprim) alcohol/food Interactions

There is 1 alcohol/food interaction with Co-trimoxazole (sulfamethoxazole / trimethoprim)

Co-trimoxazole (sulfamethoxazole / trimethoprim) disease Interactions

There are 12 disease interactions with Co-trimoxazole (sulfamethoxazole / trimethoprim) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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