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Co-trimoxazole (sulfamethoxazole / trimethoprim) Drug Interactions

A total of 512 drugs are known to interact with Co-trimoxazole (sulfamethoxazole / trimethoprim).

  • 114 major drug interactions
  • 169 moderate drug interactions
  • 229 minor drug interactions

Show all medications in the database that may interact with Co-trimoxazole (sulfamethoxazole / trimethoprim).

Check for interactions

Type in a drug name to check for interactions with Co-trimoxazole (sulfamethoxazole / trimethoprim).

Most frequently checked interactions

View interaction reports for Co-trimoxazole (sulfamethoxazole / trimethoprim) and the medicines listed below.

  • acyclovir (Zovirax, Sitavig)
  • amlodipine (Norvasc)
  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Moxatag, Amoxicot, DisperMox, Biomox, Moxilin, Wymox)
  • aspirin (Ecotrin, Acetylsalicylic Acid, Aspir 81, Bayer Aspirin, Aspirin Low Strength, Bufferin, Arthritis Pain, Easprin, Ascriptin, Fasprin, Low Dose ASA, Buffered Aspirin, Aspir-Low, Durlaza, Ascriptin Enteric, Acuprin 81, Halfprin, Aspergum, Empirin, Bayer Children's Aspirin, Aspirin Lite Coat, Aspi-Cor, Aspirtab, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Entercote, Minitabs, St. Joseph Aspirin, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Aspiritab, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Bayer Aspirin Regimen, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • bisoprolol (Zebeta)
  • ciprofloxacin (Cipro, Cipro I.V., Cipro XR, Cipro Cystitis Pack, Proquin XR)
  • clarithromycin (Biaxin, Biaxin XL)
  • doxycycline (Vibramycin, Monodox, Oracea, Doxy 100, Doryx, Adoxa, Acticlate, Targadox, Morgidox, Vibra-Tabs, Doxy-Caps, Uracil, Periostat, Avidoxy, Adoxa TT, Mondoxyne NL, Doxy 200, Doxy-D, Oraxyl, Alodox, Adoxa Pak, Adoxa CK, Ocudox, LymePak, NicAzel Doxy, Doxy-Lemmon, Doryx MPC)
  • fluconazole (Diflucan)
  • folic acid (Folvite, Folacin-800, FA-8, FaLessa)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • methotrexate (Otrexup, Trexall, Rasuvo, Methotrexate LPF Sodium, Xatmep, Rheumatrex Dose Pack, Folex PFS)
  • metronidazole (Flagyl, Flagyl IV, Metro, Flagyl ER, Flagyl 375, Protostat, Metryl, Metro IV)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • ondansetron (Zofran, Zofran ODT, Zuplenz)
  • Paracetamol (acetaminophen)
  • prednisolone (Orapred, Prelone, PediaPred, Predicort RP, Veripred 20, Millipred, Orapred ODT, Flo-Pred, Predaject-50, Medicort, Predcor, Millipred DP, AsmalPred Plus, Delta-Cortef, Hydeltra-TBA, Hydeltrasol, Key-Pred, Cotolone, Predicort-50, Predalone 50, Predacort 50, Predate-50, Pred-Ject-50, Key-Pred SP, Pri-Cortin 50, Bubbli-Pred)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Sterapred DS, Liquid Pred, Meticorten, Orasone, Prednicen-M)
  • ranitidine (Zantac, Zantac 150, Zantac 300, Zantac 75, Acid Reducer, Deprizine, Acid Relief, Zantac 25 mg EFFERdose, Berkley and Jensen Acid Reducer Maximum Strength, Zantac GELdose, Zantac 300 GELdose, Zantac EFFERdose, Acid Reducer Non-Prescription Strength, Zantac Injection, Sunmark Acid Reducer Maximum Strength, Zantac 150 EFFERdose, Acid Control 75, Taladine, Careone Acid Reducer, Equaline Heartburn Relief, Acid Control 150)
  • sulfamethoxazole / trimethoprim (Bactrim, Bactrim DS, Septra, SMZ-TMP DS, Co-trimoxazole, Septra DS, Cotrim, Bactrim Pediatric, Sulfatrim Pediatric, Sulfatrim, Bactrim IV, Cotrim DS, Uroplus, Septra IV, Bethaprim, Uroplus DS, Bethaprim Pediatric, Cotrim Pediatric)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramahexal, ConZip, Larapam SR, Ryzolt, Tramal SR, GenRx Tramadol, Tramahexal SR, Tramedo, Zydol, Zamadol, Zydol XL, Rybix ODT, Ultram ODT)
  • valganciclovir (Valcyte)

Co-trimoxazole (sulfamethoxazole / trimethoprim) alcohol/food interactions

There is 1 alcohol/food interaction with Co-trimoxazole (sulfamethoxazole / trimethoprim)

Co-trimoxazole (sulfamethoxazole / trimethoprim) disease interactions

There are 12 disease interactions with Co-trimoxazole (sulfamethoxazole / trimethoprim) which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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