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Co-trimoxazole (sulfamethoxazole / trimethoprim) Drug Interactions

A total of 503 drugs are known to interact with Co-trimoxazole (sulfamethoxazole / trimethoprim).

  • 112 major drug interactions
  • 167 moderate drug interactions
  • 224 minor drug interactions

Show all medications in the database that may interact with Co-trimoxazole (sulfamethoxazole / trimethoprim).

Check for interactions with Co-trimoxazole (sulfamethoxazole / trimethoprim)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Co-trimoxazole (sulfamethoxazole / trimethoprim)

  • acyclovir (Zovirax, Sitavig)
  • amlodipine (Norvasc)
  • amoxicillin (Amoxil, Trimox, Moxilin, Amoxicot, Apo-Amoxi, Moxatag, DisperMox, Wymox, Biomox)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Ecotrin Adult Low Strength, Bufferin, Aspiritab, Arthritis Pain, Fasprin, Halfprin, Easprin, Durlaza, Aspirtab, St. Joseph 81 mg Chewable Aspirin, Aspergum, Low Dose ASA, Buffered Aspirin, Ecotrin Maximum Strength, Ascriptin Enteric, Acuprin 81, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Aspirin Lite Coat, Bayer Aspirin Regimen, Aspi-Cor, Empirin, Bayer Children's Aspirin, Bufferin Extra Strength, St. Joseph Aspirin, Bayer Women's Aspirin With Calcium, Miniprin, Migralex, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Bayer Aspirin Extra Strength Plus, Buffex, Entercote, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, Ecpirin, Zero-Order Release, YSP Aspirin, Heartline, Bayer Advanced Aspirin, Buffasal)
  • bisoprolol (Zebeta)
  • ciprofloxacin (Cipro, Cipro I.V., Cipro Cystitis Pack, Cipro XR, Proquin XR)
  • clarithromycin (Biaxin, Biaxin XL)
  • fluconazole (Diflucan)
  • folic acid (Folvite, FA-8, Folacin-800, FaLessa)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Proprinal, Motrin IB, Children's Motrin, IBU-200, Advil Migraine, Ibu-8, Motrin Childrens, Nuprin, Motrin Migraine Pain, Ibuprofen PMR, NeoProfen, Caldolor, Advil Children's, Addaprin, Motrin Infant Drops, Advil Infant's Concentrated Drops, Rufen, Genpril, A-G Profen, Ibu-Tab, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, Childrens Ibuprofen Berry, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • methotrexate (Rasuvo, Trexall, Otrexup, Methotrexate LPF Sodium, Xatmep, Rheumatrex Dose Pack, Folex PFS)
  • metronidazole (Flagyl, Flagyl IV, Metro, Metro IV, Flagyl 375, Protostat, Metryl, Flagyl ER)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • ondansetron (Zofran, Zofran ODT, Zuplenz)
  • Paracetamol (acetaminophen)
  • prednisolone (Prelone, Orapred, Millipred, Orapred ODT, PediaPred, Predalone 50, Flo-Pred, Veripred 20, AsmalPred Plus, Delta-Cortef, Hydeltra-TBA, Hydeltrasol, Key-Pred, Cotolone, Predicort-50, Predacort 50, Predate-50, Predaject-50, Pred-Ject-50, Key-Pred SP, Medicort, Predicort RP, Pri-Cortin 50, Predcor, Bubbli-Pred, Millipred DP)
  • prednisone (Deltasone, Rayos, Sterapred, Sterapred DS, Prednicot, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • ranitidine (Zantac, Zantac 150, Zantac 75, Zantac 300, Deprizine, Zantac Injection, Acid Reducer, Zantac 150 EFFERdose, Taladine, Zantac 25 mg EFFERdose, Berkley and Jensen Acid Reducer Maximum Strength, Zantac GELdose, Zantac 300 GELdose, Zantac EFFERdose, Acid Reducer Non-Prescription Strength, Acid Relief, Sunmark Acid Reducer Maximum Strength, Acid Control 75, Careone Acid Reducer, Equaline Heartburn Relief, Acid Control 150)
  • sulfamethoxazole / trimethoprim (Bactrim, Bactrim DS, Septra, SMZ-TMP DS, Septra DS, Co-trimoxazole, Sulfatrim, Sulfatrim Pediatric, Cotrim, Bactrim Pediatric, Bactrim IV, Bethaprim, Uroplus, Uroplus DS, Cotrim DS, Septra IV, Bethaprim Pediatric, Cotrim Pediatric)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Larapam SR, Tramedo, Ryzolt, GenRx Tramadol, ConZip, Zydol, Tramal SR, Tramahexal, Zamadol, Tramahexal SR, Zydol XL, Rybix ODT, Ultram ODT)
  • valganciclovir (Valcyte)

Co-trimoxazole (sulfamethoxazole / trimethoprim) alcohol/food interactions

There is 1 alcohol/food interaction with Co-trimoxazole (sulfamethoxazole / trimethoprim)

Co-trimoxazole (sulfamethoxazole / trimethoprim) disease interactions

There are 12 disease interactions with Co-trimoxazole (sulfamethoxazole / trimethoprim) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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