Drug Interactions between simvastatin and Xarelto
This report displays the potential drug interactions for the following 2 drugs:
- Xarelto (rivaroxaban)
Interactions between your drugs
No interactions were found between simvastatin and Xarelto. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
- Simvastatin is in the drug class statins.
Simvastatin is used to treat the following conditions:
- Cardiovascular Risk Reduction
- High Cholesterol
- High Cholesterol, Familial Heterozygous
- High Cholesterol, Familial Homozygous
- Hyperlipoproteinemia Type IIa, Elevated LDL
- Hyperlipoproteinemia Type IIb, Elevated LDL VLDL
- Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL
- Hyperlipoproteinemia Type IV, Elevated VLDL
- Prevention of Cardiovascular Disease
- Xarelto is in the drug class factor Xa inhibitors.
Xarelto is used to treat the following conditions:
- Atrial Fibrillation
- Cardiovascular Risk Reduction
- Coronary Artery Disease
- Deep Vein Thrombosis
- Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery
- Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery
- Deep Vein Thrombosis, Prophylaxis
- Deep Vein Thrombosis, Recurrent Event
- Peripheral Arterial Disease
- Prevention of Thromboembolism in Atrial Fibrillation
- Pulmonary Embolism
- Pulmonary Embolism, Recurrent Event
Drug and food interactions
Applies to: simvastatin
Grapefruit juice can significantly increase the blood levels of simvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death. You should avoid the consumption of grapefruit or grapefruit juice during treatment with simvastatin. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness during treatment, especially if these symptoms are accompanied by fever or dark colored urine. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.