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Ivacaftor / lumacaftor Drug Interactions

A total of 606 drugs are known to interact with ivacaftor / lumacaftor.

  • 268 major drug interactions
  • 330 moderate drug interactions
  • 8 minor drug interactions

Show all medications in the database that may interact with ivacaftor / lumacaftor.

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Type in a drug name to check for interactions with ivacaftor / lumacaftor.

Medications known to interact with ivacaftor / lumacaftor

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    • edoxaban (Savaysa)
    • efavirenz (Sustiva)
    • efavirenz / emtricitabine / tenofovir (Atripla)
    • efavirenz / lamivudine / tenofovir (Symfi, Symfi Lo)
    • elagolix (Orilissa)
    • elbasvir / grazoprevir (Zepatier)
    • eletriptan (Relpax)
    • eliglustat (Cerdelga)
    • eluxadoline (Viberzi)
    • elvitegravir (Vitekta)
    • empagliflozin / linagliptin (Glyxambi)
    • emtricitabine / lopinavir / ritonavir / tenofovir (AccessPak for HIV PEP Expanded with Kaletra)
    • emtricitabine / nelfinavir / tenofovir (AccessPak for HIV PEP Expanded with Viracept)
    • enalapril / felodipine (Lexxel)
    • encorafenib (Braftovi)
    • enzalutamide (Xtandi)
    • ephedrine / phenobarbital / potassium iodide / theophylline (Quadrinal)
    • ephedrine / phenobarbital / theophylline (Tedrigen, Theodrine)
    • epinephrine / lidocaine (Xylocaine with Epinephrine, Xylocaine-MPF-Epinephrine, Lignospan, Octocaine 100, Xylocaine HCl with Epinephrine, Xylocaine with Epinephrine Dental Cartridges, Lignospan Forte, Xylocaine Dental, LidoSite)
    • epirubicin (Ellence, Pharmorubicin PFS, Pharmorubicin RDF)
    • eplerenone (Inspra)
    • eravacycline (Xerava)
    • ergonovine (Ergotrate, Ergotrate Maleate)
    • ergotamine (Ergomar)
    • erlotinib (Tarceva)
    • erythromycin (Erythrocin, E-Mycin, EryPed, Ery-Tab, Ilosone, Eryc, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, Robimycin, PCE Dispertab, Wyamycin S, E.E.S. Granules, E.E.S.-200, E.E.S.-400, E.E.S.-400 Filmtab, Erythrocot, MY-E)
    • erythromycin / sulfisoxazole (Pediazole, Eryzole, Sulfimycin, E S P)
    • escitalopram (Lexapro)
    • eslicarbazepine (Aptiom)
    • esomeprazole (Nexium, Nexium 24HR, Nexium IV)
    • esomeprazole / naproxen (Vimovo)
    • estazolam (Prosom)
    • esterified estrogens (Menest, Estratab)
    • esterified estrogens / methyltestosterone (Estratest, Covaryx, Estratest H.S., Syntest HS, Essian, Covaryx HS, EEMT HS, EEMT, Menogen HS, Menogen, Syntest DS, Essian H.S., EEMT DS)
    • estradiol (Estrace, Estradiol Patch, Climara, Vivelle-Dot, Minivelle, Estrogel, Vivelle, Estrogen Patches, Femring, Divigel, Delestrogen, Estrofem, Estraderm, Evamist, Alora, Elestrin, Progynova, Estradot, Elleste Solo, Depo-Estradiol, Valergen, Primogyn Depot, Oestradiol Implants, Oesclim, Estradot 37.5, Oestrogel Pump-Pack, Dermestril, Evorel, Aerodiol, Sandrena, Fematrix, Nuvelle TS Phase I, FemTab, Estrasorb, Femtran, Climodien, Organon Oestradiol, Estradiol G GAM, Provames, Thaissept, Estra Pellets, Depogen, Dep Gynogen, Gynogen LA 20, Dioval 40, Dioval XX, Duragen, Estra-C, Estra-V 40, Estro-Cyp, Gynodiol, Estro-Span 40, Medidiol 10, Dura-Estrin, Fempatch, Esclim, Estragyn LA 5, Clinagen LA 40, Estro-LA, Menaval-20, Estradot 50, Estradot 75, Estradot 100, FemSeven, Progynova TS, Zumenon, Adgyn Estro, FemSeven Sequi Phase I, Menorest Patch, Climaval, Bedol, Delidose, Dermestril Septem, Estrapatch, Estreva, Femsept, Menorest, Oestrodose, Oestrogel, Oromone, Systen, Thais, Dotti, Menostar, Femtrace)
    • estradiol topical (Vagifem, Yuvafem, Estrace Vaginal Cream, Estring, Imvexxy)
    • estradiol / levonorgestrel (Climara Pro)
    • estradiol / medroxyprogesterone (Lunelle)
    • estradiol / norethindrone (CombiPatch, Activella, Mimvey, Amabelz, Lopreeza, Ena, Mimvey Lo)
    • estradiol / norethindrone topical
    • estradiol / norgestimate (Prefest, Ortho-Prefest)
    • estradiol / progesterone (Bijuva)
    • estradiol / testosterone (Depotestogen, Depo-Testadiol, Dep Androgyn, Delatestadiol, Estra-Testrin, Valertest No 1, Duo-Cyp, Dura-Dumone, Duratestrin)
    • estrone (Estrone AQ, Kestrone 5, Estragyn 5, Aquest, Estro-A)
    • estropipate (Ogen, Ogen 1.25, Ortho-Est, Ogen 0.625, Ogen 2.5)
    • estropipate topical (Ogen Vaginal Cream)
    • eszopiclone (Lunesta)
    • ethinyl estradiol (Estinyl)
    • ethinyl estradiol / ethynodiol (Kelnor 1/35, Zovia 1/35E, Zovia 1/50E, Demulen, Demulen 1/35, Demulen 1/50, Kelnor 1/50, Lo-Malmorede, Malmorede)
    • ethinyl estradiol / etonogestrel (NuvaRing)
    • ethinyl estradiol / folic acid / levonorgestrel (FaLessa Kit)
    • ethinyl estradiol / levonorgestrel (Aviane, Alesse, Seasonique, Lutera, Levora, Seasonale, Orsythia, Lessina, Sronyx, Aubra, Introvale, Amethia, Portia, Amethyst, Falmina, Kurvelo, Daysee, Altavera, Vienva, Trivora, Camrese, Ashlyna, Jolessa, Larissia, Levlen, Setlakin, Marlissa, Balcoltra, Alesse-28, Quasense, Lillow, LoSeasonique, Chateal, Lybrel, Simpesse, Levonest, Fayosim, Afirmelle, Nordette, Triphasil, Amethia Lo, Chateal EQ, Quartette, Ayuna, Jaimiess, Alesse-21, Levlite, Preven EC, Enpresse, CamreseLo, Delyla, Aubra EQ, Rivelsa, Lo Simpesse, Cerinta, Nordette-21, Elifemme, Nordette-28, Tri-Levlen, Triphasil-21, Triphasil-28, Sylevia, Triquilar 21, Triquilar 28, Min-Ovral 21, Min-Ovral 28, Myzilra, Iclevia)
    • ethinyl estradiol / norelgestromin (Xulane, Ortho Evra)
    • ethinyl estradiol / norethindrone (Lo Loestrin Fe, Junel Fe 1/20, Necon 1/35, Microgestin Fe 1/20, Taytulla, Minastrin 24 Fe, Loestrin 21 1/20, Nortrel 1/35, Blisovi 24 Fe, Estrostep Fe, Junel 1.5/30, Loestrin 24 Fe, Loestrin Fe 1/20, Loestrin Fe 1.5/30, Larin Fe 1/20, Junel Fe 24, Microgestin 1.5/30, Blisovi Fe 1/20, Jinteli, Melodetta 24 Fe, Mibelas 24 Fe, Ortho-Novum 7/7/7, Junel 1/20, Junel Fe 1.5/30, Pirmella 1/35, Ortho-Novum 1/35, Alyacen 1/35, femhrt, Tarina Fe 1/20, Necon 7/7/7, Microgestin 1/20, Fyavolv, Tilia Fe, Blisovi Fe 1.5/30, Layolis Fe, Wymzya Fe, Cyclafem 1/35, Brevicon, Aranelle, Nortrel 0.5/35, Gildess Fe 1/20, Necon 10/11, Microgestin Fe 1.5/30, Balziva, Kaitlib Fe, Dasetta, Larin Fe 1.5/30, Vyfemla, Generess Fe, Larin 24 Fe, Hailey 24 Fe, Pirmella 7/7/7, Modicon, Norethin 1/35 E, Loestrin 21 1.5/30, Nelova 1/35, Necon 0.5/35, Tri-Norinyl, Nortrel 7/7/7, Leena, Zenchent Fe, Nylia 1/35, Tarina 24 Fe, Gildagia, Tri-Legest Fe, Philith, Microgestin 24 Fe, Larin 1.5/30, Larin 1/20, Gildess 24 Fe, Jevantique, Hailey Fe 1/20, Wera, Cyclafem 7/7/7, Ovcon 35, Genora 0.5/35, Nelova 0.5/35, Gildess Fe 1.5/30, Norinyl 1+35, Genora 1/35, Nelova 10/11, Ovcon 50, Jenest, Ortho-Novum 10/11, Ovcon 35 Fe, Femcon Fe, Nylia 7/7/7, Zenchent, Cyonanz, Aurovela Fe 1.5/30, Aurovela 24 Fe, Aurovela Fe 1/20, Aurovela 1/20, Leribane, Aurovela 1.5/30, Cyclafem 0.5/35, Tri-Legest, Lo Minastrin Fe, Briellyn, Lomedia 24 Fe, Dasetta 7/7/7, Dasetta 1/35, Zeosa, Hailey 1.5/30, Hailey Fe 1.5/30, Nexesta Fe, Alyacen 7/7/7, Gildess 1.5/30, Gildess 1/20, Jevantique Lo)
    • ethinyl estradiol / norgestimate (Sprintec, Ortho Tri-Cyclen, TriNessa, Tri-Sprintec, Estarylla, Ortho Tri-Cyclen Lo, Mononessa, Ortho Cyclen, Tri-Lo-Sprintec, Femynor, Tri-Lo-Estarylla, TriNessa Lo, Tri-Estarylla, Tri-Linyah, Mili, Tri-Lo-Marzia, Tri-Previfem, Previfem, Mono-Linyah, VyLibra, Tri-VyLibra, Tri-Vylibra Lo, Tri Femynor, Tri-Lo-Mili, Tri-Mili)
    • ethinyl estradiol / norgestrel (Cryselle, Elinest, Ogestrel 0.5/50, Low-Ogestrel-28, Ovral, Lo/Ovral, Lo/Ovral-28, Ovral-21, Ovral-28)
    • ethinyl estradiol / segesterone (Annovera)
    • ethosuximide (Zarontin)
    • etonogestrel (Nexplanon, Implanon)
    • etoposide (Toposar, VePesid, Etopophos)
    • etravirine (Intelence)
    • everolimus (Afinitor, Zortress, Afinitor Disperz)
    • exemestane (Aromasin)
    • ezetimibe / simvastatin (Vytorin)
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    • lansoprazole (Prevacid, Prevacid SoluTab, Prevacid OTC, Prevacid 24HR, Prevacid IV)
    • lansoprazole / naproxen (Prevacid NapraPAC, Prevacid NapraPAC 500, Prevacid NapraPAC 375)
    • lapatinib (Tykerb)
    • larotrectinib (Vitrakvi)
    • leflunomide (Arava)
    • letermovir (Prevymis)
    • letrozole (Femara)
    • letrozole / ribociclib (Kisqali Femara Co-Pack)
    • leuprolide / norethindrone (Lupaneta Pack)
    • levomethadyl acetate (Orlaam)
    • levonorgestrel (Mirena, Plan B, Skyla, Plan B One-Step, Kyleena, Liletta, New Day, Aftera, Take Action, My Way, Preventeza, EContra One-Step, Norplant System, My Choice, EContra EZ, Her Style, Option 2, Athentia Next, Morning After, AfterPill, Next Choice One Dose, React, Fallback Solo, Next Choice, Opcicon One-Step)
    • lidocaine (Xylocaine-MPF, Xylocaine Dental Cartridges, Nervocaine, UAD Caine, Xylocaine HCl, Lidoject 1, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Truxacaine, Anestacaine, DentiPatch)
    • lidocaine / oxytetracycline (Terramycin IM)
    • lidocaine / potassium chloride
    • lidocaine / sodium bicarbonate
    • linagliptin (Tradjenta)
    • linagliptin / metformin (Jentadueto, Jentadueto XR)
    • lomitapide (Juxtapid)
    • loperamide (Imodium, Imodium A-D, Anti-Diarrheal, Kaopectate II, Neo-Diaral, Pepto Diarrhea Control, Imotil, Kao-Paverin, Diar-Aid, Diamode, Up and Up Anti-Diarrheal Solution, Kaopectate 1-D, A-D Anti-Diarrheal)
    • loperamide / simethicone (Anti-Diarrheal + Anti-Gas, Imodium Multi-Symptom Relief)
    • lopinavir / ritonavir (Kaletra)
    • loratadine (Claritin, Alavert, Claritin 24 Hour Allergy, Claritin Reditabs, Wal-itin, Loratadine Reditab, Allergy Relief Tablets, Children's Claritin Allergy, Allergy Relief 24 Hour, Help I Have Allergies, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND)
    • loratadine / pseudoephedrine (Claritin-D, Loratadine-D 24 Hour, Loratadine-D 12 Hour, Claritin-D 24 Hour, Claritin-D 12 Hour, Alavert D-12 Hour Allergy and Sinus, AllerClear D-24 Hour, Clear-Atadine-D, Allergy Relief D12, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour)
    • lorlatinib (Lorbrena)
    • lovastatin (Mevacor, Altocor, Altoprev)
    • lovastatin / niacin (Advicor)
    • lurasidone (Latuda)
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    Ivacaftor / lumacaftor alcohol/food interactions

    There are 2 alcohol/food interactions with ivacaftor / lumacaftor

    Ivacaftor / lumacaftor disease interactions

    There are 6 disease interactions with ivacaftor / lumacaftor which include:

    Drug Interaction Classification

    These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
    Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
    Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
    Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
    Unknown No interaction information available.

    Further information

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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