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Ivacaftor / lumacaftor Drug Interactions

A total of 602 drugs are known to interact with ivacaftor / lumacaftor.

  • 251 major drug interactions
  • 344 moderate drug interactions
  • 7 minor drug interactions

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Type in a drug name to check for interactions with ivacaftor / lumacaftor.

Medications known to interact with ivacaftor / lumacaftor

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    • edoxaban (Savaysa)
    • efavirenz (Sustiva)
    • efavirenz / emtricitabine / tenofovir (Atripla)
    • efavirenz / lamivudine / tenofovir (Symfi Lo, Symfi)
    • elagolix (Orilissa)
    • elbasvir / grazoprevir (Zepatier)
    • eletriptan (Relpax)
    • eliglustat (Cerdelga)
    • eluxadoline (Viberzi)
    • elvitegravir (Vitekta)
    • empagliflozin / linagliptin (Glyxambi)
    • emtricitabine / lopinavir / ritonavir / tenofovir (AccessPak for HIV PEP Expanded with Kaletra)
    • emtricitabine / nelfinavir / tenofovir (AccessPak for HIV PEP Expanded with Viracept)
    • enalapril / felodipine (Lexxel)
    • encorafenib (Braftovi)
    • enzalutamide (Xtandi)
    • ephedrine / phenobarbital / potassium iodide / theophylline (Quadrinal)
    • ephedrine / phenobarbital / theophylline (Tedrigen, Theodrine)
    • epinephrine / lidocaine (Xylocaine-MPF-Epinephrine, Xylocaine with Epinephrine, Lignospan Forte, Xylocaine HCl with Epinephrine, Xylocaine with Epinephrine Dental Cartridges, Lignospan, Octocaine 100, Xylocaine Dental, LidoSite)
    • epirubicin (Ellence, Pharmorubicin PFS, Pharmorubicin RDF)
    • eplerenone (Inspra)
    • eravacycline (Xerava)
    • ergonovine (Ergotrate, Ergotrate Maleate)
    • ergotamine (Ergomar)
    • erlotinib (Tarceva)
    • erythromycin (Erythrocin, E-Mycin, Ery-Tab, EryPed, Ilosone, Eryc, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, Robimycin, PCE Dispertab, Wyamycin S, E.E.S. Granules, E.E.S.-200, E.E.S.-400, E.E.S.-400 Filmtab, Erythrocot, MY-E)
    • erythromycin / sulfisoxazole (Pediazole, Eryzole, Sulfimycin, E S P)
    • escitalopram (Lexapro)
    • eslicarbazepine (Aptiom)
    • esomeprazole (Nexium, Nexium 24HR, Nexium IV)
    • esomeprazole / naproxen (Vimovo)
    • estazolam (Prosom)
    • esterified estrogens (Menest, Estratab)
    • esterified estrogens / methyltestosterone (Estratest, Covaryx, EEMT, EEMT HS, Estratest H.S., Syntest HS, Essian, Covaryx HS, Menogen HS, Menogen, Syntest DS, Essian H.S., EEMT DS)
    • estradiol (Estrace, Estradiol Patch, Climara, Minivelle, Estrogel, Vivelle-Dot, Divigel, Estrogen Patches, Vivelle, Femring, Alora, Delestrogen, Progynova, Evamist, Elestrin, Estraderm, Estradot, Oestrogel, Menostar, Estragyn LA 5, Fematrix, Estrofem, Estradiol G GAM, Estreva, Depo-Estradiol, Depogen, Estra-C, Oesclim, Menaval-20, Oestrogel Pump-Pack, Evorel, Aerodiol, Estrasorb, Femtran, Primogyn Depot, Oestradiol Implants, Valergen, Dep Gynogen, Gynogen LA 20, Dioval 40, Dioval XX, Duragen, Estra-V 40, Estro-Cyp, Gynodiol, Estro-Span 40, Medidiol 10, Dura-Estrin, Fempatch, Esclim, Clinagen LA 40, Estro-LA, Estradot 37.5, Estradot 50, Estradot 75, Estradot 100, Dermestril, FemSeven, Progynova TS, Sandrena, Elleste Solo, Zumenon, Adgyn Estro, FemSeven Sequi Phase I, Menorest Patch, Nuvelle TS Phase I, Climaval, FemTab, Climodien, Organon Oestradiol, Bedol, Delidose, Dermestril Septem, Estrapatch, Femsept, Menorest, Oestrodose, Oromone, Provames, Systen, Thais, Thaissept, Dotti, Estra Pellets, Femtrace)
    • estradiol topical (Vagifem, Estrace Vaginal Cream, Yuvafem, Estring, Imvexxy)
    • estradiol / levonorgestrel (Climara Pro)
    • estradiol / medroxyprogesterone (Lunelle)
    • estradiol / norethindrone (CombiPatch, Activella, Mimvey, Amabelz, Lopreeza, Mimvey Lo, Ena)
    • estradiol / norethindrone topical
    • estradiol / norgestimate (Prefest, Ortho-Prefest)
    • estradiol / progesterone (Bijuva)
    • estradiol / testosterone (Depo-Testadiol, Depotestogen, Dep Androgyn, Delatestadiol, Estra-Testrin, Valertest No 1, Duo-Cyp, Dura-Dumone, Duratestrin)
    • estrone (Estrone AQ, Kestrone 5, Estragyn 5, Aquest, Estro-A)
    • estropipate (Ogen, Ogen 0.625, Ortho-Est, Ogen 1.25, Ogen 2.5)
    • estropipate topical (Ogen Vaginal Cream)
    • eszopiclone (Lunesta)
    • ethinyl estradiol (Estinyl)
    • ethinyl estradiol / ethynodiol (Kelnor 1/35, Zovia 1/35E, Demulen 1/35, Demulen, Demulen 1/50, Kelnor 1/50, Lo-Malmorede, Zovia 1/50E, Malmorede)
    • ethinyl estradiol / etonogestrel (NuvaRing)
    • ethinyl estradiol / folic acid / levonorgestrel (FaLessa Kit)
    • ethinyl estradiol / levonorgestrel (Aviane, Alesse, Seasonique, Levora, Seasonale, Lutera, Aubra, Portia, Ashlyna, Orsythia, Vienva, Amethyst, Amethia, Jolessa, Sronyx, Camrese, Daysee, Lessina, Larissia, Altavera, Trivora, Triphasil, Levlen, Lillow, Falmina, Alesse-28, Chateal, Introvale, Kurvelo, LoSeasonique, Quasense, Nordette, Chateal EQ, Lybrel, Setlakin, Simpesse, Balcoltra, Amethia Lo, Enpresse, Rivelsa, Levonest, Jaimiess, Nordette-21, Alesse-21, Levlite, Preven EC, Myzilra, Delyla, Aubra EQ, Marlissa, Quartette, Ayuna, Lo Simpesse, Fayosim, Cerinta, Afirmelle, Elifemme, Nordette-28, Tri-Levlen, Triphasil-21, Triphasil-28, Sylevia, Triquilar 21, Triquilar 28, Min-Ovral 21, Min-Ovral 28, CamreseLo, Iclevia)
    • ethinyl estradiol / norelgestromin (Xulane, Ortho Evra)
    • ethinyl estradiol / norethindrone (Lo Loestrin Fe, Junel Fe 1/20, Taytulla, Necon 1/35, Microgestin Fe 1/20, Loestrin Fe 1/20, Blisovi 24 Fe, Estrostep Fe, Nortrel 1/35, Minastrin 24 Fe, Junel 1.5/30, Junel Fe 1.5/30, Blisovi Fe 1.5/30, Loestrin 21 1/20, Mibelas 24 Fe, Loestrin Fe 1.5/30, Junel 1/20, Blisovi Fe 1/20, Junel Fe 24, Tarina Fe 1/20, Microgestin 1.5/30, Loestrin 24 Fe, femhrt, Layolis Fe, Cyclafem 1/35, Jinteli, Microgestin 1/20, Balziva, Melodetta 24 Fe, Wymzya Fe, Ortho-Novum 1/35, Necon 0.5/35, Necon 10/11, Microgestin Fe 1.5/30, Necon 7/7/7, Femcon Fe, Kaitlib Fe, Alyacen 1/35, Larin Fe 1.5/30, Brevicon, Norinyl 1+35, Loestrin 21 1.5/30, Ovcon 50, Nortrel 7/7/7, Leena, Tri-Legest, Tri-Legest Fe, Larin Fe 1/20, Generess Fe, Larin 24 Fe, Jevantique, Hailey 24 Fe, Wera, Pirmella 7/7/7, Pirmella 1/35, Ovcon 35, Ortho-Novum 7/7/7, Tri-Norinyl, Jenest, Ortho-Novum 10/11, Aranelle, Zenchent Fe, Nortrel 0.5/35, Zenchent, Aurovela Fe 1.5/30, Aurovela Fe 1/20, Tarina 24 Fe, Fyavolv, Tilia Fe, Briellyn, Dasetta, Alyacen 7/7/7, Gildess 1/20, Vyfemla, Gildess 24 Fe, Hailey Fe 1/20, Modicon, Cyclafem 7/7/7, Genora 0.5/35, Nelova 0.5/35, Gildess Fe 1.5/30, Gildess Fe 1/20, Genora 1/35, Norethin 1/35 E, Nelova 10/11, Nelova 1/35, Ovcon 35 Fe, Nylia 7/7/7, Cyonanz, Nylia 1/35, Aurovela 24 Fe, Aurovela 1/20, Leribane, Aurovela 1.5/30, Cyclafem 0.5/35, Lo Minastrin Fe, Gildagia, Lomedia 24 Fe, Dasetta 7/7/7, Philith, Dasetta 1/35, Zeosa, Hailey 1.5/30, Hailey Fe 1.5/30, Nexesta Fe, Gildess 1.5/30, Microgestin 24 Fe, Larin 1.5/30, Larin 1/20, Jevantique Lo)
    • ethinyl estradiol / norgestimate (Sprintec, Ortho Tri-Cyclen, Tri-Sprintec, TriNessa, Ortho Tri-Cyclen Lo, Estarylla, Ortho Cyclen, Mononessa, Mono-Linyah, Tri-Lo-Sprintec, Femynor, TriNessa Lo, Tri-Lo-Marzia, Previfem, Tri-Lo-Estarylla, VyLibra, Tri-Linyah, Mili, Tri-Previfem, Tri Femynor, Tri-Estarylla, Tri-VyLibra, Tri-Vylibra Lo, Tri-Lo-Mili, Tri-Mili)
    • ethinyl estradiol / norgestrel (Cryselle, Low-Ogestrel-28, Lo/Ovral, Ovral, Elinest, Ogestrel 0.5/50, Lo/Ovral-28, Ovral-28, Ovral-21)
    • ethinyl estradiol / segesterone (Annovera)
    • ethosuximide (Zarontin)
    • etonogestrel (Nexplanon, Implanon)
    • etoposide (VePesid, Toposar, Etopophos)
    • etravirine (Intelence)
    • everolimus (Afinitor, Zortress, Afinitor Disperz)
    • exemestane (Aromasin)
    • ezetimibe / simvastatin (Vytorin)
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    • lansoprazole (Prevacid, Prevacid SoluTab, Prevacid OTC, Prevacid 24HR, Prevacid IV)
    • lansoprazole / naproxen (Prevacid NapraPAC 500, Prevacid NapraPAC, Prevacid NapraPAC 375)
    • lapatinib (Tykerb)
    • larotrectinib (Vitrakvi)
    • leflunomide (Arava)
    • letermovir (Prevymis)
    • letrozole (Femara)
    • letrozole / ribociclib (Kisqali Femara Co-Pack)
    • leuprolide / norethindrone (Lupaneta Pack)
    • levomethadyl acetate (Orlaam)
    • levonorgestrel (Mirena, Plan B, Plan B One-Step, Skyla, Kyleena, Liletta, Take Action, Aftera, My Way, Morning After, New Day, EContra One-Step, Next Choice, AfterPill, My Choice, Next Choice One Dose, React, EContra EZ, Her Style, Option 2, Athentia Next, Norplant System, Preventeza, Fallback Solo, Opcicon One-Step)
    • lidocaine (Xylocaine-MPF, Xylocaine HCl, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, UAD Caine, Anestacaine, DentiPatch)
    • lidocaine / oxytetracycline (Terramycin IM)
    • lidocaine / potassium chloride
    • lidocaine / sodium bicarbonate
    • linagliptin (Tradjenta)
    • linagliptin / metformin (Jentadueto, Jentadueto XR)
    • lomitapide (Juxtapid)
    • loperamide (Imodium, Imodium A-D, Anti-Diarrheal, Pepto Diarrhea Control, Diamode, Kaopectate II, Neo-Diaral, Imotil, Kao-Paverin, Diar-Aid, Up and Up Anti-Diarrheal Solution, Kaopectate 1-D, A-D Anti-Diarrheal)
    • loperamide / simethicone (Imodium Multi-Symptom Relief, Anti-Diarrheal + Anti-Gas)
    • lopinavir / ritonavir (Kaletra)
    • loratadine (Claritin, Alavert, Claritin 24 Hour Allergy, Loratadine Reditab, Allergy Relief Tablets, Allergy Relief 24 Hour, Claritin Reditabs, Wal-itin, Children's Allergy Relief 24 Hour, Vicks QlearQuil All Day & All Night 24 Hour Allergy Relief, Help I Have Allergies, ohm Allergy Relief, Clear-Atadine, Claritin Hives Relief, Dimetapp Children's ND Non-Drowsy Allergy, Clear-Atadine Children's, Bactimicina Allergy, Tavist ND, Children's Claritin Allergy)
    • loratadine / pseudoephedrine (Claritin-D, Loratadine-D 24 Hour, Loratadine-D 12 Hour, Claritin-D 24 Hour, Alavert D-12 Hour Allergy and Sinus, Claritin-D 12 Hour, AllerClear D-24 Hour, Clear-Atadine-D, Allergy Relief D12, Leader Allergy Relief D-24, Allergy & Congestion Relief, Allergy Relief D 24 Hour)
    • lorlatinib (Lorbrena)
    • lovastatin (Mevacor, Altoprev, Altocor)
    • lovastatin / niacin (Advicor)
    • lurasidone (Latuda)
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    Ivacaftor / lumacaftor alcohol/food interactions

    There is 1 alcohol/food interaction with ivacaftor / lumacaftor

    Ivacaftor / lumacaftor disease interactions

    There are 3 disease interactions with ivacaftor / lumacaftor which include:

    Drug Interaction Classification

    These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
    Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
    Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
    Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
    Unknown No interaction information available.

    Further information

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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