Guaifenesin/hydrocodone/phenylephrine Drug Interactions
Currently displaying a list of 729 drugs known to interact with guaifenesin / hydrocodone / phenylephrine.
- 231 major drug interactions
- 495 moderate drug interactions
- 3 minor drug interactions
Medications known to interact with guaifenesin/hydrocodone/phenylephrine
Note: Showing generic names only.
- abametapir topical
- abiraterone
- acarbose
- acebutolol
- acetohexamide
- acetylcarbromal
- acrivastine
- adalimumab
- albiglutide
- albuterol
- aldesleukin
- alefacept
- alfentanil
- alfuzosin
- allopurinol
- almotriptan
- alogliptin
- alprazolam
- alvimopan
- amifampridine
- amiloride
- aminoglutethimide
- aminophylline
- amiodarone
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amprenavir
- amyl nitrite
- anakinra
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- aprocitentan
- arformoterol
- aripiprazole
- armodafinil
- asciminib
- asenapine
- atazanavir
- atenolol
- atezolizumab
- atomoxetine
- atropine
- atropine ophthalmic
- attapulgite
- avacopan
- avelumab
- azatadine
- azelastine nasal
- azilsartan medoxomil
- baclofen
- baricitinib
- belladonna
- belzutifan
- benazepril
- bendroflumethiazide
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betaxolol
- betaxolol ophthalmic
- bexagliflozin
- bexarotene
- bimekizumab
- biperiden
- bismuth subgallate
- bismuth subsalicylate
- bisoprolol
- bitolterol
- blinatumomab
- boceprevir
- bosentan
- brexanolone
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
- caffeine
- canagliflozin
- canakinumab
- candesartan
- cannabidiol
- cannabis
- capivasertib
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carteolol ophthalmic
- carvedilol
- celecoxib
- cemiplimab
- cenobamate
- ceritinib
- cetirizine
- chlophedianol
- chloral hydrate
- chloramphenicol
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chlorzoxazone
- cimetidine
- ciprofloxacin
- citalopram
- clarithromycin
- clemastine
- clevidipine
- clidinium
- clobazam
- clofazimine
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clotrimazole
- clozapine
- cobicistat
- cocaine nasal
- cocaine topical
- codeine
- colchicine
- conivaptan
- cosibelimab
- crizotinib
- cyclizine
- cyclobenzaprine
- cyclopentolate ophthalmic
- cyproheptadine
- dabrafenib
- dantrolene
- dapagliflozin
- daridorexant
- darifenacin
- darunavir
- deferasirox
- delavirdine
- deserpidine
- desflurane
- desipramine
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dicyclomine
- diethylpropion
- difelikefalin
- digitoxin
- digoxin
- dihydroergotamine
- diltiazem
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- dobutamine
- dolasetron
- dopamine
- dostarlimab
- doxapram
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- droxidopa
- dulaglutide
- duloxetine
- durvalumab
- duvelisib
- echinacea
- efavirenz
- elafibranor
- elagolix
- eletriptan
- elranatamab
- eluxadoline
- emapalumab
- empagliflozin
- enalapril
- enalaprilat
- encorafenib
- enflurane
- entacapone
- entrectinib
- enzalutamide
- epcoritamab
- ephedrine
- epinephrine
- eplerenone
- epoprostenol
- eprosartan
- erdafitinib
- ergonovine
- ergotamine
- ertugliflozin
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethosuximide
- ethotoin
- etravirine
- evening primrose
- exenatide
- ezogabine
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenoldopam
- fentanyl
- fesoterodine
- fexinidazole
- flavoxate
- flibanserin
- fluconazole
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- formoterol
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fospropofol
- fostamatinib
- frovatriptan
- furazolidone
- furosemide
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gepirone
- ginkgo
- glimepiride
- glipizide
- glofitamab
- glyburide
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- golimumab
- granisetron
- griseofulvin
- guanabenz
- guanadrel
- guanethidine
- guanfacine
- guselkumab
- halazepam
- haloperidol
- halothane
- heroin
- homatropine ophthalmic
- hyaluronidase
- hydralazine
- hydrochlorothiazide
- hydroflumethiazide
- hydromorphone
- hydroxyzine
- hyoscyamine
- idelalisib
- ifosfamide
- iloperidone
- iloprost
- imatinib
- imipramine
- indacaterol
- indapamide
- indinavir
- indocyanine green
- infliximab
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- iobenguane I 123
- iobenguane I 131
- iohexol
- iomeprol
- iopamidol
- ipilimumab
- iptacopan
- irbesartan
- isavuconazonium
- isocarboxazid
- isoetharine
- isoflurane
- isoproterenol
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
- itraconazole
- ivosidenib
- labetalol
- lamotrigine
- landiolol
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- lesinurad
- letermovir
- levalbuterol
- levamlodipine
- levetiracetam
- levobetaxolol ophthalmic
- levobunolol ophthalmic
- levocetirizine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- levothyroxine
- lidocaine
- linagliptin
- lindane topical
- linezolid
- liothyronine
- liraglutide
- lisdexamfetamine
- lisinopril
- lithium
- lixisenatide
- lofexidine
- lonafarnib
- lonapegsomatropin
- loperamide
- lorazepam
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
- ma huang
- maprotiline
- mavacamten
- mavorixafor
- mazindol
- mebrofenin
- mecamylamine
- meclizine
- melatonin
- mepenzolate
- meperidine
- mephentermine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaproterenol
- metaraminol
- metaxalone
- metformin
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methoxamine
- methoxyflurane
- methscopolamine
- methsuximide
- methyclothiazide
- methyldopa
- methylene blue
- methylergonovine
- methylphenidate
- methysergide maleate
- metipranolol ophthalmic
- metoclopramide
- metolazone
- metoprolol
- metreleptin
- metrizamide
- metyrosine
- mibefradil
- miconazole
- midazolam
- midodrine
- mifepristone
- miglitol
- milnacipran
- minoxidil
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- moexipril
- molindone
- morphine
- morphine liposomal
- mosunetuzumab
- nabilone
- nadolol
- nafcillin
- nalbuphine
- naloxone
- naltrexone
- naratriptan
- nateglinide
- nebivolol
- nefazodone
- nelfinavir
- nemolizumab
- nevirapine
- nicardipine
- nifedipine
- nimodipine
- nirogacestat
- nisoldipine
- nitroglycerin
- nitroprusside
- nitrous oxide
- nivolumab
- norepinephrine
- nortriptyline
- olanzapine
- oliceridine
- olmesartan
- olodaterol
- olopatadine nasal
- olutasidenib
- omaveloxolone
- ondansetron
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- oxytocin
- ozanimod
- pacritinib
- paliperidone
- palonosetron
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- pazopanib
- pegvisomant
- pembrolizumab
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phendimetrazine
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentermine
- phentolamine
- phenylbutazone
- phenylpropanolamine
- phenytoin
- pimozide
- pindolol
- pioglitazone
- pirbuterol
- pirtobrutinib
- pitolisant
- polyethylene glycol 3350 with electrolytes
- polythiazide
- posaconazole
- pralsetinib
- pramipexole
- pramlintide
- prasugrel
- prazosin
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pseudoephedrine
- pyrilamine
- racepinephrine
- ramelteon
- ramipril
- ranolazine
- rasagiline
- rauwolfia serpentina
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- repotrectinib
- reserpine
- retifanlimab
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- risperidone
- ritlecitinib
- ritodrine
- ritonavir
- rizatriptan
- ropeginterferon alfa-2b
- ropinirole
- rosiglitazone
- rotigotine
- rufinamide
- safinamide
- salmeterol
- saquinavir
- sarilumab
- satralizumab
- saxagliptin
- scopolamine
- scopolamine ophthalmic
- secobarbital
- secukinumab
- selegiline
- selexipag
- selpercatinib
- semaglutide
- sertraline
- sevoflurane
- sibutramine
- sildenafil
- silodosin
- siltuximab
- sitagliptin
- sodium oxybate
- sodium polystyrene sulfonate
- sofpironium topical
- solifenacin
- solriamfetol
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotagliflozin
- sotalol
- sotorasib
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- sulfinpyrazone
- sumatriptan
- suvorexant
- suzetrigine
- talquetamab
- tamsulosin
- tapentadol
- tarlatamab
- tasimelteon
- tazemetostat
- tebentafusp
- teclistamab
- tecovirimat
- tedizolid
- telaprevir
- telithromycin
- telmisartan
- telotristat
- temazepam
- terazosin
- terbinafine
- terbutaline
- tetrabenazine
- thalidomide
- theophylline
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- thyroid desiccated
- tiagabine
- ticagrelor
- timolol
- timolol ophthalmic
- tirzepatide
- tislelizumab
- tizanidine
- tocilizumab
- tofacitinib
- tolazamide
- tolbutamide
- tolcapone
- tolterodine
- topiramate
- toripalimab
- torsemide
- tovorafenib
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- tremelimumab
- treosulfan
- treprostinil
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trofinetide
- troglitazone
- troleandomycin
- tropicamide ophthalmic
- trospium
- tryptophan
- tucatinib
- vadadustat
- valbenazine
- valerian
- valproic acid
- valsartan
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- vorasidenib
- voriconazole
- vortioxetine
- voxelotor
Guaifenesin/hydrocodone/phenylephrine alcohol/food interactions
There is 1 alcohol/food interaction with guaifenesin / hydrocodone / phenylephrine.
Guaifenesin/hydrocodone/phenylephrine disease interactions
There are 20 disease interactions with guaifenesin / hydrocodone / phenylephrine which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- cardiovascular disease
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
- BPH
- diabetes
- glaucoma
More about guaifenesin / hydrocodone / phenylephrine
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Ozempic
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Robitussin Nighttime Cough DM
Robitussin Nighttime Cough DM is used for cough, cough and nasal congestion
Vicks Nyquil Cough
Vicks Nyquil Cough is used for cough, cough and nasal congestion
Dextromethorphan/guaifenesin/phenylephrine
Dextromethorphan/guaifenesin/phenylephrine systemic is used for cough and nasal congestion
Brompheniramine/dextromethorphan/pseudoephedrine
Brompheniramine/dextromethorphan/pseudoephedrine systemic is used for cough and nasal congestion
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.