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Guaifenesin / Hydrocodone / Phenylephrine Dosage

Medically reviewed on January 22, 2018.

Applies to the following strengths: 50 mg-2.5 mg-7.5 mg/5 mL; 120 mg-2.5 mg-6 mg/5 mL; 150 mg-2.5 mg-6 mg/5 mL; 100 mg-2.5 mg-7.5 mg/5 mL; 100 mg-2 mg-10 mg/5 mL; 100 mg-5 mg-15 mg/5 mL; 100 mg-4 mg-10 mg/5 mL; 100 mg-2.5 mg-5 mg/5 mL; 100 mg-5 mg-7.5 mg/5 mL; 225 mg-2.5 mg-10 mg/5 mL; 200 mg-2.5 mg-7.5 mg/5 mL

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cough and Nasal Congestion

Guaifenesin 100 mg-hydrocodone 2.5 mg-phenylephrine 5 mg/5 mL oral liquid:
10 mL orally every 4 to 6 hours not to exceed 6 doses daily.

Guaifenesin 100 mg-hydrocodone 2.5 mg-phenylephrine 7.5 mg/5 mL oral syrup:
10 mL orally every 4 to 6 hours not to exceed 6 doses daily.

Guaifenesin 100 mg-hydrocodone 4 mg-phenylephrine 10 mg/5 mL oral liquid:
5 mL orally every 4 to 6 hours not to exceed 6 doses daily.

Guaifenesin 120 mg-hydrocodone 2.5 mg-phenylephrine 6 mg/5 mL oral syrup or guaifenesin 200 mg-hydrocodone 2.5 mg-phenylephrine 7.5 mg/5 mL oral liquid:
10 mL orally every 4 to 6 hours not to exceed 4 doses daily.

Guaifenesin 150 mg-hydrocodone 2.5 mg-phenylephrine 6 mg/5 mL oral syrup:
10 mL orally every 4 to 6 hours not to exceed 6 doses daily.

Guaifenesin 225 mg-hydrocodone 2.5 mg-phenylephrine 10 mg/5 mL oral elixir:
10 mL orally every 4 to 6 hours.

Usual Pediatric Dose for Cough and Nasal Congestion

Guaifenesin 100 mg-hydrocodone 2.5 mg-phenylephrine 5 mg/5 mL oral liquid:
2 to 6 years: 2.5 mL orally every 4 to 6 hours not to exceed 6 doses daily.
7 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 6 doses daily.
12 years or older:10 mL orally every 4 to 6 hours not to exceed 6 doses daily.

Guaifenesin 100 mg-hydrocodone 2.5 mg-phenylephrine 7.5 mg/5 mL oral syrup:
2 to 3 years: 0.075 mg/kg of hydrocodone orally 4 times daily.
4 to 6 years: 2.5 mL orally every 4 to 6 hours not to exceed 6 doses daily.
7 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 6 doses daily.
12 years or older: 10 mL orally every 4 to 6 hours not to exceed 6 doses daily.

Guaifenesin 100 mg-hydrocodone 4 mg-phenylephrine 10 mg/5 mL oral liquid:
2 to 5 years: 1.25 mL orally every 4 to 6 hours not to exceed 6 doses daily.
6 to 11 years: 2.5 mL orally every 4 to 6 hours not to exceed 6 doses daily.
12 years or older: 5 mL orally every 4 to 6 hours not to exceed 6 doses daily.

Guaifenesin 120 mg-hydrocodone 2.5 mg-phenylephrine 6 mg/5 mL oral syrup:
6 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 4 doses daily.
12 years or older: 10 mL orally every 4 to 6 hours not to exceed 4 doses daily.

Guaifenesin 150 mg-hydrocodone 2.5 mg-phenylephrine 6 mg/5 mL oral syrup:
2 to 3 years: 0.075 mg/kg of hydrocodone orally 4 times daily.
4 to 6 years: 2.5 mL orally every 4 to 6 hours not to exceed 6 doses daily.
7 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 6 doses daily.
12 years or older: 10 mL orally every 4 to 6 hours not to exceed 6 doses daily.

Guaifenesin 200 mg-hydrocodone 2.5 mg-phenylephrine 7.5 mg/5 mL oral liquid:
2 to 6 years: 2.5 mL orally every 4 to 6 hours not to exceed 10 mL daily.
7 to 11 years: 5 mL orally every 4 to 6 hours not to exceed 20 mL daily.
12 years or older: 10 mL orally every 4 to 6 hours not to exceed 40 mL daily.

Guaifenesin 225 mg-hydrocodone 2.5 mg-phenylephrine 10 mg/5 mL oral elixir:
6 to 11 years: 5 mL orally every 4 to 6 hours.
12 years or older:: 10 mL orally every 4 to 6 hours.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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