Generic name: DOLUTEGRAVIR SODIUM 50mg, ABACAVIR SULFATE 600mg, LAMIVUDINE 300mg
Dosage form: tablet, film coated
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Screening for HLA-B*5701 Allele prior to Starting TRIUMEQ
Screen for the HLA‑B*5701 allele prior to initiating therapy with TRIUMEQ [see Boxed Warning, Warnings and Precautions (5.1)].
TRIUMEQ is a fixed-dose combination product containing 600 mg of abacavir, 50 mg of dolutegravir, and 300 mg of lamivudine. The recommended dosage regimen of TRIUMEQ in adults is one tablet once daily orally with or without food.
Dosage Recommendation with Certain Concomitant Medications
The dolutegravir dose (50 mg) in TRIUMEQ is insufficient when coadministered with medications listed in Table 1 that may decrease dolutegravir concentrations; the following dolutegravir dosage regimen is recommended.
Table 1. Dosing Recommendations for TRIUMEQ with Coadministered Medications
Efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, carbamazepine, or rifampin
The recommended dolutegravir dosage regimen is 50 mg twice daily. An additional dolutegravir 50-mg tablet, separated by 12 hours from TRIUMEQ, should be taken.
Not Recommended Due to Lack of Dosage Adjustment
Because TRIUMEQ is a fixed-dose tablet and cannot be dose adjusted, TRIUMEQ is not recommended in:
- patients with creatinine clearance less than 50 mL per minute [see Use in Specific Populations (8.6)].
- patients with mild hepatic impairment. TRIUMEQ is contraindicated in patients with moderate or severe hepatic impairment [see Contraindications (4), Use in Specific Populations (8.7)].
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