Abacavir, dolutegravir, and lamivudine
Generic Name: abacavir, dolutegravir, and lamivudine (a BAK a vir, DOE loo TEG ra vir, la MIV ue deen)
Brand Name: Triumeq
Medically reviewed on July 20, 2018
What is abacavir, dolutegravir, and lamivudine (Triumeq)?
Abacavir, dolutegravir, and lamivudine are antiviral medications that prevent human immunodeficiency virus (HIV) from multiplying in your body.
Abacavir, dolutegravir, and lamivudine (Triumeq) is a combination medicine used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). abacavir, dolutegravir, and lamivudine is not a cure for HIV or AIDS.
Triumeq is for use in adults and children who weigh at least 88 pounds (40 kilograms).
Triumeq may also be used for purposes not listed in this medication guide.
Stop using this medicine and call your doctor at once if you have any of these signs of an allergic reaction: fever; rash; nausea, vomiting, diarrhea, stomach pain; general ill feeling, extreme tiredness, body aches; shortness of breath, cough, sore throat.
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.
Before taking this medicine
You should not use Triumeq if you are allergic to abacavir, dolutegravir, or lamivudine, or if:
you also take dofetilide (Tikosyn);
you have moderate or severe liver disease;
you have a gene variation called HLA-B*5701 allele (your doctor will test you for this);
Once you have had an allergic reaction to abacavir or dolutegravir, you must never use these medicines again.
Do not take other medicines that contain:
abacavir (Epizicom, Trizivir, Ziagen);
lamivudine (Combivir, Dutrebis, Epivir, Epzicom, Trizivir); or
Triumeq can cause severe or life-threatening effects on your liver, especially if you have hepatitis C.
Tell your doctor if you have ever had:
liver disease (especially hepatitis B or C);
if you drink alcohol.
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you've taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.
Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
How should I take Triumeq?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Triumeq comes with a Medication Guide and a Warning Card listing symptoms of an allergic reaction. Read this information and learn what symptoms to watch for. Keep the Wallet Card with you at all times.
Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.
Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.
If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using Triumeq. You may need frequent liver function tests while using abacavir, dolutegravir, and lamivudine and for several months after your last dose.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 4 hours. Do not use two doses at one time.
Get your prescription refilled before you run out of medicine completely.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Triumeq?
Avoid eating or drinking anything that contains sorbitol (an artificial sweetener).
Using abacavir, dolutegravir, and lamivudine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Triumeq side effects
Stop using Triumeq and call your doctor at once if you have symptoms of an allergic reaction from two or more of these specific side effect groups:
Group 1 - fever;
Group 2 - rash;
Group 3 - nausea, vomiting, diarrhea, stomach pain;
Group 4 - general ill feeling, extreme tiredness, body aches;
Group 5 - shortness of breath, cough, sore throat.
Once you have had an allergic reaction to a medicine that contains abacavir or dolutegravir, you must never use it again. If you stop taking Triumeq for any reason, talk to your doctor before you start taking it again.
Call your doctor at once if you have:
lactic acidosis--unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired;
liver problems--swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.
Triumeq affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:
trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.
Common side effects may include:
changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Abacavir, dolutegravir, and lamivudine dosing information
Usual Adult Dose for HIV Infection:
1 tablet orally once a day
Use: For the treatment of HIV-1 infection
Usual Pediatric Dose for HIV Infection:
At least 40 kg: 1 tablet orally once a day
Use: For the treatment of HIV-1 infection
What other drugs will affect Triumeq?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Some medicines can make Triumeq much less effective when taken at the same time. If you take any of the following medicines, take your Triumeq dose 2 hours before or 6 hours after you take the other medicine.
vitamin or mineral supplements that contain calcium or iron.
Tell your doctor about all your other medicines, especially:
any other medicine to treat HIV or AIDS;
medicine to treat hepatitis--interferon, ribavirin.
This list is not complete and many other drugs may affect Triumeq. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 3.01.
More about abacavir/dolutegravir/lamivudine
- Abacavir/dolutegravir/lamivudine Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 97 Reviews
- Drug class: antiviral combinations
Other brands: Triumeq