Abacavir, dolutegravir, and lamivudine
Generic name: abacavir, dolutegravir, and lamivudine (a BAK a vir, DOE loo TEG ra vir, la MIV ue deen)
Brand name: Triumeq
Dosage forms: oral tablet (600 mg-50 mg-300 mg)
Drug class: Antiviral combinations
What is abacavir, dolutegravir, and lamivudine (Triumeq)?
Abacavir, dolutegravir, and lamivudine (Triumeq) is a combination medicine used to treat human immunodeficiency virus (HIV), the virus that can cause acquired immunodeficiency syndrome (AIDS). abacavir, dolutegravir, and lamivudine is not a cure for HIV or AIDS.
Triumeq is for use in adults and children who weigh at least 88 pounds (40 kilograms).
Triumeq may also be used for purposes not listed in this medication guide.
You should not take this medicine if you have ever had an allergic reaction to any medicine that contains abacavir, or if you have a gene variation called HLA-B*5701 allele. Also, you should not use this medicine if you have moderate or severe liver disease, or if you are also taking dofetilide (Tikosyn).
Stop using this medicine and call your doctor at once if you have any of these signs of an allergic reaction: fever; rash; nausea, vomiting, diarrhea, stomach pain; general ill feeling, extreme tiredness, body aches; shortness of breath, cough, sore throat.
If you've ever had hepatitis B, it may become active or get worse after you stop using this medicine. You may need frequent liver function tests for several months.
Before taking this medicine
You should not use Triumeq if you are allergic to abacavir, dolutegravir, or lamivudine, or if:
you also take dofetilide (Tikosyn);
you have moderate or severe liver disease;
you have a gene variation called HLA-B*5701 allele (your doctor will test you for this); or
Tell your doctor if you have ever had:
liver disease (especially hepatitis B or C);
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you are overweight, or if you are a woman. Ask your doctor about your risk.
You may need to have a negative pregnancy test before starting this treatment.
Triumeq may harm an unborn baby if you take the medicine at the time of conception or during the first 12 weeks of pregnancy. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.
If you are pregnant, use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
How should I take Triumeq?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
You may take Triumeq with or without food.
Triumeq comes with a Medication Guide and a Warning Card listing symptoms of an allergic reaction. Read this information and learn what symptoms to watch for. Keep the Wallet Card with you at all times.
You may need to take an extra daily dose of dolutegravir (Tivicay) if you take Triumeq with certain other medicines.
Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or stop using a medicine without your doctor's advice. Every person with HIV should remain under the care of a doctor.
Store at room temperature away from moisture and heat. Keep the tablets in their original container, along with the packet or canister of moisture-absorbing preservative.
If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using Triumeq. You may need frequent liver function tests while using abacavir, dolutegravir, and lamivudine and for several months after your last dose.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Get your prescription refilled before you run out of medicine completely. If you miss several doses, you may have a dangerous or even fatal allergic reaction once you start taking this medication again.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Triumeq?
Using abacavir, dolutegravir, and lamivudine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Triumeq side effects
Call your doctor at once if you have symptoms of an allergic reaction from two or more of these specific side effect groups:
Group 1 - fever;
Group 2 - rash;
Group 3 - nausea, vomiting, diarrhea, stomach pain;
Group 4 - general ill feeling, extreme tiredness, body aches;
Group 5 - shortness of breath, cough, sore throat.
Once you have had an allergic reaction to a medicine that contains abacavir or dolutegravir, you must never use it again. If you stop taking Triumeq for any reason, talk to your doctor before you start taking it again.
Call your doctor at once if you have:
other signs of allergic reaction--skin blisters or peeling, eye redness, swelling in your face or throat, trouble breathing;
liver problems--swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Triumeq affects your immune system, which may cause certain side effects (even weeks or months after you've taken this medicine). Tell your doctor if you have:
trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or
swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Abacavir, dolutegravir, and lamivudine dosing information
Usual Adult Dose for HIV Infection:
1 tablet orally once a day
Use: For the treatment of HIV-1 infection
Usual Pediatric Dose for HIV Infection:
At least 40 kg: 1 tablet orally once a day
Use: For the treatment of HIV-1 infection
What other drugs will affect Triumeq?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Some medicines can make Triumeq much less effective when taken at the same time. If you take any of the following medicines, take your Triumeq dose 2 hours before or 6 hours after you take the other medicine.
buffered medicine; or
vitamin or mineral supplements that contain calcium or iron (can be taken at the same time with Triumeq if you take with food).
Many drugs can affect Triumeq. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Frequently asked questions
More about abacavir / dolutegravir / lamivudine
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
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- Drug class: antiviral combinations
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Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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