Generic name: RITONAVIR 50mg, OMBITASVIR HEMINONAHYDRATE 12.5mg, PARITAPREVIR DIHYDRATE 75mg
Dosage form: tablets
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Testing Prior to Initiation of TECHNIVIE
Recommended Dosage in Adults
The recommended dosage of TECHNIVIE is two tablets taken orally once daily (in the morning). Take TECHNIVIE with a meal without regard to fat or calorie content [see Clinical Pharmacology (12.3)].
TECHNIVIE is used in combination with ribavirin (RBV). When administered with TECHNIVIE, the recommended dosage of RBV is based on weight: 1000 mg per day for subjects less than 75 kg and 1200 mg per day for those weighing at least 75 kg, divided and administered twice-daily with food. For ribavirin dosage modifications, refer to the ribavirin prescribing information.
Table 1 shows the recommended TECHNIVIE treatment regimen and duration for HCV genotype 4 patients without cirrhosis.
|Genotype 4 without cirrhosis||TECHNIVIE + ribavirin*||12 weeks|
|*TECHNIVIE administered without RBV for 12 weeks may be considered for treatment-naïve patients who cannot take or tolerate ribavirin [see Microbiology (12.4) and Clinical Studies (14)].|