Polymyxin B/Trimethoprim Ophthalmic Dosage

Medically reviewed by Drugs.com. Last updated on Jan 24, 2025.

Usual Adult Dose for Bacterial Conjunctivitis

Instill 1 drop in the affected eye(s) every 3 hours for 7 to 10 days.
Maximum dose: 6 doses/day

Uses: For the treatment of mild to moderate surface ocular bacterial infections (including acute bacterial conjunctivitis) and blepharoconjunctivitis due to susceptible strains of Staphylococcus aureus, S epidermidis, Streptococcus pneumoniae, viridans streptococci, Haemophilus influenzae, Pseudomonas aeruginosa

Usual Adult Dose for Blepharoconjunctivitis

Instill 1 drop in the affected eye(s) every 3 hours for 7 to 10 days.
Maximum dose: 6 doses/day

Uses: For the treatment of mild to moderate surface ocular bacterial infections (including acute bacterial conjunctivitis) and blepharoconjunctivitis due to susceptible strains of Staphylococcus aureus, S epidermidis, Streptococcus pneumoniae, viridans streptococci, Haemophilus influenzae, Pseudomonas aeruginosa

Usual Pediatric Dose for Bacterial Conjunctivitis

2 months or older: Instill 1 drop in the affected eye(s) every 3 hours for 7 to 10 days.
Maximum dose: 6 doses/day

Uses: For the treatment of mild to moderate surface ocular bacterial infections (including acute bacterial conjunctivitis) and blepharoconjunctivitis due to susceptible strains of S aureus, S epidermidis, S pneumoniae, viridans streptococci, H influenzae, P aeruginosa

Usual Pediatric Dose for Blepharoconjunctivitis

2 months or older: Instill 1 drop in the affected eye(s) every 3 hours for 7 to 10 days.
Maximum dose: 6 doses/day

Uses: For the treatment of mild to moderate surface ocular bacterial infections (including acute bacterial conjunctivitis) and blepharoconjunctivitis due to susceptible strains of S aureus, S epidermidis, S pneumoniae, viridans streptococci, H influenzae, P aeruginosa

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
Known hypersensitivity to either active component or to any of the ingredients

Safety and efficacy have not been established in patients younger than 2 months.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Not for injection into the eye

• Store at 15C to 25C (59F to 77F); protect from light.

• Avoid contaminating the applicator tip with material from the eye, fingers, or any other source.
• Discontinue use and contact physician if redness, irritation, swelling, or pain persists/worsens.
• Do not wear contact lenses if you have signs/symptoms of ocular bacterial infections.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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