Skip to Content

Polymyxin b / trimethoprim ophthalmic Side Effects

For the Consumer

Applies to polymyxin b / trimethoprim ophthalmic: eye solution

No COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur while taking polymyxin b / trimethoprim ophthalmic:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); eyelid swelling; increased or persistent redness, irritation, swelling, pain, or tearing of the eye.

For Healthcare Professionals

Applies to polymyxin b / trimethoprim ophthalmic: ophthalmic solution


Ocular side effects are the most common, and include local irritation, increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use.[Ref]


Hypersensitivity reactions have included lid edema, itching, increased redness, tearing, and/or circumocular rash.[Ref]


Dermatologic side effects associated with oral trimethoprim have included photosensitivity.[Ref]


1. "Product Information. Polytrim (polymyxin B-trimethoprim ophthalmic)." Allergan Inc, Irvine, CA.

It is possible that some side effects of polymyxin b / trimethoprim ophthalmic may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.