Istradefylline Dosage

Medically reviewed by Drugs.com. Last updated on Oct 7, 2024.

Usual Adult Dose for Parkinson's Disease

Initial dose: 20 mg orally once a day

• Dose may be increased based on individual need and tolerability

Maintenance dose: 20 to 40 mg orally once a day
Maximum dose: 40 mg/day

Use: As adjunctive treatment to levodopa/carbidopa in patients with Parkinson's disease experiencing OFF episodes.

Renal Dose Adjustments

CrCl 15 to 89 mL/min: No adjustment recommended
CrCl less than 15 mL/min: Data not available

Liver Dose Adjustments

Mild hepatic impairment (Child-Pugh A): No adjustment recommended
Moderate hepatic impairment (Child-Pugh B): Maximum dose: 20 mg orally once a day
Severe hepatic impairment (Child-Pugh C): Avoid use

Dose Adjustments

Concomitant Use with Strong CYP450 3A4 Inhibitors:

• Maximum istradefyilline dose: 20 mg orally once a day

Concomitant Use with Strong CYP450 3A4 Inhibitors:

• Avoid istradefyilline use

Tobacco Use:

• For patients who smoke 20 or more cigarettes per day (or equivalent of another tobacco product): 40 mg orally once a day

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Take orally once a day with or without food

General:

• This drug should be taken with levodopa/carbidopa.

Monitoring:

• Monitor for increased dyskinesias
• Monitor for hallucinations/psychotic behavior
• Question patients on intense urges

Patient advice:

• Patients should be instructed to read the US FDA-approved patient labeling (Patient Information).
• Patients should understand that this drug may cause dyskinesia, exacerbate preexisting dyskinesia, cause intense urges, and/or cause hallucinations or psychotic behavior; if any of these behaviors occur, they should be instructed to report them to their healthcare provider.
• Patients should understand that this drug may interact with other drugs including over-the-counter drugs, dietary supplements, and herbal products; they should be instructed to inform their health care provider of all medications they are taking, plan to take, or will stop taking.
• Patients should understand that tobacco products may cause this drug to be less effective and a higher dose may be needed if they smoke 20 or more cigarettes a day.
• Women of childbearing potential should be advised to use contraception during treatment.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer