Istradefylline Dosage
Medically reviewed by Drugs.com. Last updated on Oct 5, 2021.
Applies to the following strengths: 20 mg; 40 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Parkinson's Disease
Initial dose: 20 mg orally once a day
-Dose may be increased based on individual need and tolerability
Maintenance dose: 20 to 40 mg orally once a day
Maximum dose: 40 mg/day
Use: As adjunctive treatment to levodopa/carbidopa in patients with Parkinson's disease experiencing OFF episodes.
Renal Dose Adjustments
CrCl 15 to 89 mL/min: No adjustment recommended
CrCl less than 15 mL/min: Data not available
Liver Dose Adjustments
Mild hepatic impairment (Child-Pugh A): No adjustment recommended
Moderate hepatic impairment (Child-Pugh B): Maximum dose: 20 mg orally once a day
Severe hepatic impairment (Child-Pugh C): Avoid use
Dose Adjustments
Concomitant Use with Strong CYP450 3A4 Inhibitors:
-Maximum istradefyilline dose: 20 mg orally once a day
Concomitant Use with Strong CYP450 3A4 Inhibitors:
-Avoid istradefyilline use
Tobacco Use:
-For patients who smoke 20 or more cigarettes per day (or equivalent of another tobacco product): 40 mg orally once a day
Precautions
CONTRAINDICATIONS: None
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
-Take orally once a day with or without food
General:
-This drug should be taken with levodopa/carbidopa.
Monitoring:
-Monitor for increased dyskinesias
-Monitor for hallucinations/psychotic behavior
-Question patients on intense urges
Patient advice:
-Patients should be instructed to read the US FDA-approved patient labeling (Patient Information).
-Patients should understand that this drug may cause dyskinesia, exacerbate preexisting dyskinesia, cause intense urges, and/or cause hallucinations or psychotic behavior; if any of these behaviors occur, they should be instructed to report them to their healthcare provider.
-Patients should understand that this drug may interact with other drugs including over-the-counter drugs, dietary supplements, and herbal products; they should be instructed to inform their health care provider of all medications they are taking, plan to take, or will stop taking.
-Patients should understand that tobacco products may cause this drug to be less effective and a higher dose may be needed if they smoke 20 or more cigarettes a day.
-Women of childbearing potential should be advised to use contraception during treatment.
More about istradefylline
- Side effects
- Drug interactions
- During pregnancy
- Reviews (1)
- En español
- Drug class: miscellaneous antiparkinson agents
Patient resources
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Professional resources
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.