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Guaifenesin / Phenylephrine Dosage

Medically reviewed on January 26, 2017.

Applies to the following strengths: 100 mg-5 mg/5 mL; 200 mg-25 mg; 50 mg-2.5 mg/5 mL; 300 mg-20 mg; 600 mg-30 mg; 20 mg-1.5 mg/mL; 900 mg-25 mg; 400 mg-10 mg; 100 mg-7.5 mg/5 mL; 600 mg-40 mg; 600 mg-20 mg; 1200 mg-40 mg; 375 mg-20 mg; 275 mg-25 mg; 1200 mg-30 mg; 900 mg-30 mg; 1200 mg-25 mg; 600 mg-15 mg; 200 mg-40 mg; 600 mg-25 mg; 1000 mg-30 mg; 650 mg-23.75 mg; 835 mg-30 mg; 200 mg-7.5 mg/5 mL; 600 mg-12.5 mg; 395 mg-10 mg; 380 mg-10 mg; 200 mg-5 mg; 390 mg-10 mg; 385 mg-10 mg; 600 mg-10 mg; 400 mg-15 mg; 300 mg-10 mg; 400 mg-30 mg; 800 mg-25 mg; 200 mg-5 mg/5 mL; 50 mg-2.5 mg/mL; 100 mg-2.5 mg/5 mL; 800 mg-40 mg; 200 mg-7.5 mg; 388 mg-10 mg; 650 mg-25 mg; 800 mg-20 mg; 835 mg-25 mg; 1100 mg-30 mg; 600 mg-18 mg; 650 mg-40 mg; 315 mg-20 mg; 1200 mg-35 mg; 800 mg-30 mg; 1000 mg-40 mg; 100 mg-10 mg/5 mL; 75 mg-7.5 mg/5 mL; 1200 mg-20 mg; 550 mg-8.5 mg; 1050 mg-30 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cough and Nasal Congestion

Tablets:
Guaifenesin 550 mg- phenylephrine 8.5 mg: 1 tablet orally every 6 to 8 hours, not to exceed 4 tablets a day.
Guaifenesin 380 mg- phenylephrine 10 mg: 1 tablet orally every 4 hours, not to exceed 6 tablets a day.
Guaifenesin 388 mg- phenylephrine 10 mg: 1 tablet orally every 4 hours, not to exceed 6 tablets a day.
Guaifenesin 200 mg- phenylephrine 5 mg: 2 tablets orally every 4 hours, not to exceed 12 tablets a day.

Liquid:
Guaifenesin 75 mg- phenylephrine 7.5 mg/5 mL: 10 mL orally every 4 to 6 hours, up to 40 mL a day.
Guaifenesin 100 mg- phenylephrine 5 mg/5 mL or guaifenesin 200 mg- phenylephrine 7.5 mg/5 mL: 10 mL orally every 4 to 6 hours, up to 40 mL a day.
Guaifenesin 100 mg- phenylephrine 7.5 mg/5 mL: 5 to 10 mL orally every 4 to 6 hours, up to 40 mL a day.
Guaifenesin 200 mg- phenylephrine 5 mg/5 mL: 5 to 10 mL orally every 4 to 6 hours, up to 60 mL a day.
Guaifenesin 100 mg- phenylephrine 10 mg/5 mL: 5 mL orally every 4 to 6 hours, up to 40 mL a day.

Tablets, extended-release:
Guaifenesin 275 mg- phenylephrine 25 mg: 1 to 2 tablets orally every 12 hours, up to 4 tablets a day.
Guaifenesin 600 mg- phenylephrine 18 mg, or guaifenesin 300 mg- phenylephrine 20 mg, or guaifenesin 600 mg- phenylephrine 15 mg, or guaifenesin 315 mg- phenylephrine 20 mg: 2 tablets orally every 12 hours.
Guaifenesin 600 mg- phenylephrine 10 mg or guaifenesin 600 mg- phenylephrine 25 mg: 1 to 2 tablets orally every 12 hours.
Guaifenesin 600 mg- phenylephrine 20 mg: 1 to 2 tablets orally every 12 hours, up to 2 tablets a day.
Guaifenesin 600 mg- phenylephrine 30 mg, or guaifenesin 600 mg- phenylephrine 40 mg, or guaifenesin 650 mg- phenylephrine 40 mg: 1 tablet orally every 12 hours.
Guaifenesin 650 mg- phenylephrine 23.75 mg, or guaifenesin 650 mg- phenylephrine 25 mg: 1 tablet orally every 12 hours not to exceed 2 tablets a day.
Guaifenesin 800 mg- phenylephrine 20 mg: 1 tablet orally every 8 hours not to exceed 3 tablets a day.
Guaifenesin 800 mg- phenylephrine 30 mg, or guaifenesin 800 mg- phenylephrine 40 mg, or guaifenesin 835 mg- phenylephrine 25 mg, or guaifenesin 835 mg- phenylephrine 30 mg or guaifenesin 900 mg- phenylephrine 25 mg, or guaifenesin 900 mg- phenylephrine 30 mg, or guaifenesin 1000 mg- phenylephrine 30 mg, or guaifenesin 1000 mg- phenylephrine 40 mg, or guaifenesin 1050 mg- phenylephrine 30 mg, or guaifenesin 1200 mg- phenylephrine 25 mg, or guaifenesin 1100 mg- phenylephrine 30 mg, or guaifenesin 1200 mg- phenylephrine 20 mg, or guaifenesin 1200 mg- phenylephrine 30 mg, or guaifenesin 1200 mg- phenylephrine 35 mg: 1 tablet orally every 12 hours not to exceed 2 tablets a day.
Guaifenesin 600 mg- phenylephrine 12.5 mg: 1 to 2 tablets orally every 12 hours or 1 tablet every 8 hours not to exceed 4 tablets a day.

Capsule, extended-release:
Guaifenesin 200 mg- phenylephrine 7.5 mg, or guaifenesin 300 mg- phenylephrine 10 mg: 1 to 2 capsules orally every 12 hours.
Guaifenesin 375 mg- phenylephrine 20 mg: 1 to 2 capsules orally every 12 hours, up to 3 capsules a day.
Guaifenesin 400 mg- phenylephrine 15 mg: 1 capsule orally every 12 hours.

Usual Pediatric Dose for Cough and Nasal Congestion

guaifenesin-phenylephrine 20 mg- 1.5 mg/ mL:
2 years to 5 years: 1 mL orally every 4 to 6 hours as needed. Do not exceed 4 doses in 24 hours.
6 years to 12 years: 2 mL orally every 4 to 6 hours as needed. Do not exceed 4 doses in 24 hours.

guaifenesin 100 mg- phenylephrine 5 mg/5 mL or guaifenesin 200 mg- phenylephrine 7.5 mg/5 mL or guaifenesin 75 mg - phenylephrine 7.5 mg/5 mL:
2 years to 6 years: 2.5 mL orally every 4 to 6 hours, up to 4 doses/day.
6 years to 11 years: 5 mL orally every 4 to 6 hours, up to 4 doses/day.

guaifenesin 50 mg- phenylephrine 2.5 mg/5 mL or guaifenesin 100 mg- phenylephrine 2.5 mg/5 mL:
2 years to 5 years: 5 mL orally every 4 hours, up to 6 doses a day.
6 years to 11 years: 10 mL orally every 4 hours, up to 6 doses a day.

guaifenesin 200 mg- phenylephrine 5 mg/5 mL:
2 years to 5 years: 2.5 mL orally every 4 hours, up to 6 doses a day.
6 years to 11 years: 5 mL orally every 4 hours, up to 6 doses a day.

Guaifenesin 100 mg- phenylephrine 10 mg/5 mL:
2 years to 5 years: 1.25 mL orally every 4 to 6 hours, up to 8 doses a day.
6 years to 11 years: 2.5 mL orally every 4 to 6 hours, up to 8 doses a day.

6 years to 11 years:
Guaifenesin 550 mg- phenylephrine 8.5 mg: 1/2 tablet orally every 6 to 8 hours, not to exceed 2 tablets a day.

Tablets, extended-release:
Guaifenesin 600 mg- phenylephrine 10 mg or guaifenesin 600 mg- phenylephrine 25 mg: 1/2 to 1 tablet orally every 12 hours.
Guaifenesin 600 mg- phenylephrine 18 mg or guaifenesin 600 mg- phenylephrine 15 mg: 2 tablets orally every 12 hours.
Guaifenesin 650 mg- phenylephrine 40 mg: 1/2 tablet orally every 12 hours.
Guaifenesin 800 mg- phenylephrine 20 mg: 1/2 tablet orally every 8 hours not to exceed 1.5 tablets a day.
Guaifenesin 900 mg- phenylephrine 30 mg, or guaifenesin 650 mg- phenylephrine 23.75 mg: 1/2 tablet orally every 12 hours not to exceed 2 tablets a day.
Guaifenesin 800 mg- phenylephrine 40 mg, or guaifenesin 315 mg- phenylephrine 15 mg: 1 tablet orally every 12 hours not to exceed 2 tablets a day.
Guaifenesin 800 mg- phenylephrine 30 mg, or guaifenesin 650 mg- phenylephrine 25 mg, or guaifenesin 835 mg- phenylephrine 25 mg, or guaifenesin 835 mg- phenylephrine 30 mg, or guaifenesin 900 mg- phenylephrine 25 mg, or guaifenesin 1000 mg - phenylephrine 30 mg, or guaifenesin 1000 mg- phenylephrine 40 mg, or guaifenesin 1050 mg- phenylephrine 30 mg, or guaifenesin 1100 mg- phenylephrine 30 mg, guaifenesin 1200 mg- phenylephrine 20 mg, or guaifenesin 1200 mg- phenylephrine 30 mg: 1/2 tablet orally every 12 hours not to exceed 1 tablet a day.

12 yrs and older:
Guaifenesin 100 mg- phenylephrine 5 mg/5 mL: 10 mL orally every 4 to 6 hours, up to 4 doses a day.
Guaifenesin 550 mg- phenylephrine 8.5 mg: 1 tablet orally every 6 to 8 hours, not to exceed 4 tablets a day.
Guaifenesin 380 mg- phenylephrine 10 mg: 1 tablet orally every 4 hours, not to exceed 6 tablets a day.
Guaifenesin 200 mg- phenylephrine 5 mg: 2 tablets orally every 4 hours, not to exceed 12 tablets a day.
Guaifenesin 100 mg- phenylephrine 10 mg/5 mL: 5 mL orally every 4 to 6 hours, up to 8 doses a day.

Tablets, extended-release:
Guaifenesin 800 mg- phenylephrine 20 mg: 1 tablet every 8 hours not to exceed 3 tablets a day.
Guaifenesin 275 mg- phenylephrine 25 mg or guaifenesin 600 mg- phenylephrine 15 mg: 1 tablet orally every 12 hours.
Guaifenesin 600 mg- phenylephrine 10 mg or guaifenesin 600 mg- phenylephrine 25 mg: 1 to 2 tablets orally every 12 hours.
Guaifenesin 600 mg- phenylephrine 18 mg, or guaifenesin 315 mg- phenylephrine 20 mg: 2 tablets orally every 12 hours.
Guaifenesin 600 mg- phenylephrine 40 mg: 1 tablet orally every 12 hours.
Guaifenesin 650 mg- phenylephrine 23.75 mg, or guaifenesin 650 mg- phenylephrine 25 mg, or guaifenesin 800 mg- phenylephrine 30 mg, or guaifenesin 800 mg- phenylephrine 40 mg, or guaifenesin 835 mg- phenylephrine 25 mg, or guaifenesin 835 mg- phenylephrine 30 mg, or guaifenesin 900 mg- phenylephrine 25 mg, or guaifenesin 900 mg- phenylephrine 30 mg, or guaifenesin 1000 mg- phenylephrine 40 mg, or guaifenesin 1050 mg- phenylephrine 30 mg, or guaifenesin 1100 mg- phenylephrine 30 mg, or guaifenesin 1200 mg- phenylephrine 20 mg, or guaifenesin 1200 mg- phenylephrine 25 mg, or guaifenesin 1200 mg- phenylephrine 30 mg, or guaifenesin 1200 mg- phenylephrine 35 mg: 1 tablet orally every 12 hours not to exceed 2 tablets a day.
Guaifenesin 600 mg- phenylephrine 12.5 mg: 1 to 2 tablets orally every 12 hours or 1 tablet every 8 hours not to exceed 4 tablets a day.

Capsules, extended-release:
Guaifenesin 200 mg- phenylephrine 7.5 mg: 1 to 2 capsules orally every 12 hours.
Guaifenesin 300 mg- phenylephrine 10 mg or Guaifenesin 400 mg - phenylephrine 15 mg: 1 capsule orally every 12 hours.
Guaifenesin 375 mg- phenylephrine 20 mg: 1 to 2 capsules orally every 12 hours, up to 3 a day.

Guaifenesin 388 mg- phenylephrine 10 mg oral tablets:
12 years and over: 1 tablet orally every 4 hours, not to exceed 6 tablets a day.
6 years to 12 years: 1/2 tablet orally every 4 hours, not to exceed 3 tablets a day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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