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Doxycycline Topical Dosage

Applies to the following strengths: 10%

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Periodontitis

The final blended product is 500 mg of formulation containing 50 mg of doxycycline hyclate (doxycycline hyclate, 10%). This is placed into the periodontal pocket. Doxycycline topical is a variable dose product dependent on the size, shape, and number of pockets being treated. Application may be repeated four months after initial treatment.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


Data not available

Other Comments

Preparation for Use:
If refrigerated, remove the pouched product from refrigeration at least 15 minutes prior to mixing. Couple Syringe A (liquid delivery system) and Syringe B (drug powder). Inject the liquid contents of Syringe A (indicated by red stripe) into Syringe B (doxycycline power) and then push the contents back into Syringe A. This entire operation is one mixing cycle. Complete 100 mixing cycles at a pace of one cycle per second using brisk strokes. The contents will be in Syringe A (indicated by red stripe). Hold the coupled syringes vertically with Syringe A at the bottom. Pull back on the Syringe A plunger and allow the contents to flow down the barrel for several seconds. Uncouple the two syringes and attach one of the provided cannulae to Syringe A.

Keeping the cannula tip near the base of the pocket, express the product into the pocket until the formulation reaches the top of the gingival margin. Withdraw the cannula tip from the pocket. In order to separate the tip from the formulation, turn the tip of the cannula towards the tooth, press the tip against the tooth surface, and pinch the string of formulation from the tip of the cannula. Cover the pockets either a periodontal dressing or a cyanoacrylate dental adhesive.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.