Bronchitol Dosage
Generic name: MANNITOL 40mg
Dosage form: capsule
Medically reviewed by Drugs.com. Last updated on Sep 3, 2024.
2.1 Required Testing and Evaluation Prior to Prescribing BRONCHITOL (BRONCHITOL Tolerance Test)
Prior to prescribing BRONCHITOL for treatment of cystic fibrosis, the BRONCHITOL Tolerance Test (BTT) must be administered and performed under the supervision of a healthcare practitioner who is able to manage acute bronchospasm, to identify patients who are suitable candidates for BRONCHITOL maintenance therapy.
- Perform BTT to identify patients who experience bronchospasm, a decrease in FEV1, or a decrease in oxygen saturation with administration of BRONCHITOL. If a patient experiences any of these events during the BTT, the patient has failed the BTT. Do not prescribe BRONCHITOL. If a patient does not experience any of these events during BTT, the patient has passed the BTT and is a candidate for BRONCHITOL therapy.
- Ensure that rescue medication and resuscitation equipment are available for immediate use during the BTT.
- Do not perform the BTT if the patient is considered clinically unstable.
See the BTT Healthcare Practitioner (HCP) Instructions for Use (IFU) for complete instructions and to avoid medication errors
associated with BTT dosing and procedures.
Do not use BRONCHITOL add-on maintenance therapy in patients who fail the BTT.
2.2 Recommended Dosage for Treatment of Cystic Fibrosis
For patients who have passed the BTT, the recommended dosage of BRONCHITOL is 400 mg twice a day by oral inhalation (the contents of 10 capsules administered individually) via the inhaler.
A short-acting bronchodilator should be administered by oral inhalation, 5-15 minutes before every dose of BRONCHITOL.
BRONCHITOL should be taken once in the morning and once in the evening, with the later dose taken at least 2-3 hours before
bedtime.
2.3 Use and Maintenance of Inhaler
Instruct patients on safe hygiene practices (clean and dry hands thoroughly) and correct inhaler use, including loading of capsules and proper inhalation technique per the Patient Instructions for Use.
The BRONCHITOL inhaler should be discarded and replaced after 7 days of use. If the inhaler does need to be washed, the patient should allow the inhaler to thoroughly air dry before next use.
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