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Antihemophilic Factor Dosage

Applies to the following strength(s): recombinant ; human ; recombinant albumin-free ; recombinant PEGylated ; porcine ; recombinant fc fusion protein

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Hemophilia A

Although dosage must be individualized according to the needs of the patient (weight, severity of hemorrhage, presence of inhibitors), the following general dosages are suggested:
Number of AHF I.U. required = (body weight (in kg) x desired Factor VIII increase (% normal)) x 0.5

Dosage necessary to maintain the therapeutic plasma level bases on bleeding episode:

Minor hemorrhage (superficial, early hemorrhages, hemorrhages into joints): Therapeutically necessary plasma level of FVIII activity is 20% to 40% of normal, repeated every 12 to 24 hours as necessary until resolved. (At least 1 day, depending upon the severity of the bleeding episode.)
Moderate (bleeding into muscles, mild head trauma, bleeding into the oral cavity): Therapeutically necessary plasma level of FVIII activity is 30% to 60% of normal, repeated every 12 to 24 hours for 3-4 days or until adequate local hemostasis is achieved.
Major (gastrointestinal bleeding, intracranial, intraabdominal or intrathoracic bleeding, fractures): Therapeutically necessary plasma level of FVIII activity is 60% to 100 % of normal, repeated every 8 to 24 hours until bleeding is resolved, resolved, or in the case of surgery, until adequate local hemostasis and wound healing are achieved.

Usual Pediatric Dose for Hemophilia A

Routine prophylaxis to prevent or reduce the frequency of bleeding episodes:
Up to 16 years of age: 20 to 40 IU per kg every other day (3 to 4 times weekly). Alternatively, an every third day dosing regimen targeted to maintain Factor VIII trough levels greater than 1% may be employed.

Dosage necessary to maintain the therapeutic plasma level based on an active bleeding episode:
Although dosage must be individualized according to the needs of the patient (weight, severity of hemorrhage, presence of inhibitors), the following general dosages are suggested: Number of Antihemophilic Factor IU required = (body weight (in kg) x desired Factor VIII increase (% normal)) x 0.5
or
Minor hemorrhage (superficial, early hemorrhages, hemorrhages into joints): Therapeutically necessary plasma level of Factor VIII activity is 20% to 40% of normal, repeated every 12 to 24 hours as necessary until resolved. (At least 1 day, depending upon the severity of the bleeding episode.)
Moderate (bleeding into muscles, mild head trauma, bleeding into the oral cavity): Therapeutically necessary plasma level of Antihemophilic Factor VIII activity is 30% to 60% of normal, repeated every 12 to 24 hours for 3-4 days or until adequate local hemostasis is achieved.
Major (gastrointestinal bleeding, intracranial, intra abdominal or intrathoracic bleeding, fractures): Therapeutically necessary plasma level of Antihemophilic Factor VIII activity is 60% to 100 % of normal, repeated every 8 to 24 hours until bleeding is resolved, resolved, or in the case of surgery, until adequate local hemostasis and wound healing are achieved.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

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