Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine Dosage

Medically reviewed by Drugs.com. Last updated on Aug 16, 2023.

Applies to the following strengths: 650 mg-20 mg-12.5 mg-10 mg/30 mL; 325 mg-10 mg-6.25 mg-5 mg/15 mL; 325 mg-10 mg-6.25 mg-5 mg; 250 mg-10 mg-6.25 mg-5 mg; 650 mg-20 mg-12.5 mg-10 mg; varying strength

Usual Adult Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ doxylamine 6.25 mg/ phenylephrine 5 mg per unit (tablet/capsule/liquid-filled capsule): 2 orally every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per packet: 1 packet every 4 hours
Maximum dose: 5 packets per 24 hours

Usual Pediatric Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ doxylamine 6.25 mg/ phenylephrine 5 mg per unit (tablet/capsule/liquid-filled capsule):
12 years and older: 2 orally every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per packet:
12 years and older: 1 packet every 4 hours
Maximum dose: 5 packets per 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution.

Precautions

CONTRAINDICATIONS:

Current use of any other drug containing acetaminophen.
Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Patient advice:

Take only as directed.
This product contains acetaminophen; severe liver damage may occur with use of more than directed, use with other acetaminophen-containing medications, or having 3 or more alcoholic drinks a day during use.
Do not use with any other drug containing acetaminophen.
Avoid drinking alcohol while on this drug.
If sore throat is severe, lasts over 2 days, or is accompanied by fever, headache, rash, nausea, or vomiting, seek medical attention.
If cough comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
Discontinue for cough, pain, or nasal congestion that worsens or lasts over 7 days, if new symptoms arise, fever worsens or lasts over 3 days, or for redness or swelling.