Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine Dosage
Medically reviewed by Drugs.com. Last updated on May 2, 2025.
Applies to the following strengths: 650 mg-20 mg-12.5 mg-10 mg/30 mL; 325 mg-10 mg-6.25 mg-5 mg/15 mL; 325 mg-10 mg-6.25 mg-5 mg; 250 mg-10 mg-6.25 mg-5 mg; 650 mg-20 mg-12.5 mg-10 mg; varying strength
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Cold Symptoms
Acetaminophen 325 mg/ dextromethorphan 10 mg/ doxylamine 6.25 mg/ phenylephrine 5 mg per unit (tablet/capsule/liquid-filled capsule): 2 orally every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per packet: 1 packet every 4 hours
Maximum dose: 5 packets per 24 hours
Usual Pediatric Dose for Cold Symptoms
Acetaminophen 325 mg/ dextromethorphan 10 mg/ doxylamine 6.25 mg/ phenylephrine 5 mg per unit (tablet/capsule/liquid-filled capsule):
12 years and older: 2 orally every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per packet:
12 years and older: 1 packet every 4 hours
Maximum dose: 5 packets per 24 hours
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Use with caution.
Precautions
CONTRAINDICATIONS:
- Current use of any other drug containing acetaminophen.
- Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
Safety and efficacy have not been established in patients younger than 12 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Patient advice:
- Take only as directed.
- This product contains acetaminophen; severe liver damage may occur with use of more than directed, use with other acetaminophen-containing medications, or having 3 or more alcoholic drinks a day during use.
- Do not use with any other drug containing acetaminophen.
- Avoid drinking alcohol while on this drug.
- If sore throat is severe, lasts over 2 days, or is accompanied by fever, headache, rash, nausea, or vomiting, seek medical attention.
- If cough comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
- Discontinue for cough, pain, or nasal congestion that worsens or lasts over 7 days, if new symptoms arise, fever worsens or lasts over 3 days, or for redness or swelling.
More about acetaminophen / dextromethorphan / doxylamine / phenylephrine
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (3)
- Drug images
- Side effects
- During pregnancy
- Drug class: upper respiratory combinations
Patient resources
Other brands
Delsym Night Time Multi-Symptom, Alka-Seltzer Plus Severe Cold & Flu Day & Night (Night Formula), Tylenol Cold Multi-Symptom Nighttime Liquid
Related treatment guides
See also:
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Guaifenesin
Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat. Includes ...
Benadryl
Benadryl is an antihistamine and is used to treat sneezing, runny nose, itching and other ...
Diphenhydramine
Diphenhydramine is an antihistamine used to treat sneezing, runny nose, itching, hives and other ...
Benzonatate
Benzonatate is a non-narcotic cough medicine used to relieve coughing. Includes benzonatate side ...
Naproxen
Naproxen is a nonsteroidal anti-inflammatory drug used to treat pain or inflammation caused by ...
Mucinex
Mucinex (guaifenesin) is used to relieve the symptoms of cough and loosen mucus in the chest ...
Dextromethorphan
Dextromethorphan is a cough suppressant used to treat coughing. Learn about side effects ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.