Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine Dosage

Medically reviewed by Drugs.com. Last updated on May 14, 2025.

Usual Adult Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ doxylamine 6.25 mg/ phenylephrine 5 mg per unit (tablet/capsule/liquid-filled capsule): 2 orally every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per packet: 1 packet every 4 hours
Maximum dose: 5 packets per 24 hours

Usual Pediatric Dose for Cold Symptoms

Acetaminophen 325 mg/ dextromethorphan 10 mg/ doxylamine 6.25 mg/ phenylephrine 5 mg per unit (tablet/capsule/liquid-filled capsule):
12 years and older: 2 orally every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours

Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per packet:
12 years and older: 1 packet every 4 hours
Maximum dose: 5 packets per 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use with caution.

Precautions

CONTRAINDICATIONS:

• Current use of any other drug containing acetaminophen.
• Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.

Safety and efficacy have not been established in patients younger than 12 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Patient advice:

• Take only as directed.
• This product contains acetaminophen; severe liver damage may occur with use of more than directed, use with other acetaminophen-containing medications, or having 3 or more alcoholic drinks a day during use.
• Do not use with any other drug containing acetaminophen.
• Avoid drinking alcohol while on this drug.
• If sore throat is severe, lasts over 2 days, or is accompanied by fever, headache, rash, nausea, or vomiting, seek medical attention.
• If cough comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
• Discontinue for cough, pain, or nasal congestion that worsens or lasts over 7 days, if new symptoms arise, fever worsens or lasts over 3 days, or for redness or swelling.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer