Acetaminophen / Dextromethorphan / Doxylamine / Phenylephrine Dosage
Medically reviewed by Drugs.com. Last updated on Dec 3, 2018.
Applies to the following strengths: 250 mg-10 mg-6.25 mg-5 mg; 650 mg-20 mg-12.5 mg-10 mg/30 mL; 325 mg-10 mg-6.25 mg-5 mg; 325 mg-10 mg-6.25 mg-5 mg/15 mL
Usual Adult Dose for:
Usual Pediatric Dose for:
Additional dosage information:
Usual Adult Dose for Cold Symptoms
Acetaminophen 325 mg/ dextromethorphan 10 mg/ doxylamine 6.25 mg/ phenylephrine 5 mg per unit (tablet/capsule/liquid-filled capsule): 2 orally every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per 30 mL liquid: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per packet: 1 packet every 4 hours
Maximum dose: 5 packets per 24 hours
Usual Pediatric Dose for Cold Symptoms
Acetaminophen 325 mg/ dextromethorphan 10 mg/ doxylamine 6.25 mg/ phenylephrine 5 mg per unit (tablet/capsule/liquid-filled capsule):
12 years and older: 2 orally every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per 30 mL liquid:
12 years and older: 30 mL every 4 hours
Maximum dose: 4 doses per 24 hours
Acetaminophen 650 mg/ dextromethorphan 20 mg/ doxylamine 12.5 mg/ phenylephrine 10 mg per packet:
12 years and older: 1 packet every 4 hours
Maximum dose: 5 packets per 24 hours
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Use with caution.
Precautions
CONTRAINDICATIONS:
-Current use of any other drug containing acetaminophen.
-Current use of a monoamine oxidase inhibitor (MAOI) or use within 14 days of stopping a MAOI.
Safety and efficacy have not been established in patients younger than 12 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Patient advice:
-Take only as directed.
-This product contains acetaminophen; severe liver damage may occur with use of more than directed, use with other acetaminophen-containing medications, or having 3 or more alcoholic drinks a day during use.
-Do not use with any other drug containing acetaminophen.
-Avoid drinking alcohol while on this drug.
-If sore throat is severe, lasts over 2 days, or is accompanied by fever, headache, rash, nausea, or vomiting, seek medical attention.
-If cough comes back, or is accompanied or followed by fever, headache that lasts, or rash, seek medical care promptly.
-Discontinue for cough, pain, or nasal congestion that worsens or lasts over 7 days, if new symptoms arise, fever worsens or lasts over 3 days, or for redness or swelling.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about acetaminophen/dextromethorphan/doxylamine/phenylephrine
- Side Effects
- During Pregnancy
- Drug Interactions
- 1 Review
- Drug class: upper respiratory combinations
- FDA Alerts (3)
Consumer resources
- Acetaminophen, dextromethorphan, doxylamine, and phenylephrine
- Acetaminophen, Doxylamine, Dextromethorphan, and Phenylephrine Liquid
Other brands: Vicks NyQuil Severe Cold & Flu, Delsym Night Time Multi-Symptom, Tylenol Cold Multi-Symptom Nighttime Liquid
