Acetaminophen/dextromethorphan/doxylamine/phenylephrine Interactions
There are 667 drugs known to interact with acetaminophen/dextromethorphan/doxylamine/phenylephrine, along with 15 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 102 are major, 550 are moderate, and 15 are minor.
- View all 667 medications that may interact with acetaminophen/dextromethorphan/doxylamine/phenylephrine
- View acetaminophen/dextromethorphan/doxylamine/phenylephrine alcohol/food interactions (2)
- View acetaminophen/dextromethorphan/doxylamine/phenylephrine disease interactions (15)
Most frequently checked interactions
View interaction reports for acetaminophen / dextromethorphan / doxylamine / phenylephrine and the medicines listed below.
- 5-HTP (5-hydroxytryptophan)
- Acidophilus (lactobacillus acidophilus)
- Acidophilus Probiotic Blend (lactobacillus acidophilus)
- Adderall (amphetamine / dextroamphetamine)
- Advair HFA (fluticasone / salmeterol)
- Advil (ibuprofen)
- Advil Cold and Sinus (ibuprofen / pseudoephedrine)
- Advil PM (diphenhydramine / ibuprofen)
- Afluria Quadrivalent (influenza virus vaccine, inactivated)
- Alcohol (contained in alcoholic beverages) (ethanol)
- Aleve PM (diphenhydramine / naproxen)
- Alka-Seltzer Plus Maximum Strength Cold & Cough (acetaminophen / chlorpheniramine / dextromethorphan / phenylephrine)
- Alka-Seltzer Plus Maximum Strength Day Cold & Flu Liquid Gels (acetaminophen / dextromethorphan / phenylephrine)
- Allegra (fexofenadine)
- Allegra Allergy (fexofenadine)
- Allegra-D 24 Hour Allergy & Congestion (fexofenadine / pseudoephedrine)
- Amitiza (lubiprostone)
- Augmentin (amoxicillin / clavulanate)
- Augmentin XR (amoxicillin / clavulanate)
- Azo-Cranberry (cranberry)
- Backaid Max (acetaminophen / pamabrom)
- Crestor (rosuvastatin)
- Flonase (fluticasone nasal)
- Metoprolol Succinate ER (metoprolol)
- Metoprolol Tartrate (metoprolol)
- Promethazine DM (dextromethorphan / promethazine)
- Robitussin Nighttime Cough DM (dextromethorphan / doxylamine)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Zyrtec (cetirizine)
Acetaminophen/dextromethorphan/doxylamine/phenylephrine alcohol/food interactions
There are 2 alcohol/food interactions with acetaminophen / dextromethorphan / doxylamine / phenylephrine.
Acetaminophen/dextromethorphan/doxylamine/phenylephrine disease interactions
There are 15 disease interactions with acetaminophen / dextromethorphan / doxylamine / phenylephrine which include:
- alcoholism
- liver disease
- depression
- cardiovascular disease
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- BPH
- diabetes
- glaucoma
Report options
More about acetaminophen / dextromethorphan / doxylamine / phenylephrine
- acetaminophen/dextromethorphan/doxylamine/phenylephrine consumer information
- Compare alternatives
- Pricing & coupons
- Reviews (3)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Benadryl
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Diphenhydramine
Diphenhydramine is an antihistamine used to treat sneezing, runny nose, itching, hives and other ...
Benzonatate
Benzonatate is a non-narcotic cough medicine used to relieve coughing. Includes benzonatate side ...
Naproxen
Naproxen is a nonsteroidal anti-inflammatory drug used to treat pain or inflammation caused by ...
Mucinex
Mucinex (guaifenesin) is used to relieve the symptoms of cough and loosen mucus in the chest ...
Dextromethorphan
Dextromethorphan is a cough suppressant used to treat coughing. Learn about side effects ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
