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Zontivity Disease Interactions

There are 3 disease interactions with Zontivity (vorapaxar).

Major

Vorapaxar (applies to Zontivity) bleeding

Major Potential Hazard, High plausibility. Applicable conditions: Peptic Ulcer, Intracranial Hemorrhage, Bleeding Associated with Coagulation Defect

Vorapaxar increases the risk of bleeding and it is contraindicated in patients with active pathological bleeding such as intracranial hemorrhage or peptic ulcer. In other patients, consider the underlying risk of bleeding before initiating therapy. General risk factors include older age, low body weight, reduced renal or hepatic function, history of bleeding disorders, and use of certain concomitant medications. The use of warfarin and other anticoagulants should be avoided. Bleeding should be suspected in any patient who is hypotensive and has recently undergone coronary angiography, percutaneous coronary intervention (PCI), coronary artery bypass graft surgery (CABG), or any other surgical procedure.

References

  1. "Product Information. Zontivity (vorapaxar)." Merck & Co., Inc (2014):
Major

Vorapaxar (applies to Zontivity) history of stroke

Major Potential Hazard, Moderate plausibility. Applicable conditions: History - Cerebrovascular Disease, Intracranial Hemorrhage, Cerebral Thrombosis/Embolism

Vorapaxar is contraindicated in patients with a history of stroke, transient ischemic attack (TIA), or intracranial bleeding. The risk of intracranial bleeding is higher in these patients.

References

  1. "Product Information. Zontivity (vorapaxar)." Merck & Co., Inc (2014):
Major

Vorapaxar (applies to Zontivity) liver disease

Major Potential Hazard, Moderate plausibility.

No dose adjustment is required in patients with renal dysfunction or mild to moderate hepatic impairment. Vorapaxar is not recommended in patients with severe hepatic impairment due to bleeding risk.

References

  1. "Product Information. Zontivity (vorapaxar)." Merck & Co., Inc (2014):

Zontivity drug interactions

There are 208 drug interactions with Zontivity (vorapaxar).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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