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Zontivity Side Effects

Generic name: vorapaxar

Medically reviewed by Last updated on Aug 16, 2023.

Note: This document contains side effect information about vorapaxar. Some dosage forms listed on this page may not apply to the brand name Zontivity.

Applies to vorapaxar: oral tablet.


Oral route (Tablet)

Antiplatelet agents increase the risk of bleeding, including intracranial hemorrhage (ICH) and fatal bleeding. Do not use vorapaxar in patients with active pathological bleeding or a history of stroke, TIA, or ICH.

Serious side effects of Zontivity

Along with its needed effects, vorapaxar (the active ingredient contained in Zontivity) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vorapaxar:

Less common


Other side effects of Zontivity

Some side effects of vorapaxar may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to vorapaxar: oral tablet.


Bleeding, including life-threatening and fatal bleeding, is the most commonly reported adverse reaction.[Ref]


Very common (10% or more): Bleeding

Common (1% to 10%): Anemia, iron deficiency[Ref]


Common (1% to 10%): Rashes, eruptions, exanthemas[Ref]


Common (1% to 10%): Gastrointestinal bleeding[Ref]


Common (1% to 10%): Retinopathy or retinal disorder, diplopia/oculomotor disturbances[Ref]

Nervous system

Uncommon (0.1% to 1%): Intracranial bleeding[Ref]


1. Product Information. Zontivity (vorapaxar). Merck & Co., Inc. 2014.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.