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Zontivity Side Effects

Generic Name: vorapaxar

Note: This document contains side effect information about vorapaxar. Some of the dosage forms listed on this page may not apply to the brand name Zontivity.

For the Consumer

Applies to vorapaxar: oral tablet

Along with its needed effects, vorapaxar (the active ingredient contained in Zontivity) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vorapaxar:

Less common
  • Bloody or black, tarry stools
  • constipation
  • pale skin
  • severe stomach pain
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
Rare
  • Confusion
  • headache, sudden and severe
  • nausea and vomiting
  • weakness

Some side effects of vorapaxar may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • rashes
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to vorapaxar: oral tablet

General

Bleeding, including life-threatening and fatal bleeding, is the most commonly reported adverse reaction.[Ref]

Hematologic

Very common (10% or more): Bleeding
Common (1% to 10%): Anemia, iron deficiency[Ref]

Dermatologic

Common (1% to 10%): Rashes, eruptions, exanthemas[Ref]

Gastrointestinal

Common (1% to 10%): Gastrointestinal bleeding[Ref]

Ocular

Common (1% to 10%): Retinopathy or retinal disorder, diplopia/oculomotor disturbances[Ref]

Nervous system

Uncommon (0.1% to 1%): Intracranial bleeding[Ref]

References

1. "Product Information. Zontivity (vorapaxar)." Merck & Company Inc, Whitehouse Station, NJ.

Some side effects of Zontivity may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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