Vinorelbine Disease Interactions
There is 1 disease interaction with vinorelbine:
Vinorelbine (Includes vinorelbine) ↔ myelosuppression
Severe Potential Hazard, High plausibility. Applies to: Fever, Bone Marrow Depression/Low Blood Counts
The use of vinorelbine is contraindicated in patients with neutrophil counts < 1000/mm3. Vinorelbine induces dose-dependent myelosuppression, primarily neutropenia. Therapy with vinorelbine should be administered with extreme caution and dosage modification considered in patients whose bone marrow reserve may be depressed by prior chemotherapy or irradiation or whose marrow function is recovering from previous cytotoxic therapy. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression such as fever, sore throat, local infection, or bleeding. Close clinical monitoring of hematopoietic function is recommended.
- "Product Information. Navelbine (vinorelbine)." Glaxo Wellcome, Research Triangle Pk, NC.
Vinorelbine drug interactions
There are 409 drug interactions with vinorelbine
More about vinorelbine
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- Drug class: mitotic inhibitors
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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