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Vadadustat Disease Interactions

There are 5 disease interactions with vadadustat.

Major

Vadadustat (applies to vadadustat) hypertension

Major Potential Hazard, Moderate plausibility. Applicable conditions: Seizures

Vadadustat is contraindicated in patients with uncontrolled hypertension as cases of hypertensive crisis including hypertensive encephalopathy and seizures have been reported. Patients with history of seizure disorders receiving this drug should be monitored closely and should contact their health care provider for premonitory symptoms or change in seizure frequency.

Moderate

Vadadustat (applies to vadadustat) cancer

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Bladder Cancer, Breast Cancer, Lung Cancer, Prostate Cancer, Skin Cancer

An increase in hypoxia inducible factor (HIF) levels may be associated with unfavorable effects on cancer growth. The use of vadadustat has not been studied and is not recommended in patients with active malignancies.

Moderate

Vadadustat (applies to vadadustat) CVD

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cardiovascular Disease

Vadadustat increases the risk of arterial and venous thrombotic events, including major adverse cardiovascular events. Patients with cardiovascular or cerebrovascular disease are at increased risk. Avoid the use of this drug in patients with history of myocardial infarction, cerebrovascular events, or acute coronary syndrome within the 3 months prior to starting treatment.

Moderate

Vadadustat (applies to vadadustat) gastrointestinal bleeding

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Gastrointestinal Hemorrhage, Esophageal Disease, Alcoholism, Smoking

Esophageal and gastrointestinal erosions have been reported with the use of vadadustat. Some cases of serious gastrointestinal bleeding required the need for red blood cell transfusions. Patients with history of gastrointestinal erosion, peptic ulcer disease, tobacco smokers and alcohol drinkers are at increased risk.

Moderate

Vadadustat (applies to vadadustat) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Vadadustat may cause hepatotoxicity. Liver enzymes and bilirubin should be measured prior to treatment initiation and monitored during treatment. This drug is not recommended in patients with cirrhosis, or active, acute liver disease.

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Vadadustat drug interactions

There are 603 drug interactions with vadadustat.

Vadadustat alcohol/food interactions

There are 2 alcohol/food interactions with vadadustat.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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