Orenitram (treprostinil) Disease Interactions
There is 1 disease interaction with Orenitram (treprostinil):
Treprostinil (Includes Orenitram) ↔ hepatic impairment
Severe Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
The use of the extended-release tablet formulation of treprostinil is contraindicated in patients with severe hepatic impairment (Child Pugh Class C). There is a marked increase in the systemic exposure to treprostinil in hepatically impaired patients. It is recommended to start patients with mild hepatic impairment (Child Pugh Class A) at 0.125 mg BID with 0.125 mg BID dose increments every 3 to 4 days and to avoid use of treprostinil in patients with moderate hepatic impairment (Child Pugh Class B).
Orenitram (treprostinil) drug interactions
There are 689 drug interactions with Orenitram (treprostinil)
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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