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Talimogene laherparepvec Disease Interactions

There are 3 disease interactions with talimogene laherparepvec:

Major

Talimogene Laherparepvec (Includes Talimogene laherparepvec) ↔ Immunodeficiency

Severe Potential Hazard, Moderate plausibility

Applies to: Immunodeficiency

Talimogene laherparepvec is a live, attenuated herpes simplex virus. Its use is contraindicated in immunocompromised patients as they may be at risk of life-threatening disseminated herpetic infection. Do not administer talimogene laherparepvec to immunocompromised patients, including those with a history of primary or acquired immunodeficient states, leukemia, lymphoma, AIDS or other clinical manifestations of infection with human immunodeficiency viruses, and those on immunosuppressive therapy.

Moderate

Talimogene Laherparepvec (Includes Talimogene laherparepvec) ↔ Autoimmune Disorders

Moderate Potential Hazard, Moderate plausibility

Applies to: Autoimmune Disorder

The use of talimogene laherparepvec may result in immune-mediated events. Exercise care when using this agent in patients with underlying autoimmune disease or before continuing treatment in those patients that have developed immune-mediated events. Close monitoring is recommended.

Moderate

Talimogene Laherparepvec (Includes Talimogene laherparepvec) ↔ Multiple Myeloma

Moderate Potential Hazard, Moderate plausibility

Applies to: Multiple Myeloma

Plasmacytoma, in proximity to the injection site, has been reported after administration of talimogene laherparepvec in a patient with smoldering multiple myeloma. It is recommended to consider the risks and benefits of treatment in patients with multiple myeloma or in whom plasmacytoma develops during treatment. Close monitoring is recommended.

talimogene laherparepvec drug Interactions

There are 183 drug interactions with talimogene laherparepvec

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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