Talimogene laherparepvec Side Effects
For the Consumer
Applies to talimogene laherparepvec: injection suspension
As well as its needed effects, talimogene laherparepvec may cause unwanted side effects that require medical attention.
If any of the following side effects occur while taking talimogene laherparepvec, check with your doctor or nurse immediately:More common:
- general feeling of discomfort or illness
- joint pain
- loss of appetite
- muscle aches and pains
- pain at the injection site
- runny nose
- sore throat
- trouble sleeping
- unusual tiredness or weakness
- Break in the skin, especially associated with blue-black discoloration, swelling, or drainage of fluid
- burning or stinging of the skin
- painful cold sores or blisters on the lips, nose, eyes, or genitals
Minor Side Effects
Some talimogene laherparepvec side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common:
- Abdominal or stomach pain
- difficulty having a bowel movement (stool)
- difficulty with moving
- muscle pain or stiffness
- pain in the arms or legs
- weight loss
For Healthcare Professionals
Applies to talimogene laherparepvec: injectable suspension
-The most commonly reported (25% or more) adverse drug reactions were fatigue, chills, pyrexia, nausea, influenza-like illness, and injection site pain.
-Pyrexia, chills, and influenza-like illness can occur at any time during treatment, but were more frequent during the first 3 months.
-Most adverse reactions were mild or moderate in severity and generally resolved within 72 hours.
-Cellulitis was the most common grade 3 or higher adverse reaction.[Ref]
Very common (10% or more): Fatigue (50.3%), chills (48.6%), pyrexia (42.8%), influenza-like illness (30.5%), injection site pain (27.7%)
Common (1% to 10%): Decreased weight
Frequency not reported: Herpetic infection, injection site complications (cellulitis, systemic bacterial infection, impaired healing)[Ref]
Very common (10% or more): Nausea (35.6%), vomiting (21.2%), diarrhea (18.8%), constipation (11.6%)
Common (1% to 10%): Abdominal pain
Frequency not reported: Oral herpes[Ref]
Very common (10% or more): Headache (18.8%)
Common (1% to 10%): Dizziness[Ref]
Very common (10% or more): Myalgia (17.5%), arthralgia (17.1%), extremity pain (16.4%)[Ref]
Frequency not reported: Immune-mediated events (glomerulonephritis, vasculitis, pneumonitis, psoriasis, vitiligo)[Ref]
Frequency not reported: Plasmacytoma[Ref]
Common (1% to 10%): Oropharyngeal pain[Ref]
Common (1% to 10%): Decreased weight[Ref]
1. "Product Information. Imlygic (talimogene laherparepvec)." Amgen USA, Thousand Oaks, CA.
It is possible that some side effects of talimogene laherparepvec may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about talimogene laherparepvec
- Other brands: Imlygic
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