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Talimogene laherparepvec Side Effects

For the Consumer

Applies to talimogene laherparepvec: injection suspension

As well as its needed effects, talimogene laherparepvec may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking talimogene laherparepvec, check with your doctor or nurse immediately:

More common:
  • Chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain at the injection site
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting
Incidence not known:
  • Break in the skin, especially associated with blue-black discoloration, swelling, or drainage of fluid
  • burning or stinging of the skin
  • painful cold sores or blisters on the lips, nose, eyes, or genitals

Minor Side Effects

Some talimogene laherparepvec side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Abdominal or stomach pain
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dizziness
  • muscle pain or stiffness
  • pain in the arms or legs
  • weight loss

For Healthcare Professionals

Applies to talimogene laherparepvec: injectable suspension

General

-The most commonly reported (25% or more) adverse drug reactions were fatigue, chills, pyrexia, nausea, influenza-like illness, and injection site pain.
-Pyrexia, chills, and influenza-like illness can occur at any time during treatment, but were more frequent during the first 3 months.
-Most adverse reactions were mild or moderate in severity and generally resolved within 72 hours.
-Cellulitis was the most common grade 3 or higher adverse reaction.[Ref]

Other

Very common (10% or more): Fatigue (50.3%), chills (48.6%), pyrexia (42.8%), influenza-like illness (30.5%), injection site pain (27.7%)
Common (1% to 10%): Decreased weight
Frequency not reported: Herpetic infection, injection site complications (cellulitis, systemic bacterial infection, impaired healing)[Ref]

Gastrointestinal

Very common (10% or more): Nausea (35.6%), vomiting (21.2%), diarrhea (18.8%), constipation (11.6%)
Common (1% to 10%): Abdominal pain
Frequency not reported: Oral herpes[Ref]

Nervous system

Very common (10% or more): Headache (18.8%)
Common (1% to 10%): Dizziness[Ref]

Musculoskeletal

Very common (10% or more): Myalgia (17.5%), arthralgia (17.1%), extremity pain (16.4%)[Ref]

Immunologic

Frequency not reported: Immune-mediated events (glomerulonephritis, vasculitis, pneumonitis, psoriasis, vitiligo)[Ref]

Oncologic

Frequency not reported: Plasmacytoma[Ref]

Respiratory

Common (1% to 10%): Oropharyngeal pain[Ref]

Metabolic

Common (1% to 10%): Decreased weight[Ref]

References

1. "Product Information. Imlygic (talimogene laherparepvec)." Amgen USA, Thousand Oaks, CA.

It is possible that some side effects of talimogene laherparepvec may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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