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Suzetrigine Disease Interactions

There are 2 disease interactions with suzetrigine.

Moderate

Suzetrigine (applies to suzetrigine) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Suzetrigine should be avoided in patients with severe liver dysfunction. In patients with moderate liver dysfunction, systemic exposure of this drug and its active metabolite increases, raising the risk of adverse reactions. A lower dose is recommended in these patients. The dosage for patients with mild liver dysfunction is the same as for those with normal liver function.

References (1)
  1. (2025) "Product Information. Journavx (suzetrigine)." Vertex Pharmaceuticals
Moderate

Suzetrigine (applies to suzetrigine) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Suzetrigine has not been studied in patients with severe renal dysfunction. This drug should be avoided in these patients. The dosage for patients with mild to moderate renal dysfunction is the same as for those with normal renal function.

References (1)
  1. (2025) "Product Information. Journavx (suzetrigine)." Vertex Pharmaceuticals

Switch to consumer interaction data

Suzetrigine drug interactions

There are 437 drug interactions with suzetrigine.

Suzetrigine alcohol/food interactions

There is 1 alcohol/food interaction with suzetrigine.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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