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Sovaldi (sofosbuvir) Disease Interactions

There is 1 disease interaction with Sovaldi (sofosbuvir):


Direct acting antivirals (Includes Sovaldi) ↔ hepatitis reactivation

Severe Potential Hazard, Moderate plausibility. Applies to: Infectious Hepatitis

Sofosbuvir, alone or in combination with other hepatitis C virus (HCV) direct acting antiviral therapies has been associated with hepatitis B reactivation in HCV/HBV coinfected patients who were undergoing or had completed treatment with these agents, and who were not receiving HBV antiviral therapy. HBV reactivation has also been reported in patients receiving certain immunosuppressant or chemotherapeutic agents; the risk of HBV reactivation associated with treatment with HCV direct-acting antivirals may be increased in these patients. Therefore, screening for viral hepatitis should be performed in accordance with published guidelines before starting therapy with sofosbuvir. Monitor patients with evidence of current or prior HBV infection for clinical and laboratory signs of hepatitis flare or HBV reactivation.

Sovaldi (sofosbuvir) drug interactions

There are 32 drug interactions with Sovaldi (sofosbuvir)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.