Skip to main content

Sovaldi: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on March 28, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Sovaldi may be used to treat certain genotypes of the hepatitis C virus in adults and children over the age of three. It must be given in combination with other treatments and cannot be used alone to treat HCV. Most courses are for 12 weeks, but 24 weeks is needed to treat HCV genotype 3. Side effects are typically mild and may include headache, fatigue, itching, a lack of energy, and nausea.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Sovaldi may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with Sovaldi. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with Sovaldi include:

Sovaldi is usually given in combination with ribavirin. All the medications that interact with ribavirin will also interact with the combination of Sovaldi and ribavirin. In addition, women taking ribavirin should not become pregnant while taking ribavirin.

Sovaldi is a substrate of drug transporter P-gp and breast cancer resistance protein (BCRP) and medications that are P-gp inducers in the intestine such as rifampin or St. John's wort may decrease Sovaldi plasma concentrations, leading to a reduced therapeutic effect of Sovaldi. Avoid concomitant use.

Note that this list is not all-inclusive and includes only common medications that may interact with Sovaldi. You should refer to the prescribing information for Sovaldi for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Sovaldi only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: March 28, 2023.