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Sevelamer Disease Interactions

There are 3 disease interactions with sevelamer.

Major

Sevelamer (applies to sevelamer) gastrointestinal disease

Major Potential Hazard, Moderate plausibility. Applicable conditions: Intestinal Obstruction

Sevelamer is contraindicated in patients with bowel obstruction. Cases of bowel obstruction and perforation have been reported with the use of sevelamer. Care and appropriate measures should be taken if patients develop constipation or worsening of existing constipation while on sevelamer.

References

  1. "Product Information. Renagel (sevelamer)." Genzyme Corporation (2001):
  2. "Product Information. Renvela (sevelamer)." Genzyme Corporation (2009):
Moderate

Sevelamer (applies to sevelamer) dysphagia

Moderate Potential Hazard, Moderate plausibility.

Cases of dysphagia and esophageal tablet retention have been reported in association with use of the tablet formulation of sevelamer, some requiring hospitalization and intervention. Consider using sevelamer suspension in patients with a history of swallowing disorders.

References

  1. "Product Information. Renagel (sevelamer)." Genzyme Corporation (2001):
  2. "Product Information. Renvela (sevelamer)." Genzyme Corporation (2009):
Moderate

Sevelamer (applies to sevelamer) renal disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: peritoneal dialysis

Patients on peritoneal dialysis should be closely monitored to ensure the reliable use of appropriate aseptic technique with the prompt recognition and management of any signs and symptoms associated with peritonitis.

References

  1. "Product Information. Renagel (sevelamer)." Genzyme Corporation (2001):
  2. "Product Information. Renvela (sevelamer)." Genzyme Corporation (2009):

Sevelamer drug interactions

There are 42 drug interactions with sevelamer.

Sevelamer alcohol/food interactions

There are 2 alcohol/food interactions with sevelamer.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.