Secnidazole Disease Interactions
There are 2 disease interactions with secnidazole.
Secnidazole (applies to secnidazole) Cockayne syndrome
Major Potential Hazard, Moderate plausibility.
Secnidazole is contraindicated in patients with Cockayne syndrome. Severe irreversible hepatotoxicity/acute liver failure with fatal outcomes have been reported after start of metronidazole (another nitroimidazole drug structurally related to secnidazole) in patients with Cockayne syndrome.
- "Product Information. Solosec (secnidazole)." Lupin Pharmaceuticals Inc (2022):
Nitroimidazoles (applies to secnidazole) alcoholism
Moderate Potential Hazard, Moderate plausibility.
Nitroimidazoles (e.g., metronidazole, tinidazole, fexinidazole, secnidazole) may inhibit alcohol dehydrogenase and occasionally precipitate a disulfiram-like reaction in patients who consume alcohol while being treated. Symptoms may include abdominal cramps, nausea, vomiting, headache, flushing, rash, weakness, diarrhea, abdominal pain, dizziness, sweating, and hypotension. Patients should be instructed to avoid alcohol-containing products during nitroimidazole therapy and for at least 48 hours (fexinidazole, secnidazole) to 72 hours (metronidazole, tinidazole) after the last dose. Therapy with nitroimidazoles should be administered cautiously in patients who might be prone to acute alcohol intake. An alternative therapy may be appropriate.
- "Product Information. Flagyl (metronidazole)." Searle (2002):
- "Product Information. Tindamax (tinidazole)." Presutti Laboratories Inc (2004):
- "Product Information. Solosec (secnidazole)." Symbiomix Therapeutics (2017):
- "Product Information. Fexinidazole (fexinidazole)." sanofi-aventis (2021):
Secnidazole drug interactions
There are 101 drug interactions with secnidazole.
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- Drug class: amebicides
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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