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Rifabutin Disease Interactions

There are 3 disease interactions with rifabutin:

Major

Rifabutin (Includes Rifabutin) ↔ Tb

Severe Potential Hazard, High plausibility

Applies to: Tuberculosis -- Active

Rifabutin should not be given as monotherapy in patients with active tuberculosis (TB). The administration of rifabutin in the absence of appropriate antituberculous agents may induce organisms resistant to rifabutin and other rifamycins, including rifampin and rifapentine. Likewise, patients must not have active TB when receiving rifabutin therapy for Mycobacterium avium complex prophylaxis or other indications where rifabutin might be used alone. Patients who develop symptoms consistent with active TB during rifabutin therapy should be evaluated promptly so that an effective antituberculosis regimen may be instituted if necessary.

References

  1. "Product Information. Mycobutin (rifabutin)." Pharmacia and Upjohn, Kalamazoo, MI.
Moderate

Antibiotics (Includes Rifabutin) ↔ Colitis

Moderate Potential Hazard, Low plausibility

Applies to: Colitis/Enteritis (Noninfectious)

Pseudomembranous colitis has been reported with most antibacterial agents and may range in severity from mild to life-threatening, with an onset of up to two months following cessation of therapy. Antibiotic therapy can alter the normal flora of the colon and permit overgrowth of Clostridium difficile, whose toxin is believed to be a primary cause of antibiotic- associated colitis. The colitis is usually characterized by severe, persistent diarrhea and severe abdominal cramps, and may be associated with the passage of blood and mucus. The most common culprits are clindamycin, lincomycin, the aminopenicillins (amoxicillin, ampicillin), and the cephalosporins. Therapy with broad-spectrum antibiotics and other agents with significant antibacterial activity should be administered cautiously in patients with a history of gastrointestinal diseases, particularly colitis. There is some evidence that pseudomembranous colitis, if it occurs, may run a more severe course in these patients and that it may be associated with flares in their underlying disease activity. The offending antibiotic(s) should be discontinued if significant diarrhea occurs during therapy. Stool cultures for Clostridium difficile and stool assay for C. difficile toxin may be helpful diagnostically. A large bowel endoscopy may be considered to establish a definitive diagnosis in cases of severe diarrhea.

References

  1. Moriarty HJ, Scobie BA "Pseudomembranous colitis in a patient on rifampicin and ethambutol." N Z Med J 04/23/80 (1980): 294-5
  2. Thomas E, Mehta JB "Pseudomembranous colitis due to oxacillin therapy." South Med J 77 (1984): 532-3
  3. Harmon T, Burkhart G, Applebaum H "Perforated pseudomembranous colitis in the breast-fed infant." J Pediatr Surg 27 (1992): 744-6
View all 47 references
Moderate

Rifabutin (Includes Rifabutin) ↔ Neutropenia/Thrombocytopenia

Moderate Potential Hazard, Moderate plausibility

Applies to: Neutropenia, Thrombocytopenia

Rifabutin may occasionally cause neutropenia and rarely, thrombocytopenia. Patients with preexisting neutropenia and/or thrombocytopenia should be monitored closely during rifabutin therapy for further decreases in blood counts, and therapy discontinued if appropriate.

References

  1. "Product Information. Mycobutin (rifabutin)." Pharmacia and Upjohn, Kalamazoo, MI.
  2. Siegal FP, Eilbott D, Burger H, et al "Dose-limiting toxicity of rifabutin in AIDS-related complex: syndrome of arthralgia/arthritis." AIDS 4 (1990): 433-41

rifabutin drug Interactions

There are 423 drug interactions with rifabutin

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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