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Pemetrexed Disease Interactions

There are 3 disease interactions with pemetrexed:

Major

Pemetrexed (applies to pemetrexed) myelosuppression

Major Potential Hazard, Moderate plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts

Pemetrexed can suppress bone marrow function, as manifested by neutropenia, thrombocytopenia, and anemia. Patients with myelosuppression should be monitored carefully. A complete blood count is suggested at the beginning of each cycle and as needed. Treatment should not be initiated unless the ANC is >=1,500 cells/mm3, and platelet count is >=100,000 cells/mm3.

Moderate

Pemetrexed (applies to pemetrexed) liver dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

No formal studies have been conducted to examine pemetrexed in patients with hepatic impairment. Caution is advised.

Moderate

Pemetrexed (applies to pemetrexed) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Pemetrexed is primarily eliminated unchanged by the kidneys. No dose adjustment is needed in patients with creatinine clearance >=45 mL/min. Pemetrexed should not be administered to patients with creatinine clearance <45 mL/min as these patients have not been well studied. Renal function tests should be monitored at the beginning of each cycle and as needed.

Pemetrexed drug interactions

There are 317 drug interactions with pemetrexed

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.