Pemetrexed Disease Interactions
There are 3 disease interactions with pemetrexed:
Pemetrexed (applies to pemetrexed) myelosuppression
Major Potential Hazard, Moderate plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts
Pemetrexed can suppress bone marrow function, as manifested by neutropenia, thrombocytopenia, and anemia. Patients with myelosuppression should be monitored carefully. A complete blood count is suggested at the beginning of each cycle and as needed. Treatment should not be initiated unless the ANC is >=1,500 cells/mm3, and platelet count is >=100,000 cells/mm3.
Pemetrexed (applies to pemetrexed) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
No formal studies have been conducted to examine pemetrexed in patients with hepatic impairment. Caution is advised.
Pemetrexed (applies to pemetrexed) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Pemetrexed is primarily eliminated unchanged by the kidneys. No dose adjustment is needed in patients with creatinine clearance >=45 mL/min. Pemetrexed should not be administered to patients with creatinine clearance <45 mL/min as these patients have not been well studied. Renal function tests should be monitored at the beginning of each cycle and as needed.
Pemetrexed drug interactions
There are 317 drug interactions with pemetrexed
More about pemetrexed
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
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- 2 Reviews
- Drug class: antimetabolites
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|