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Pemetrexed Disease Interactions

There are 3 disease interactions with pemetrexed:


Pemetrexed (Includes Pemetrexed) ↔ Myelosuppression

Severe Potential Hazard, Moderate plausibility

Applies to: Bone Marrow Depression/Low Blood Counts

Pemetrexed can suppress bone marrow function, as manifested by neutropenia, thrombocytopenia, and anemia. Patients with myelosuppression should be monitored carefully. A complete blood count is suggested at the beginning of each cycle and as needed. Treatment should not be initiated unless the ANC is >=1,500 cells/mm3, and platelet count is >=100,000 cells/mm3.


Pemetrexed (Includes Pemetrexed) ↔ Liver Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

No formal studies have been conducted to examine pemetrexed in patients with hepatic impairment. Caution is advised.


Pemetrexed (Includes Pemetrexed) ↔ Renal Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

Pemetrexed is primarily eliminated unchanged by the kidneys. No dose adjustment is needed in patients with creatinine clearance >=45 mL/min. Pemetrexed should not be administered to patients with creatinine clearance <45 mL/min as these patients have not been well studied. Renal function tests should be monitored at the beginning of each cycle and as needed.

pemetrexed drug Interactions

There are 410 drug interactions with pemetrexed

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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