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Pemetrexed Disease Interactions

There are 3 disease interactions with pemetrexed:

Major

Pemetrexed (Includes Pemetrexed) ↔ Myelosuppression

Severe Potential Hazard, Moderate plausibility

Applies to: Bone Marrow Depression/Low Blood Counts

Pemetrexed can suppress bone marrow function, as manifested by neutropenia, thrombocytopenia, and anemia. Patients with myelosuppression should be monitored carefully. A complete blood count is suggested at the beginning of each cycle and as needed. Treatment should not be initiated unless the ANC is >=1,500 cells/mm3, and platelet count is >=100,000 cells/mm3.

Moderate

Pemetrexed (Includes Pemetrexed) ↔ Liver Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

No formal studies have been conducted to examine pemetrexed in patients with hepatic impairment. Caution is advised.

Moderate

Pemetrexed (Includes Pemetrexed) ↔ Renal Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

Pemetrexed is primarily eliminated unchanged by the kidneys. No dose adjustment is needed in patients with creatinine clearance >=45 mL/min. Pemetrexed should not be administered to patients with creatinine clearance <45 mL/min as these patients have not been well studied. Renal function tests should be monitored at the beginning of each cycle and as needed.

pemetrexed drug Interactions

There are 390 drug interactions with pemetrexed

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

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