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Pemetrexed Dosage

Medically reviewed by Last updated on Aug 31, 2023.

Applies to the following strengths: 500 mg; 100 mg; 25 mg/mL; 1 g; 750 mg; 10 mg/mL

Usual Adult Dose for Non-Small Cell Lung Cancer

500 mg/m2 IV on Day 1 of each 21-day cycle



Usual Adult Dose for Malignant Pleural Mesothelioma

500 mg/m2 IV on Day 1 of each 21-day cycle until disease progression or unacceptable toxicity

Use: In combination with cisplatin, for the initial treatment of patients with malignant pleural mesothelioma whose disease is unresectable or who are otherwise not candidates for curative surgery

Renal Dose Adjustments

CrCl 45 mL/min or greater: No adjustment recommended
CrCl less than 45 mL/min: Not recommended

If renal toxicity develops during therapy: This drug should be withheld until CrCl is 45 mL/min or greater.


Liver Dose Adjustments

Data not available

Dose Adjustments

CBC should be obtained on Days 1, 8, and 15 of each cycle. Initiation of the next cycle of this drug should be delayed until:

Upon recovery, the dosage of this drug in the next cycle should be modified as specified below.

Recommended Dosage Modifications for Adverse Reactions:
Myelosuppressive toxicity:

Nonhematologic toxicity:



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Premedication and Concomitant Agents to Mitigate Toxicity:

Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:



Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.