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Olaratumab Disease Interactions

There are 2 disease interactions with olaratumab.

Moderate

Olaratumab (applies to olaratumab) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Olaratumab population pharmacokinetic analysis in patients with mild to moderate hepatic impairment indicated that hepatic impairment had no clinically important effect on the pharmacokinetics of olaratumab. The pharmacokinetics of olaratumab in patients with severe hepatic impairment is unknown. Care and close monitoring should be exercised when using this agent in patients with severe hepatic impairment.

References

  1. (2016) "Product Information. Lartruvo (olaratumab)." Lilly, Eli and Company
Moderate

Olaratumab (applies to olaratumab) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Olaratumab population pharmacokinetic analysis in patients with mild to moderate renal impairment indicated that renal impairment had no clinically important effect on the pharmacokinetics of olaratumab. The pharmacokinetics of olaratumab in patients with severe renal impairment is unknown. Care and close monitoring should be exercised when using this agent in patients with severe renal impairment.

References

  1. (2016) "Product Information. Lartruvo (olaratumab)." Lilly, Eli and Company

Olaratumab drug interactions

There are 149 drug interactions with olaratumab.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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