Olaratumab Disease Interactions
There are 2 disease interactions with olaratumab.
Olaratumab (applies to olaratumab) hepatic impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Olaratumab population pharmacokinetic analysis in patients with mild to moderate hepatic impairment indicated that hepatic impairment had no clinically important effect on the pharmacokinetics of olaratumab. The pharmacokinetics of olaratumab in patients with severe hepatic impairment is unknown. Care and close monitoring should be exercised when using this agent in patients with severe hepatic impairment.
Olaratumab (applies to olaratumab) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Olaratumab population pharmacokinetic analysis in patients with mild to moderate renal impairment indicated that renal impairment had no clinically important effect on the pharmacokinetics of olaratumab. The pharmacokinetics of olaratumab in patients with severe renal impairment is unknown. Care and close monitoring should be exercised when using this agent in patients with severe renal impairment.
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Olaratumab drug interactions
There are 163 drug interactions with olaratumab.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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