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Mafenide topical Disease Interactions

There are 2 disease interactions with mafenide topical:

Moderate

Mafenide topical (applies to mafenide topical) acid/base balance

Moderate Potential Hazard, High plausibility. Applicable conditions: Pulmonary Impairment, Renal Dysfunction

Topically applied mafenide is absorbed and rapidly converted to a metabolite that is eliminated by the kidney. Mafenide and its metabolite inhibit carbonic anhydrase and can induce metabolic acidosis, particularly if drug levels are high or if the compensatory hyperventilation mechanism is impaired. Therapy with mafenide should be administered cautiously in patients with extensive second-degree or partial thickness burns and in patients with pulmonary or renal dysfunction. Acid-base balance should be monitored closely.

References

  1. "Product Information. Sulfamylon cream (mafenide topical)." Dow Hickam Pharmaceuticals Inc, Sugar Land, TX.
Moderate

Mafenide topical (applies to mafenide topical) hemolytic anemia/DIC

Moderate Potential Hazard, High plausibility. Applicable conditions: G-6-PD Deficiency

Hemolytic anemia with disseminated intravascular coagulation associated with a glucose-6 phosphate deficiency (G6PD) has occurred during therapy with mafenide topical. Therapy with mafenide topical should be applied cautiously in patients with G6PD deficiency.

References

  1. "Product Information. Sulfamylon cream (mafenide topical)." Dow Hickam Pharmaceuticals Inc, Sugar Land, TX.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.