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Mafenide Topical Dosage

Applies to the following strength(s): 85 mg/g ; 5%

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Bacterial Infection

Solution: Wet an 8-ply burn dressing with this solution and cover grafted area, keeping dressing wet by injecting solution into irrigation tubing every 4 hours as needed or by moistening dressing every 6 to 8 hours as needed

Comments:
-Discontinue treatment if allergic manifestations occur.
-Wound dressings may be left undisturbed, except for irrigations, for up to 5 days; additional soaks may be initiated until graft take is complete.
-Maceration of skin may result from wet dressings applied for intervals as short as 24 hours.
-Treatment should continue until autograft vascularization occurs and healing is progressing (usually in about 5 days); safety and efficacy have not been established for longer than 5 days for an individual grafting procedure.

Use: As adjunctive therapy to control bacterial infections when used under moist dressings over meshed autografts on excised burn wounds

Cream: Apply using a sterile glove to cleaned and debrided burn wounds once or twice a day, at a thickness of 1/16 inch; thicker application not recommended

Comments:
-The cream should be reapplied whenever it is removed (e.g., patient activity) to keep burns covered at all times.
-Dressings are not usually necessary, however, if the patient requires them, a thin layer of dressings may be used.
-Treatment should continue until healing is progressing well or until burn site is ready for grafting.

Use: As adjunctive therapy for the treatment of second- and third- degree burns

Usual Adult Dose for Burns - External

Solution: Wet an 8-ply burn dressing with this solution and cover grafted area, keeping dressing wet by injecting solution into irrigation tubing every 4 hours as needed or by moistening dressing every 6 to 8 hours as needed

Comments:
-Discontinue treatment if allergic manifestations occur.
-Wound dressings may be left undisturbed, except for irrigations, for up to 5 days; additional soaks may be initiated until graft take is complete.
-Maceration of skin may result from wet dressings applied for intervals as short as 24 hours.
-Treatment should continue until autograft vascularization occurs and healing is progressing (usually in about 5 days); safety and efficacy have not been established for longer than 5 days for an individual grafting procedure.

Use: As adjunctive therapy to control bacterial infections when used under moist dressings over meshed autografts on excised burn wounds

Cream: Apply using a sterile glove to cleaned and debrided burn wounds once or twice a day, at a thickness of 1/16 inch; thicker application not recommended

Comments:
-The cream should be reapplied whenever it is removed (e.g., patient activity) to keep burns covered at all times.
-Dressings are not usually necessary, however, if the patient requires them, a thin layer of dressings may be used.
-Treatment should continue until healing is progressing well or until burn site is ready for grafting.

Use: As adjunctive therapy for the treatment of second- and third- degree burns

Usual Pediatric Dose for Bacterial Infection

Solution:
3 months or older: Wet an 8-ply burn dressing with this solution and cover grafted area, keeping dressing wet by injecting solution into irrigation tubing every 4 hours as needed or by moistening dressing every 6 to 8 hours as needed

Comments:
-Discontinue treatment if allergic manifestations occur.
-Wound dressings may be left undisturbed, except for irrigations, for up to 5 days; additional soaks may be initiated until graft take is complete.
-Maceration of skin may result from wet dressings applied for intervals as short as 24 hours.
-Treatment should continue until autograft vascularization occurs and healing is progressing (usually in about 5 days); safety and efficacy have not been established for longer than 5 days for an individual grafting procedure.

Use: As adjunctive therapy to control bacterial infections when used under moist dressings over meshed autografts on excised burn wounds

Cream: Apply using a sterile glove to cleaned and debrided burn wounds once or twice a day, at a thickness of 1/16 inch; thicker application not recommended

Comments:
-The cream should be reapplied whenever it is removed (e.g., patient activity) to keep burns covered at all times.
-Dressings are not usually necessary, however, if the patient requires them, a thin layer of dressings may be used.
-Treatment should continue until healing is progressing well or until burn site is ready for grafting.

Use: As adjunctive therapy for the treatment of second- and third- degree burns

Usual Pediatric Dose for Burns - External

Solution:
3 months or older: Wet an 8-ply burn dressing with this solution and cover grafted area, keeping dressing wet by injecting solution into irrigation tubing every 4 hours as needed or by moistening dressing every 6 to 8 hours as needed

Comments:
-Discontinue treatment if allergic manifestations occur.
-Wound dressings may be left undisturbed, except for irrigations, for up to 5 days; additional soaks may be initiated until graft take is complete.
-Maceration of skin may result from wet dressings applied for intervals as short as 24 hours.
-Treatment should continue until autograft vascularization occurs and healing is progressing (usually in about 5 days); safety and efficacy have not been established for longer than 5 days for an individual grafting procedure.

Use: As adjunctive therapy to control bacterial infections when used under moist dressings over meshed autografts on excised burn wounds

Cream: Apply using a sterile glove to cleaned and debrided burn wounds once or twice a day, at a thickness of 1/16 inch; thicker application not recommended

Comments:
-The cream should be reapplied whenever it is removed (e.g., patient activity) to keep burns covered at all times.
-Dressings are not usually necessary, however, if the patient requires them, a thin layer of dressings may be used.
-Treatment should continue until healing is progressing well or until burn site is ready for grafting.

Use: As adjunctive therapy for the treatment of second- and third- degree burns

Renal Dose Adjustments

Acute renal failure: Use with caution.

Liver Dose Adjustments

Data not available

Dose Adjustments

If acidosis occurs and becomes difficult to control, especially in those with pulmonary dysfunction, discontinue therapy for 24 to 48 hours while continuing fluid therapy.

Precautions

Solution:
Safety and efficacy have not been established in patients younger than 3 months.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Solution: Following reconstitution, filter through a 0.22-micron filter prior to use.

Storage requirements:
-Cream: Dispense in a tight, light resistant container; avoid exposure to excessive heat (above 104F or 40C)
-Packets: Store in a cool, dry place.
-Reconstituted solution: Use within 48 hours of preparation.

Reconstitution/preparation techniques:
-Solution: Empty entire contents of the premeasured 50 g packet into a suitable container containing 1000 mL of sterile water for irrigation or 0.9% sodium chloride irrigation; mix until completely dissolved.

Monitoring:
-Dermatologic: Monitor sites for bacterial growth.

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