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Mafenide topical

Generic name: mafenide topical [ MAF-en-ide ]
Brand name: Sulfamylon
Dosage forms: topical cream (85 mg/g), topical powder for reconstitution (5%)
Drug class: Topical antibiotics

Medically reviewed by Drugs.com on Sep 9, 2024. Written by Cerner Multum.

What is mafenide?

Mafenide is an antibiotic that fights bacteria in the body.

Mafenide topical (for the skin) is used to prevent infection in severe burn wounds.

Mafenide may also be used for purposes not listed in this medication guide.

Mafenide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

Common side effects of mafenide topical may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use mafenide topical if you are allergic to mafenide.

To make sure mafenide topical is safe for you, tell your doctor if you have:

FDA pregnancy category C. It is not known whether mafenide topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether mafenide topical passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is mafenide used?

Your doctor will determine the correct amount and type of mafenide to use. You will receive this medication in a hospital or burn unit setting.

Mafenide cream is usually applied to the burn wound once or twice a day. The wound should be kept covered with this medicine at all times during treatment.

Mafenide powder is usually mixed together with a saline solution and applied over a gauze dressing using a syringe or irrigation tube. Mafenide is usually applied several times per day in order to keep the bandaging wet.

What happens if I miss a dose?

Because you will receive mafenide topical in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since mafenide topical is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while being treated with mafenide?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect mafenide?

It is not likely that other drugs you take orally or inject will have an effect on topically applied mafenide. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

lidocaine topical, vancomycin, gentamicin, tobramycin, Silvadene, albumin human

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.