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Mafenide topical Side Effects

Medically reviewed by Drugs.com. Last updated on Jun 13, 2023.

Applies to mafenide topical: topical cream, topical powder for solution.

Serious side effects of Mafenide topical

Along with its needed effects, mafenide topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mafenide topical:

Less common

Rare

Incidence unknown

Other side effects of Mafenide topical

Some side effects of mafenide topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence unknown

For Healthcare Professionals

Applies to mafenide topical: compounding powder, topical cream, topical powder for reconstitution.

General

In the clinical setting of severe burns, it is difficult to distinguish between an adverse reaction to this drug and burn sequelae. In a clinical study in pediatric patients with acute burns requiring autografts who received the topical solution in addition to double antibiotic solution (DAB) wound therapy (neomycin sulfate 40 mg and polymyxin B 200,000 units/L), the incidence of rash (4.6%) and itching (2.8%) in the group who received this drug was not different from that experienced with DAB dressings alone (5.7% and 1.3%, respectively).[Ref]

Local

Frequency not reported: Pain, burning sensation, rash, pruritus, excoriation, bleeding[Ref]

Dermatologic

Frequency not reported: Erythema, skin maceration, hives, blisters[Ref]

Respiratory

Frequency not reported: Tachypnea, hyperventilation, partial pressure of carbon dioxide decreased[Ref]

Metabolic

Frequency not reported: Metabolic acidosis, serum chloride increased[Ref]

Hematologic

Frequency not reported: Eosinophilia, bone marrow depression, fatal hemolytic anemia, disseminated intravascular coagulation[Ref]

Other

Frequency not reported: Face edema, swelling, porphyria[Ref]

References

1. (2022) "Product Information. Sulfamylon (mafenide topical)." Dow Hickam Pharmaceuticals Inc

2. (2003) "Product Information. Sulfamylon (mafenide topical)." Bertek Pharmaceuticals Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.