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Istradefylline Disease Interactions

There are 4 disease interactions with istradefylline.

Major

Istradefylline (applies to istradefylline) severe hepatic impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Istradefylline has not been studied in patients with severe hepatic impairment (Child-Pugh Class C), and its use should be avoided in these patients. In patients with moderate hepatic impairment (Child-Pugh B), the steady-state exposures were predicted to be 3.3-fold higher. Therefore, the maximum recommended dosage of istradefylline in patients with moderate hepatic impairment (Child-Pugh B) is 20 mg once daily. Patients should be closely monitored for adverse events when receiving treatment. No dose adjustment is needed in patients with mild hepatic impairment.

References

  1. (2019) "Product Information. Nourianz (istradefylline)." Kyowa Kirin, Inc
Moderate

Istradefylline (applies to istradefylline) end stage renal disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Istradefylline has not been evaluated in patients with end-stage renal disease (ESRD) (CrCl <15 mL/min) or ESRD requiring hemodialysis. Caution is advised if prescribed in these patients. No dosage adjustment is needed in patients with mild, moderate or severe renal impairment.

References

  1. (2019) "Product Information. Nourianz (istradefylline)." Kyowa Kirin, Inc
Moderate

Istradefylline (applies to istradefylline) psychotic disorders

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Psychosis

Because of the potential risk of exacerbating psychosis, patients with a major psychotic disorder should not be treated with istradefylline. Consider dosage reduction or discontinuation if a patient develops hallucinations or psychotic behaviors while taking this drug.

References

  1. (2019) "Product Information. Nourianz (istradefylline)." Kyowa Kirin, Inc
Moderate

Istradefylline (applies to istradefylline) smoking

Moderate Potential Hazard, Moderate plausibility.

Tobacco smoking decreased systemic exposure to istradefylline by 38% to 54%, which may decrease efficacy. Therefore, the recommended dosage in patients who smoke 20 or more cigarettes per day (or the equivalent amount of another tobacco product) should be increased to 40 mg once daily.

References

  1. (2019) "Product Information. Nourianz (istradefylline)." Kyowa Kirin, Inc

Istradefylline drug interactions

There are 171 drug interactions with istradefylline.

Istradefylline alcohol/food interactions

There is 1 alcohol/food interaction with istradefylline.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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