Skip to Content

Nourianz (istradefylline) Disease Interactions

There are 4 disease interactions with Nourianz (istradefylline):

Major

Istradefylline (Includes Nourianz) ↔ severe hepatic impairment

Major Potential Hazard, Moderate plausibility. Applies to: Liver Disease

Istradefylline has not been studied in patients with severe hepatic impairment (Child-Pugh Class C), and its use should be avoided in these patients. In patients with moderate hepatic impairment (Child-Pugh B), the steady-state exposures were predicted to be 3.3-fold higher. Therefore, the maximum recommended dosage of istradefylline in patients with moderate hepatic impairment (Child-Pugh B) is 20 mg once daily. Patients should be closely monitored for adverse events when receiving treatment. No dose adjustment is needed in patients with mild hepatic impairment.

Moderate

Istradefylline (Includes Nourianz) ↔ end stage renal disease

Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction

Istradefylline has not been evaluated in patients with end-stage renal disease (ESRD) (CrCl <15 mL/min) or ESRD requiring hemodialysis. Caution is advised if prescribed in these patients. No dosage adjustment is needed in patients with mild, moderate or severe renal impairment.

Moderate

Istradefylline (Includes Nourianz) ↔ psychotic disorders

Moderate Potential Hazard, Moderate plausibility. Applies to: Psychosis

Because of the potential risk of exacerbating psychosis, patients with a major psychotic disorder should not be treated with istradefylline. Consider dosage reduction or discontinuation if a patient develops hallucinations or psychotic behaviors while taking this drug.

Moderate

Istradefylline (Includes Nourianz) ↔ smoking

Moderate Potential Hazard, Moderate plausibility. Applies to: Smoking

Tobacco smoking decreased systemic exposure to istradefylline by 38% to 54%, which may decrease efficacy. Therefore, the recommended dosage in patients who smoke 20 or more cigarettes per day (or the equivalent amount of another tobacco product) should be increased to 40 mg once daily.

Nourianz (istradefylline) drug interactions

There are 145 drug interactions with Nourianz (istradefylline)

Nourianz (istradefylline) alcohol/food interactions

There is 1 alcohol/food interaction with Nourianz (istradefylline)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.