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Dexferrum (iron dextran) Disease Interactions

There are 5 disease interactions with Dexferrum (iron dextran):

Major

Ferrous Salts (Includes Dexferrum) ↔ Hemoglobin Abnormalities

Severe Potential Hazard, High plausibility

Applies to: Blood Transfusion, Hemoglobinopathy

There is no excretory mechanism for iron. Iron will correct only hemoglobin abnormalities due to iron deficiency and should not be used to treat conditions such as thalassemia, hemosiderosis, hemochromatosis, normocytic anemia (unless iron deficiency exists), or in patients receiving blood transfusions. Clinical monitoring of erythropoietic function and ferritin levels is recommended.

References

  1. "Product Information. INFeD (iron dextran)." Schein Pharmaceuticals Inc, Florham Park, NJ.
Major

Iron Dextran (Includes Dexferrum) ↔ Hepatic Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Liver Disease

Iron is transported in plasma complexed to transferrin, a beta1-glycoprotein synthesized by the liver. Iron is cleared from the plasma by the reticuloendothelial system (including liver) and excess stored as ferritin within the reticuloendothelial system and hepatocytes. Therapy with iron dextran should be administered with extreme caution in patients with severe hepatic dysfunction.

References

  1. "Product Information. INFeD (iron dextran)." Schein Pharmaceuticals Inc, Florham Park, NJ.
Major

Iron Dextran (Includes Dexferrum) ↔ Nervous System Dysfunction

Severe Potential Hazard, Moderate plausibility

Applies to: Neurologic Disorder, Seizures

Iron dextran has induced neurologic toxicity such as seizures, paresthesia, weakness, disorientation, and unconsciousness. Therapy with iron dextran should be administered cautiously in patients with or predisposed to neurologic dysfunction.

References

  1. "Product Information. INFeD (iron dextran)." Schein Pharmaceuticals Inc, Florham Park, NJ.
  2. Shimada A "Adverse reactions to total-dose infusion of iron dextran." Clin Pharm 1 (1982): 248-9
  3. Kumpf VJ, Holland EG "Parenteral iron dextran therapy." DICP 24 (1990): 162-6
Moderate

Iron Dextran (Includes Dexferrum) ↔ Cardiovascular Dysfunction

Moderate Potential Hazard, Moderate plausibility

Applies to: Cardiovascular Disease

Cardiac toxicity such as chest pain and tightness, shock, hypertension, tachycardia and arrhythmia have occurred during iron dextran therapy. Hypotension and flushing have been reported and are thought to be infusion- rate related. Adverse reactions experienced following therapy with iron dextran may exacerbate cardiovascular complications in patients with preexisting cardiovascular disease, caution is advised.

References

  1. "Product Information. INFeD (iron dextran)." Schein Pharmaceuticals Inc, Florham Park, NJ.
  2. Shimada A "Adverse reactions to total-dose infusion of iron dextran." Clin Pharm 1 (1982): 248-9
Moderate

Iron Dextran (Includes Dexferrum) ↔ Rheumatoid Arthritis

Minor Potential Hazard, Moderate plausibility

Applies to: Rheumatoid Arthritis

Patients with rheumatoid arthritis may have an acute exacerbation of joint pain and swelling following the administration of iron dextran.

Dexferrum (iron dextran) drug Interactions

There are 50 drug interactions with Dexferrum (iron dextran)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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