Ibutilide Disease Interactions
There are 3 disease interactions with ibutilide.
Antiarrhythmics (applies to ibutilide) cardiovascular dysfunction
Major Potential Hazard, High plausibility. Applicable conditions: Congestive Heart Failure, Hypotension
Antiarrhythmic agents can induce severe hypotension (particularly with IV administration) or induce or worsen congestive heart failure (CHF). Patients with primary cardiomyopathy or inadequately compensated CHF are at increased risk. Antiarrhythmic agents should be administered cautiously and dosage and/or frequency of administration modified in patients with hypotension or adequately compensated CHF. Alternative therapy should be considered unless these conditions are secondary to cardiac arrhythmia.
Antiarrhythmics (applies to ibutilide) electrolyte imbalance
Moderate Potential Hazard, High plausibility. Applicable conditions: Hyperkalemia, Hypokalemia, Magnesium Imbalance
Electrolyte imbalance can alter the therapeutic effectiveness of antiarrhythmic agents. Hypokalemia and hypomagnesemia can reduce the effectiveness of antiarrhythmic agents. In some cases, these disorders can exaggerate the degree of QTc prolongation and increase the potential for torsade de pointes. Hyperkalemia can potentiate the toxic effects of antiarrhythmic agents. Electrolyte imbalance should be corrected prior to initiating antiarrhythmic therapy. Clinical monitoring of cardiac function and electrolyte concentrations is recommended.
Ibutilide (applies to ibutilide) hepatic/renal
Moderate Potential Hazard, High plausibility. Applicable conditions: Liver Disease
The safety, effectiveness, and pharmacokinetics of ibutilide fumarate have not been established in patients with hepatic or renal dysfunction. It is unlikely that dosing adjustments would be necessary in these patients. Nonetheless, it should be administered cautiously in patients with abnormal liver or renal function, and monitoring is advised.
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Ibutilide drug interactions
There are 273 drug interactions with ibutilide.
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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