Flolan Disease Interactions
There are 2 disease interactions with Flolan (epoprostenol).
Epoprostenol (applies to Flolan) CHF
Major Potential Hazard, High plausibility. Applicable conditions: Congestive Heart Failure
The use of epoprostenol is contraindicated in patients with heart failure due to reduced severe left ventricular systolic dysfunction. A large study involving such patients was terminated after an interim analysis revealed a higher mortality in the group receiving epoprostenol plus standard therapy than in the group receiving standard therapy alone.
Epoprostenol (applies to Flolan) bleeding
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cerebral Thrombosis/Embolism
Epoprostenol is a potent inhibitor of platelet aggregation. Therefore, expect an increased risk for hemorrhagic complications, particularly for patients with other risk factors for bleeding. Caution and close monitoring is advised.
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Flolan drug interactions
There are 299 drug interactions with Flolan (epoprostenol).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.