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Dutasteride/tamsulosin Disease Interactions

There are 5 disease interactions with dutasteride / tamsulosin.

Major

Tamsulosin (applies to dutasteride/tamsulosin) glaucoma

Major Potential Hazard, Moderate plausibility. Applicable conditions: Glaucoma/Intraocular Hypertension, Cataracts

Intraoperative Floppy Iris Syndrome (IFIS) has been observed during cataract and glaucoma surgery in some patients on or previously treated with alpha 1 blockers, including tamsulosin. The initiation of therapy with tamsulosin in patients for whom cataract or glaucoma surgery is scheduled is not recommended. The patient's ophthalmologist should be aware if the patient is receiving treatment with this drug and should be prepared for possible modifications to the surgical technique, such as the utilization of iris hooks, iris dilator rings, or viscoelastic substances.

References

  1. "Product Information. Flomax (tamsulosin)." Boehringer-Ingelheim (2001):
Moderate

5-alpha-reductase inhibitors (applies to dutasteride/tamsulosin) liver disease

Moderate Potential Hazard, Moderate plausibility.

Finasteride and dutasteride are extensively metabolized by the liver. Therapy with these drugs should be administered cautiously in patients with liver disease as exposure could be higher.

References

  1. "Product Information. Proscar (finasteride)." Merck & Company Inc (2002):
  2. "Product Information. Duagen (dutasteride)." GlaxoSmithKline Healthcare (2002):
Moderate

Alpha-1 blockers (applies to dutasteride/tamsulosin) hypotension

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Autonomic Neuropathy, Syncope, Dehydration, Diarrhea, Vomiting

Peripheral alpha 1- adrenergic receptor blocking agents (aka alpha 1- blockers) cause vasodilation and can produce marked hypotension, especially orthostatic hypotension with syncope or other postural symptoms such as dizziness, lightheadedness, and palpitations. Orthostatic effects are most common during initiation of therapy and often occur within 90 minutes after the first dose. However, they can also occur following a dosage increase or resumption of therapy after an interruption of more than a few days. Agents with alpha 1a specificity, such as tamsulosin, act primarily on the prostate but are not devoid of hypotensive effects. Therapy with peripheral alpha-1 blockers should be administered cautiously in patients with or predisposed to hypotensive or syncopal episodes. Caution is also advised in patients who are dehydrated (e.g., due to severe or prolonged diarrhea or vomiting), since they may be more sensitive to the hypotensive effect of the drugs. Therapy should be initiated with the lowest dosage possible and titrated gradually based on patient response and tolerance in accordance with the individual product package labeling. During initiation or reinstitution of therapy and following an increase in dosage, patients should be advised not to rise abruptly from a sitting or recumbent position and to avoid situations where injury could result if syncope occur. Concomitant use of alcohol, extensive periods of standing, prolonged or intense exercise, and exposure to heat can also precipitate orthostatic hypotension and should be minimized. If dizziness, lightheadedness or palpitations occur, the patient should sit or lie down, and seek medical attention if symptoms are recurrent or bothersome.

References

  1. Grunstein JA "The problem of postural hypotension." Gerontol Clin (Basel) 16 (1974): 171-4
  2. Glass AR, Ballou R "Pheochromocytoma, prazosin, and hypotension." Ann Intern Med 97 (1982): 455
  3. Melkild A "Prazosin (peripress): a long-term study." Curr Med Res Opin 9 (1984): 219-28
  4. Graham RM, Thornell IR, Gain JM, Bagnoli C, Oates HF, Stokes GS "Prazosin: the first-dose phenomenon." Br Med J 2 (1976): 1293-4
  5. "Prazosin (Minipress) for hypertension." Med Lett Drugs Ther 19 (1977): 1-2
  6. Salim SS, Mtui EP, Makene WJ "An open evaluation of the efficacy and toleration of prazosin in patients with hypertension." East Afr Med J 54 (1977): 429-33
  7. "Product Information. Cardura (doxazosin)." Pfizer U.S. Pharmaceuticals (2001):
  8. "Product Information. Hytrin (terazosin)." Abbott Pharmaceutical (2001):
  9. Troffa C, Manunta P, Dessifulgheri P, Pazzola A, Sabino G, Patteri G, Tonolo G, Pupita G, Glorioso N, Gitti M, Rappelli A "Efficacy and tolerability of doxazosin alone or in combination with chlorthalidone in essential hypertension." Curr Ther Res Clin Exp 55 (1994): 22-31
  10. Ahaneku JE, Taylor OG, Walker D, Agbedana OE, Salako LA "Blood pressure and biochemical changes during doxazosin monotherapy in nigerian hypertensive patients." Curr Ther Res Clin Exp 55 (1994): 1067-74
  11. Takata Y, Yoshizumi T, Ito Y, Hirota Y, Fujishima M "Effect of administration and withdrawal of doxazosin on ambulatory blood pressure in patients with essential hypertension." Angiology 46 (1995): 11-8
  12. Limbird LE eds., Gilman AG, Hardman JG "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: McGraw-Hill (1995):
  13. Roehrborn CG, Siegel RL "Safety and efficacy of doxazosin in benign prostatic hyperplasia: a pooled analysis of three double-blind, placebo-controlled studies." Urology 48 (1996): 406-15
  14. "Product Information. Flomax (tamsulosin)." Boehringer-Ingelheim (2001):
  15. "Product Information. Uroxatral (alfuzosin)." sanofi-aventis (2003):
  16. "Product Information. Rapaflo (silodosin)." Watson Pharmaceuticals (2008):
View all 16 references
Moderate

Tamsulosin (applies to dutasteride/tamsulosin) end-stage renal disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Patients with renal impairment do not require an adjustment in tamsulosin dosing. However, patients with end-stage renal disease (Clcr <10 mL/min) have not been studied.

References

  1. "Product Information. Flomax (tamsulosin)." Boehringer-Ingelheim (2001):
Moderate

Tamsulosin (applies to dutasteride/tamsulosin) severe liver disease

Moderate Potential Hazard, Moderate plausibility.

Patients with moderate hepatic impairment do not require any adjustment in tamsulosin dosage. Tamsulosin has not been studied in patients with severe hepatic impairment.

References

  1. "Product Information. Flomax (tamsulosin)." Boehringer-Ingelheim (2001):

Dutasteride/tamsulosin drug interactions

There are 310 drug interactions with dutasteride / tamsulosin.

Dutasteride/tamsulosin alcohol/food interactions

There are 2 alcohol/food interactions with dutasteride / tamsulosin.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.