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Daratumumab Disease Interactions

There are 2 disease interactions with daratumumab:


Daratumumab (Includes daratumumab) ↔ cytopenias

Moderate Potential Hazard, Moderate plausibility. Applies to: Neutropenia, Thrombocytopenia

The use of daratumumab may increase neutropenia and thrombocytopenia induced by background therapy. It is recommended to monitor complete blood cell counts periodically during treatment according to manufacturer's prescribing information for background therapies. Dose delay may be required to allow recovery of neutrophils and platelets and supportive care should be considered.


Daratumumab (Includes daratumumab) ↔ infusion reactions

Moderate Potential Hazard, Moderate plausibility. Applies to: Chronic Obstructive Pulmonary Disease

The use of daratumumab can cause severe infusion reactions, including bronchospasm, hypoxia, dyspnea, hypertension, laryngeal edema and pulmonary edema. Caution should be taken in patients with a history of chronic obstructive pulmonary disease as they may require additional post-infusion medications to manage respiratory complications as appropriate.

Daratumumab drug interactions

There are 111 drug interactions with daratumumab

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.