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Iodo Plain (clioquinol topical) Disease Interactions

There are 2 disease interactions with Iodo Plain (clioquinol topical):

Moderate

Clioquinol topical (applies to Iodo Plain) oculo-/neurotoxicity

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Peripheral Neuropathy, Visual Defect/Disturbance

The use of oral clioquinol (no longer marketed in the U.S.), generally at high dosages for prolonged periods, has resulted in ocular and neurologic toxicity, including optic neuritis, optic atrophy, and subacute myelo-optic neuropathy. Because the drug is systemically absorbed following topical administration to the skin, therapy with topical clioquinol should be administered cautiously in patients with peripheral neuropathy, optic neuritis, or preexisting visual defects. The use of occlusive dressings may substantially increase percutaneous absorption and should be avoided. All patients should be advised to immediately discontinue the drug and contact a physician if visual disturbances occur or are exacerbated during therapy. Clioquinol is not recommended for use in children and is contraindicated for those under 2 years of age.

References

  1. "Product Information. Vioform (clioquinol topical)." Ciba-Geigy Pharmaceuticals, East Hanover, NJ.
Moderate

Clioquinol topical (applies to Iodo Plain) thyroid dysfunction

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Hyperthyroidism, Hypothyroidism

Percutaneous absorption of clioquinol topical occurs. Protein-bound serum iodine levels may be increased during treatment with clioquinol topical and may interfere with certain thyroid function tests. Therapy with clioquinol topical should be used cautiously in patients with thyroid dysfunction.

References

  1. "Product Information. Vioform (clioquinol topical)." Ciba-Geigy Pharmaceuticals, East Hanover, NJ.

Iodo Plain (clioquinol topical) drug interactions

There is 1 drug interaction with Iodo Plain (clioquinol topical)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.