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Betaderm Disease Interactions

There are 5 disease interactions with Betaderm (betamethasone topical).

Moderate

Topical corticosteroids (applies to Betaderm) diabetes

Moderate Potential Hazard, Low plausibility. Applicable conditions: Abnormal Glucose Tolerance, Diabetes Mellitus

Corticosteroids can raise blood glucose level by antagonizing the action and suppressing the secretion of insulin, which results in inhibition of peripheral glucose uptake and increased gluconeogenesis. Therapy with topical corticosteroids rarely produces these effects but should be administered cautiously nonetheless in patients with diabetes mellitus, glucose intolerance, or a predisposition to hyperglycemia. Systemic absorption of topical corticosteroids may occur depending on the vehicle and concentration of the preparation, the size of the application area, the integrity of the skin, and the duration of administration. Use of occlusive dressings over the applied areas may also increase percutaneous absorption. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios. If possible, the use of highly potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) should be avoided in children and limited to small areas for 2 weeks in adults.

References

  1. Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
  2. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
  3. "Product Information. Lidex (fluocinonide topical)." Syntex Laboratories Inc (2022):
  4. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc (2001):
  5. "Product Information. Halog (halcinonide topical)." Bristol-Myers Squibb
  6. "Product Information. Ultravate (halobetasol topical)." Apothecon Inc (2022):
  7. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome (2001):
  8. "Product Information. Diprolene (betamethasone topical)." Schering Corporation (2001):
  9. "Product Information. Temovate (clobetasol topical)." Glaxo Wellcome
  10. "Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Company Inc (2001):
  11. "Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome (2001):
  12. "Product Information. Cyclocort (amcinonide topical)." Fujisawa (2001):
  13. "Product Information. Desowen (desonide topical)." Galderma Laboratories Inc (2001):
  14. "Product Information. Topicort (desoximetasone topical)." Hoechst Marion Roussel
  15. "Product Information. Psorcon (diflorasone topical)." Rhone Poulenc Rorer (2001):
  16. "Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc (2001):
  17. "Product Information. Elocon (mometasone topical)." Schering Corporation (2001):
  18. "Product Information. Proctocream HC (hydrocortisone-pramoxine topical)." Schwarz Pharma (2022):
  19. "Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa (2001):
  20. "Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation (2001):
  21. "Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals (2001):
  22. "Product Information. Pandel (hydrocortisone topical)." Savage Laboratories (2001):
  23. "Product Information. Cloderm (clocortolone topical)." Hermal Pharmaceutical Labs Inc (2001):
View all 23 references
Moderate

Topical corticosteroids (applies to Betaderm) diaper rash

Moderate Potential Hazard, High plausibility.

Topical corticosteroids, especially the potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol), are generally not recommended for use in the treatment of diaper rash. Topical corticosteroids may be systemically absorbed, depending on the vehicle and concentration of the preparation, the size of the application area, the duration of administration, and whether or not occlusive dressings are used. Given equivalent doses, small children are usually at the greatest risk for systemic toxicity such as adrenal suppression, Cushing's syndrome and intracranial hypertension because of their larger skin surface to body mass ratios. If topical corticosteroids are necessary to treat diaper rash, medium- to low-potency agents should preferably be used, and parents should be advised not to put tight-fitting diapers or plastic pants over the rash, since occlusion of treated area may increase percutaneous drug absorption.

References

  1. May P, Stein EJ, Ryter RJ, Hirsh FS, Michel B, Levy RP "Cushing syndrome from percutaneous absorption of triamcinolone cream." Arch Intern Med 136 (1976): 612-3
  2. Stoppoloni G, Prisco F, Santinelli R, Sicuranza G, Giordano C "Potential hazards of topical steroid therapy." Am J Dis Child 137 (1983): 1130-1
  3. Ruiz-Maldonado R, Zapata G, Lourdes T, Robles C "Cushing's syndrome after topical application of corticosteroids." Am J Dis Child 136 (1982): 274-5
  4. Reymann F, Kehlet H "Hypothalamic-pituitary-adrenocortical function. Association with topical application of betamethasone dipropionate." Arch Dermatol 115 (1979): 362-3
  5. Walsh P, Aeling JL, Huff L, Weston WL "Hypothalamus-pituitary-adrenal axis suppression by superpotent topical steroids." J Am Acad Dermatol 29 (1993): 501-3
  6. Nathan AW, Rose GL "Fatal iatrogenic Cushing's syndrome." Lancet 1 (1979): 207
  7. Macdonald A "Topical corticosteroid preparations. Hazards and side-effects." Br J Clin Pract 25 (1971): 421-5
  8. Salde L, Lassus A "Systemic side-effects of three topical steroids in diseased skin." Curr Med Res Opin 8 (1983): 475-80
  9. Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
  10. Ohman EM, Rogers S, Meenan FO, McKenna TJ "Adrenal suppression following low-dose topical clobetasol propionate [published erratum appears in J R Soc Med 1988 May;81(5):308]." J R Soc Med 80 (1987): 422-4
  11. Young CA, Williams IR, MacFarlane IA "Unrecognised Cushing's syndrome and adrenal suppression due to topical clobetasol propionate." Br J Clin Pract 45 (1991): 61-2
  12. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
  13. Novak E, Francom SF, Schlagel CA "Adrenal suppression with high-potency corticosteroid ointment formulations in normal subjects." Clin Ther 6 (1983): 59-71
  14. Gomez EC, Kaminester L, Frost P "Topical halcinonide and betamethasone valerate effects on plasma cortisol: acute and subacute usage studies." Arch Dermatol 113 (1977): 1196-202
  15. "Product Information. Lidex (fluocinonide topical)." Syntex Laboratories Inc (2022):
  16. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc (2001):
  17. "Product Information. Halog (halcinonide topical)." Bristol-Myers Squibb
  18. "Product Information. Ultravate (halobetasol topical)." Apothecon Inc (2022):
  19. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome (2001):
  20. "Product Information. Diprolene (betamethasone topical)." Schering Corporation (2001):
  21. "Product Information. Temovate (clobetasol topical)." Glaxo Wellcome
  22. Patel L, Clayton PE, Addison GM, Price DA, David TJ "Adrenal function following topical steroid treatment in children with atopic dermatitis." Br J Dermatol 132 (1995): 950-5
  23. Howland WC "Fluticasone propionate: topical or systemic effects?" Clin Exp Allergy 26 ( Suppl (1996): 18-22
  24. "Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Company Inc (2001):
  25. "Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome (2001):
  26. "Product Information. Cyclocort (amcinonide topical)." Fujisawa (2001):
  27. "Product Information. Desowen (desonide topical)." Galderma Laboratories Inc (2001):
  28. "Product Information. Topicort (desoximetasone topical)." Hoechst Marion Roussel
  29. "Product Information. Psorcon (diflorasone topical)." Rhone Poulenc Rorer (2001):
  30. "Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc (2001):
  31. "Product Information. Elocon (mometasone topical)." Schering Corporation (2001):
  32. "Product Information. Proctocream HC (hydrocortisone-pramoxine topical)." Schwarz Pharma (2022):
  33. "Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa (2001):
  34. "Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation (2001):
  35. "Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals (2001):
  36. "Product Information. Pandel (hydrocortisone topical)." Savage Laboratories (2001):
  37. "Product Information. Cloderm (clocortolone topical)." Hermal Pharmaceutical Labs Inc (2001):
View all 37 references
Moderate

Topical corticosteroids (applies to Betaderm) hyperadrenocorticism

Moderate Potential Hazard, Low plausibility. Applicable conditions: Liver Disease

The use of topical corticosteroids may precipitate or aggravate conditions of hyperadrenocorticism. Systemic absorption of these agents can produce reversible hypothalamic-pituitary-adrenal axis suppression. Systemic absorption, depends on the vehicle and concentration of the preparation, the size of the application area, the duration of administration, and whether or not occlusive dressings are used. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios. Patients with an altered skin barrier or liver failure are also at increased risk. If possible, the use of highly potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) should be avoided in children and limited to small areas for 2 weeks in adults. The development of symptoms such as menstrual irregularities, acneiform lesions, cataracts and cushingoid features during topical corticosteroid therapy may indicate excessive use.

References

  1. May P, Stein EJ, Ryter RJ, Hirsh FS, Michel B, Levy RP "Cushing syndrome from percutaneous absorption of triamcinolone cream." Arch Intern Med 136 (1976): 612-3
  2. Stoppoloni G, Prisco F, Santinelli R, Sicuranza G, Giordano C "Potential hazards of topical steroid therapy." Am J Dis Child 137 (1983): 1130-1
  3. Ruiz-Maldonado R, Zapata G, Lourdes T, Robles C "Cushing's syndrome after topical application of corticosteroids." Am J Dis Child 136 (1982): 274-5
  4. Nathan AW, Rose GL "Fatal iatrogenic Cushing's syndrome." Lancet 1 (1979): 207
  5. Macdonald A "Topical corticosteroid preparations. Hazards and side-effects." Br J Clin Pract 25 (1971): 421-5
  6. Salde L, Lassus A "Systemic side-effects of three topical steroids in diseased skin." Curr Med Res Opin 8 (1983): 475-80
  7. Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
  8. Young CA, Williams IR, MacFarlane IA "Unrecognised Cushing's syndrome and adrenal suppression due to topical clobetasol propionate." Br J Clin Pract 45 (1991): 61-2
  9. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
  10. Watson WA, Kalb RE, Siskin SB, Freer JP, Krochmal L "The safety of halobetasol 0.05% ointment in the treatment of psoriasis [published erratum appears in Pharmacotherapy 1991;11(3):preceding Table of Contents]." Pharmacotherapy 10 (1990): 107-11
  11. "Product Information. Lidex (fluocinonide topical)." Syntex Laboratories Inc (2022):
  12. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc (2001):
  13. "Product Information. Halog (halcinonide topical)." Bristol-Myers Squibb
  14. "Product Information. Ultravate (halobetasol topical)." Apothecon Inc (2022):
  15. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome (2001):
  16. "Product Information. Diprolene (betamethasone topical)." Schering Corporation (2001):
  17. "Product Information. Temovate (clobetasol topical)." Glaxo Wellcome
  18. Howland WC "Fluticasone propionate: topical or systemic effects?" Clin Exp Allergy 26 ( Suppl (1996): 18-22
  19. "Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Company Inc (2001):
  20. "Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome (2001):
  21. "Product Information. Cyclocort (amcinonide topical)." Fujisawa (2001):
  22. "Product Information. Desowen (desonide topical)." Galderma Laboratories Inc (2001):
  23. "Product Information. Topicort (desoximetasone topical)." Hoechst Marion Roussel
  24. "Product Information. Psorcon (diflorasone topical)." Rhone Poulenc Rorer (2001):
  25. "Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc (2001):
  26. "Product Information. Elocon (mometasone topical)." Schering Corporation (2001):
  27. "Product Information. Proctocream HC (hydrocortisone-pramoxine topical)." Schwarz Pharma (2022):
  28. "Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa (2001):
  29. "Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation (2001):
  30. "Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals (2001):
  31. "Product Information. Pandel (hydrocortisone topical)." Savage Laboratories (2001):
  32. "Product Information. Cloderm (clocortolone topical)." Hermal Pharmaceutical Labs Inc (2001):
View all 32 references
Moderate

Topical corticosteroids (applies to Betaderm) infections

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral, Tuberculosis -- Latent

Topical corticosteroids may be systemically absorbed, depending on the vehicle and concentration of the preparation, the size of the application area, the duration of administration, and whether or not occlusive dressings are used. Clinically significant local as well as systemic immunosuppressant and anti-inflammatory effects may occur, which can cause or exacerbate an infection. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios. Therapy with topical corticosteroids should be administered cautiously in patients with latent or active infections, particularly if a potent agent is used on a large area for prolonged periods or if occlusive dressings are used. Effective antimicrobial therapy or other appropriate treatment should be instituted to treat the infection. If possible, the use of highly potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) should be avoided in children and limited to small areas for 2 weeks in adults. Occlusive dressings should not be used in patients with skin infection.

References

  1. Macdonald A "Topical corticosteroid preparations. Hazards and side-effects." Br J Clin Pract 25 (1971): 421-5
  2. Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
  3. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
  4. "Product Information. Lidex (fluocinonide topical)." Syntex Laboratories Inc (2022):
  5. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc (2001):
  6. "Product Information. Halog (halcinonide topical)." Bristol-Myers Squibb
  7. "Product Information. Ultravate (halobetasol topical)." Apothecon Inc (2022):
  8. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome (2001):
  9. "Product Information. Diprolene (betamethasone topical)." Schering Corporation (2001):
  10. "Product Information. Temovate (clobetasol topical)." Glaxo Wellcome
  11. "Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Company Inc (2001):
  12. "Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome (2001):
  13. "Product Information. Cyclocort (amcinonide topical)." Fujisawa (2001):
  14. "Product Information. Desowen (desonide topical)." Galderma Laboratories Inc (2001):
  15. "Product Information. Topicort (desoximetasone topical)." Hoechst Marion Roussel
  16. "Product Information. Psorcon (diflorasone topical)." Rhone Poulenc Rorer (2001):
  17. "Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc (2001):
  18. "Product Information. Elocon (mometasone topical)." Schering Corporation (2001):
  19. "Product Information. Proctocream HC (hydrocortisone-pramoxine topical)." Schwarz Pharma (2022):
  20. "Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa (2001):
  21. "Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation (2001):
  22. "Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals (2001):
  23. "Product Information. Pandel (hydrocortisone topical)." Savage Laboratories (2001):
  24. "Product Information. Cloderm (clocortolone topical)." Hermal Pharmaceutical Labs Inc (2001):
View all 24 references
Moderate

Topical corticosteroids (applies to Betaderm) ocular toxicities

Moderate Potential Hazard, Low plausibility. Applicable conditions: Cataracts, Glaucoma/Intraocular Hypertension

Prolonged use of corticosteroids may cause posterior subcapsular cataracts and elevated intraocular pressure, the latter of which may lead to glaucoma and/or damage to the optic nerves. Therapy with topical corticosteroids rarely produces these effects but should be administered cautiously nonetheless in patients with a history of cataracts, glaucoma, or increased intraocular pressure, especially when potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) are used in the periorbital area. Topical corticosteroids may be systemically absorbed, depending on the vehicle and concentration of the preparation, the size of the application area, the duration of administration, and whether or not occlusive dressings are used. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios.

References

  1. Kitazawa Y "Increased intraocular pressure induced by corticosteroids." Am J Ophthalmol 82 (1976): 492-5
  2. Eisenlohr JE "Glaucoma following the prolonged use of topical steroid medication to the eyelids." J Am Acad Dermatol 8 (1983): 878-81
  3. Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
  4. Aggarwal RK, Potamitis T, Chong NH, Guarro M, Shah P, Kheterpal S "Extensive visual loss with topical facial steroids." Eye 7(Pt 5) (1993): 664-6
  5. Cubey RB "Glaucoma following the application of corticosteroid to the skin of the eyelids." Br J Dermatol 95 (1976): 207-8
  6. Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
  7. "Product Information. Lidex (fluocinonide topical)." Syntex Laboratories Inc (2022):
  8. "Product Information. Synalar (fluocinolone topical)." Syntex Laboratories Inc (2001):
  9. "Product Information. Halog (halcinonide topical)." Bristol-Myers Squibb
  10. "Product Information. Ultravate (halobetasol topical)." Apothecon Inc (2022):
  11. "Product Information. Cutivate (fluticasone)." Glaxo Wellcome (2001):
  12. "Product Information. Diprolene (betamethasone topical)." Schering Corporation (2001):
  13. "Product Information. Temovate (clobetasol topical)." Glaxo Wellcome
  14. "Product Information. Decadron Phosphate, Topical (dexamethasone topical)." Merck & Company Inc (2001):
  15. "Product Information. Aclovate (alclometasone topical)." Glaxo Wellcome (2001):
  16. "Product Information. Cyclocort (amcinonide topical)." Fujisawa (2001):
  17. "Product Information. Desowen (desonide topical)." Galderma Laboratories Inc (2001):
  18. "Product Information. Topicort (desoximetasone topical)." Hoechst Marion Roussel
  19. "Product Information. Psorcon (diflorasone topical)." Rhone Poulenc Rorer (2001):
  20. "Product Information. Cordran (flurandrenolide topical)." Oclassen Pharmaceuticals Inc (2001):
  21. "Product Information. Elocon (mometasone topical)." Schering Corporation (2001):
  22. "Product Information. Proctocream HC (hydrocortisone-pramoxine topical)." Schwarz Pharma (2022):
  23. "Product Information. Aristocort Topical (triamcinolone topical)." Fujisawa (2001):
  24. "Product Information. Kenalog (triamcinolone topical)." Westwood Squibb Pharmaceutical Corporation (2001):
  25. "Product Information. Dermatop (prednicarbate topical)." Janssen Pharmaceuticals (2001):
  26. "Product Information. Pandel (hydrocortisone topical)." Savage Laboratories (2001):
  27. "Product Information. Cloderm (clocortolone topical)." Hermal Pharmaceutical Labs Inc (2001):
View all 27 references

Betaderm drug interactions

There are 45 drug interactions with Betaderm (betamethasone topical).


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.