Benzalkonium chloride/benzocaine/menthol topical Disease Interactions
There is 1 disease interaction with benzalkonium chloride / benzocaine / menthol topical.
Benzocaine (applies to benzalkonium chloride/benzocaine/menthol topical) methemoglobinemia
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency
Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.
References (2)
- (2001) "Product Information. Americaine (benzocaine topical)." Novartis Consumer Health
- (2001) "Product Information. Americaine Otic (benzocaine otic)." Medeva Pharmaceuticals
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Benzalkonium chloride/benzocaine/menthol topical drug interactions
There are 58 drug interactions with benzalkonium chloride / benzocaine / menthol topical.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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